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Soluble transferrin receptor-ferritin index in the evaluation of anemia in inflammatory bowel disease: a case-control study.

Oustamanolakis P, Koutroubakis IE, Messaritakis I, Niniraki M, Kouroumalis EA - Ann Gastroenterol (2011)

Bottom Line: Patients with IDA had significantly higher sTfR and sTfR-F index levels compared with those without IDA (P<0.0001).High sTfR levels (>1.8 mg/L) had sensitivity 81% and specificity 80%, whereas high sTfR-F index (>1.4) had sensitivity 91% and specificity 92% for the diagnosis of IDA.These results suggest that the sTfR-F index seems to be very efficient in the detection and diagnosis of IDA, among patients with IBD.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology (Pantelis Oustamanolakis, Ioannis E. Koutroubakis, Elias A. Kouroumalis).

ABSTRACT

Background: No reliable biochemical markers exist for the differentiation between iron deficiency anemia (IDA) and anemia of chronic disease (ACD) in the setting of inflammatory bowel disease (IBD). The aim of this study was to investigate the use of soluble transferrin receptor (sTfR) and sTfR-ferritin (sTfR-F) index in the evaluation of anemia in patients with IBD.

Methods: One hundred IBD patients [49 ulcerative colitis (UC), 51 Crohn's disease (CD)] and 102 healthy controls were enrolled. Serum levels of ferritin, transferrin saturation and sTfR were analyzed in all patients and controls. sTfR-F index was calculated based on the ratio: sTfR/ log ferritin. The value of sTfR and sTfR-F for diagnosis of IDA was assessed.

Results: Forty two IBD patients (41% of UC and 42.9 % of CD) fulfilled the WHO criteria for the diagnosis of anemia. Among them thirty (30 %) had IDA, four (4%) had ACD and eight (8%) had mixed IDA/ACD. Patients with IDA had significantly higher sTfR and sTfR-F index levels compared with those without IDA (P<0.0001). Both sTfR and sTfR-F index were not correlated with CRP levels or disease activity. High sTfR levels (>1.8 mg/L) had sensitivity 81% and specificity 80%, whereas high sTfR-F index (>1.4) had sensitivity 91% and specificity 92% for the diagnosis of IDA.

Conclusion: These results suggest that the sTfR-F index seems to be very efficient in the detection and diagnosis of IDA, among patients with IBD.

No MeSH data available.


Related in: MedlinePlus

Receiver operating characteristic (ROC) curves for soluble transferrin receptor (sTfR) and sTfR –ferritin (sTfRF) index, in the diagnosis of iron deficiency anemia in patients with inflammatory bowel disease
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Figure 3: Receiver operating characteristic (ROC) curves for soluble transferrin receptor (sTfR) and sTfR –ferritin (sTfRF) index, in the diagnosis of iron deficiency anemia in patients with inflammatory bowel disease

Mentions: The ability of sTfR and sTfR-F index to identify IDA among IBD patients with anemia compared to IBD patients without anemia was examined by means of receiver operating characteristic (ROC) analysis (Fig. 3). The sensitivity of high sTfR levels for diagnosis IDA using a cutoff of 1.8 mg/L was 81%, the specificity was 80%, whereas positive predictive value was 63% and negative predictive value was 91%. The sensitivity of high sTfR-F index for diagnosis IDA using a cutoff of 1.4 was 91% and the specificity was 92%, whereas positive predictive value was 83% and negative predictive value was 96%.


Soluble transferrin receptor-ferritin index in the evaluation of anemia in inflammatory bowel disease: a case-control study.

Oustamanolakis P, Koutroubakis IE, Messaritakis I, Niniraki M, Kouroumalis EA - Ann Gastroenterol (2011)

Receiver operating characteristic (ROC) curves for soluble transferrin receptor (sTfR) and sTfR –ferritin (sTfRF) index, in the diagnosis of iron deficiency anemia in patients with inflammatory bowel disease
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3959302&req=5

Figure 3: Receiver operating characteristic (ROC) curves for soluble transferrin receptor (sTfR) and sTfR –ferritin (sTfRF) index, in the diagnosis of iron deficiency anemia in patients with inflammatory bowel disease
Mentions: The ability of sTfR and sTfR-F index to identify IDA among IBD patients with anemia compared to IBD patients without anemia was examined by means of receiver operating characteristic (ROC) analysis (Fig. 3). The sensitivity of high sTfR levels for diagnosis IDA using a cutoff of 1.8 mg/L was 81%, the specificity was 80%, whereas positive predictive value was 63% and negative predictive value was 91%. The sensitivity of high sTfR-F index for diagnosis IDA using a cutoff of 1.4 was 91% and the specificity was 92%, whereas positive predictive value was 83% and negative predictive value was 96%.

Bottom Line: Patients with IDA had significantly higher sTfR and sTfR-F index levels compared with those without IDA (P<0.0001).High sTfR levels (>1.8 mg/L) had sensitivity 81% and specificity 80%, whereas high sTfR-F index (>1.4) had sensitivity 91% and specificity 92% for the diagnosis of IDA.These results suggest that the sTfR-F index seems to be very efficient in the detection and diagnosis of IDA, among patients with IBD.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology (Pantelis Oustamanolakis, Ioannis E. Koutroubakis, Elias A. Kouroumalis).

ABSTRACT

Background: No reliable biochemical markers exist for the differentiation between iron deficiency anemia (IDA) and anemia of chronic disease (ACD) in the setting of inflammatory bowel disease (IBD). The aim of this study was to investigate the use of soluble transferrin receptor (sTfR) and sTfR-ferritin (sTfR-F) index in the evaluation of anemia in patients with IBD.

Methods: One hundred IBD patients [49 ulcerative colitis (UC), 51 Crohn's disease (CD)] and 102 healthy controls were enrolled. Serum levels of ferritin, transferrin saturation and sTfR were analyzed in all patients and controls. sTfR-F index was calculated based on the ratio: sTfR/ log ferritin. The value of sTfR and sTfR-F for diagnosis of IDA was assessed.

Results: Forty two IBD patients (41% of UC and 42.9 % of CD) fulfilled the WHO criteria for the diagnosis of anemia. Among them thirty (30 %) had IDA, four (4%) had ACD and eight (8%) had mixed IDA/ACD. Patients with IDA had significantly higher sTfR and sTfR-F index levels compared with those without IDA (P<0.0001). Both sTfR and sTfR-F index were not correlated with CRP levels or disease activity. High sTfR levels (>1.8 mg/L) had sensitivity 81% and specificity 80%, whereas high sTfR-F index (>1.4) had sensitivity 91% and specificity 92% for the diagnosis of IDA.

Conclusion: These results suggest that the sTfR-F index seems to be very efficient in the detection and diagnosis of IDA, among patients with IBD.

No MeSH data available.


Related in: MedlinePlus