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A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome.

Wang X, Ge L, Cui Y, Lang C, Hao C - Int J Fertil Steril (2014)

Bottom Line: The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels.The results of the hCG test indicated that T/E2 could recover to a normal level.The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining.

View Article: PubMed Central - PubMed

Affiliation: Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China.

ABSTRACT
FSH-secreting pituitary adenomas can affect sexual and reproductive function. In this article, we have reported the case of a 32-year-old male with secondary infertility. The patient had sexual and reproductive disturbances. The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels. Based on previous hormonal results, the patient received pituitary stimulation and human chorionic gonadotropin (hCG) tests. Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed low response during the pituitary stimulation test. The results of the hCG test indicated that T/E2 could recover to a normal level. In addition, this patient was diagnosed with pituitary macroadenoma, which was supported by the pituitary MRI. The man's sexual and reproductive functions recovered following surgery. The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining. The purpose of this report was to review the relative literature and discuss the influence of FSH-secreting pituitary adenomas on hormones through the hypothalamus-pituitary-testis axis.

No MeSH data available.


Related in: MedlinePlus

The histologic findings were compatible with pituitaryadenoma (A. HE×100). The focus of the tumor cells werepositive for β-FSH immunostaining (B. ×400).
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Figure 3: The histologic findings were compatible with pituitaryadenoma (A. HE×100). The focus of the tumor cells werepositive for β-FSH immunostaining (B. ×400).


A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome.

Wang X, Ge L, Cui Y, Lang C, Hao C - Int J Fertil Steril (2014)

The histologic findings were compatible with pituitaryadenoma (A. HE×100). The focus of the tumor cells werepositive for β-FSH immunostaining (B. ×400).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3973166&req=5

Figure 3: The histologic findings were compatible with pituitaryadenoma (A. HE×100). The focus of the tumor cells werepositive for β-FSH immunostaining (B. ×400).
Bottom Line: The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels.The results of the hCG test indicated that T/E2 could recover to a normal level.The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining.

View Article: PubMed Central - PubMed

Affiliation: Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China.

ABSTRACT
FSH-secreting pituitary adenomas can affect sexual and reproductive function. In this article, we have reported the case of a 32-year-old male with secondary infertility. The patient had sexual and reproductive disturbances. The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels. Based on previous hormonal results, the patient received pituitary stimulation and human chorionic gonadotropin (hCG) tests. Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed low response during the pituitary stimulation test. The results of the hCG test indicated that T/E2 could recover to a normal level. In addition, this patient was diagnosed with pituitary macroadenoma, which was supported by the pituitary MRI. The man's sexual and reproductive functions recovered following surgery. The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining. The purpose of this report was to review the relative literature and discuss the influence of FSH-secreting pituitary adenomas on hormones through the hypothalamus-pituitary-testis axis.

No MeSH data available.


Related in: MedlinePlus