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A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome.

Wang X, Ge L, Cui Y, Lang C, Hao C - Int J Fertil Steril (2014)

Bottom Line: The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels.The results of the hCG test indicated that T/E2 could recover to a normal level.The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining.

View Article: PubMed Central - PubMed

Affiliation: Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China.

ABSTRACT
FSH-secreting pituitary adenomas can affect sexual and reproductive function. In this article, we have reported the case of a 32-year-old male with secondary infertility. The patient had sexual and reproductive disturbances. The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels. Based on previous hormonal results, the patient received pituitary stimulation and human chorionic gonadotropin (hCG) tests. Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed low response during the pituitary stimulation test. The results of the hCG test indicated that T/E2 could recover to a normal level. In addition, this patient was diagnosed with pituitary macroadenoma, which was supported by the pituitary MRI. The man's sexual and reproductive functions recovered following surgery. The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining. The purpose of this report was to review the relative literature and discuss the influence of FSH-secreting pituitary adenomas on hormones through the hypothalamus-pituitary-testis axis.

No MeSH data available.


Related in: MedlinePlus

Cornal (A) and sagittal (B) MRI sections revealed ahuge well-enhanced mass in the sella turcica.
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Figure 2: Cornal (A) and sagittal (B) MRI sections revealed ahuge well-enhanced mass in the sella turcica.

Mentions: The results of the GnRH stimulation test manifesteda low response of the serum LH and FSH levels afterthe administration of 0.1 mg GnRH (Fig 1). The karyotype of this patient was 46 XY. The result of a plainMRI scan revealed that the sella turcica was clearly enlarged, which contained an elliptic lump (2.5 ×2.0 ×1.8cm) and appeared as slightly longer T1 and T2 signals.In front of the lump, several cycloid cysts appeared aslong T1 and T2 signals. The basilar part of the sellaturcica clearly sagged and the pituitary stalk was notclearly visible because of space occupation in the sphenoid sinus and sellar area. The optic chiasma was obviously oppressed and its location was moved upward.In addition, the bilateral carotid arteries were encaseddue to oppression of the surrounding tissues. Based onthese signs, a pituitary adenoma was confirmed (Fig 2)


A FSH-Secreting Pituitary Macroadenoma Causing A Testosterone Deficiency Syndrome.

Wang X, Ge L, Cui Y, Lang C, Hao C - Int J Fertil Steril (2014)

Cornal (A) and sagittal (B) MRI sections revealed ahuge well-enhanced mass in the sella turcica.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3973166&req=5

Figure 2: Cornal (A) and sagittal (B) MRI sections revealed ahuge well-enhanced mass in the sella turcica.
Mentions: The results of the GnRH stimulation test manifesteda low response of the serum LH and FSH levels afterthe administration of 0.1 mg GnRH (Fig 1). The karyotype of this patient was 46 XY. The result of a plainMRI scan revealed that the sella turcica was clearly enlarged, which contained an elliptic lump (2.5 ×2.0 ×1.8cm) and appeared as slightly longer T1 and T2 signals.In front of the lump, several cycloid cysts appeared aslong T1 and T2 signals. The basilar part of the sellaturcica clearly sagged and the pituitary stalk was notclearly visible because of space occupation in the sphenoid sinus and sellar area. The optic chiasma was obviously oppressed and its location was moved upward.In addition, the bilateral carotid arteries were encaseddue to oppression of the surrounding tissues. Based onthese signs, a pituitary adenoma was confirmed (Fig 2)

Bottom Line: The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels.The results of the hCG test indicated that T/E2 could recover to a normal level.The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining.

View Article: PubMed Central - PubMed

Affiliation: Reproductive Medicine Center in Qingdao University affiliated Yantai Yuhuangding Hospital, Shandong, China.

ABSTRACT
FSH-secreting pituitary adenomas can affect sexual and reproductive function. In this article, we have reported the case of a 32-year-old male with secondary infertility. The patient had sexual and reproductive disturbances. The test results of the blood samples indicated obviously decreased testosterone (T) and estradiol (E2) levels. Based on previous hormonal results, the patient received pituitary stimulation and human chorionic gonadotropin (hCG) tests. Both follicle stimulating hormone (FSH) and luteinizing hormone (LH) showed low response during the pituitary stimulation test. The results of the hCG test indicated that T/E2 could recover to a normal level. In addition, this patient was diagnosed with pituitary macroadenoma, which was supported by the pituitary MRI. The man's sexual and reproductive functions recovered following surgery. The pathological results confirmed that the tumor tissue was an FSH-secreting pituitary adenoma by immunohistochemical staining. The purpose of this report was to review the relative literature and discuss the influence of FSH-secreting pituitary adenomas on hormones through the hypothalamus-pituitary-testis axis.

No MeSH data available.


Related in: MedlinePlus