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Soluble transferrin receptor-ferritin index in the evaluation of anemia in inflammatory bowel disease: a case-control study.

Oustamanolakis P, Koutroubakis IE, Messaritakis I, Niniraki M, Kouroumalis EA - Ann Gastroenterol (2011)

Bottom Line: Patients with IDA had significantly higher sTfR and sTfR-F index levels compared with those without IDA (P<0.0001).High sTfR levels (>1.8 mg/L) had sensitivity 81% and specificity 80%, whereas high sTfR-F index (>1.4) had sensitivity 91% and specificity 92% for the diagnosis of IDA.These results suggest that the sTfR-F index seems to be very efficient in the detection and diagnosis of IDA, among patients with IBD.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology (Pantelis Oustamanolakis, Ioannis E. Koutroubakis, Elias A. Kouroumalis).

ABSTRACT

Background: No reliable biochemical markers exist for the differentiation between iron deficiency anemia (IDA) and anemia of chronic disease (ACD) in the setting of inflammatory bowel disease (IBD). The aim of this study was to investigate the use of soluble transferrin receptor (sTfR) and sTfR-ferritin (sTfR-F) index in the evaluation of anemia in patients with IBD.

Methods: One hundred IBD patients [49 ulcerative colitis (UC), 51 Crohn's disease (CD)] and 102 healthy controls were enrolled. Serum levels of ferritin, transferrin saturation and sTfR were analyzed in all patients and controls. sTfR-F index was calculated based on the ratio: sTfR/ log ferritin. The value of sTfR and sTfR-F for diagnosis of IDA was assessed.

Results: Forty two IBD patients (41% of UC and 42.9 % of CD) fulfilled the WHO criteria for the diagnosis of anemia. Among them thirty (30 %) had IDA, four (4%) had ACD and eight (8%) had mixed IDA/ACD. Patients with IDA had significantly higher sTfR and sTfR-F index levels compared with those without IDA (P<0.0001). Both sTfR and sTfR-F index were not correlated with CRP levels or disease activity. High sTfR levels (>1.8 mg/L) had sensitivity 81% and specificity 80%, whereas high sTfR-F index (>1.4) had sensitivity 91% and specificity 92% for the diagnosis of IDA.

Conclusion: These results suggest that the sTfR-F index seems to be very efficient in the detection and diagnosis of IDA, among patients with IBD.

No MeSH data available.


Related in: MedlinePlus

Distribution of soluble transferrin receptor (sTfR) levels in patients with inflammatory bowel disease (IBD) and iron deficiency anemia (IDA, n=30) and IBD patients without IDA (Non IDA, n=70). Boxes indicate the interquartile range with median value. Bars show the 5th and 95th percentiles.
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Figure 1: Distribution of soluble transferrin receptor (sTfR) levels in patients with inflammatory bowel disease (IBD) and iron deficiency anemia (IDA, n=30) and IBD patients without IDA (Non IDA, n=70). Boxes indicate the interquartile range with median value. Bars show the 5th and 95th percentiles.

Mentions: Patients with IDA had significantly higher sTfR levels compared with those without IDA (patients with other causes of anemia and patients without anemia) [median 2.6 mg/L (range 1.2-6.8 mg/L) vs. 1.2 mg/L (0.7-3.1 mg/L), P<0.0001)] (Fig. 1). Similarly, patients with IDA had significantly higher sTfR-F index compared with those without IDA [2.9 (1.0-11.8) vs. 0.7 (0.4-2.8), P<0.0001)] (Fig. 2). Moreover, IBD patients with IDA had significantly higher sTfR and sTfR-F index levels compared with IBD patients with ACD (including mixed IDA/ACD) (P<0.0001).


Soluble transferrin receptor-ferritin index in the evaluation of anemia in inflammatory bowel disease: a case-control study.

Oustamanolakis P, Koutroubakis IE, Messaritakis I, Niniraki M, Kouroumalis EA - Ann Gastroenterol (2011)

Distribution of soluble transferrin receptor (sTfR) levels in patients with inflammatory bowel disease (IBD) and iron deficiency anemia (IDA, n=30) and IBD patients without IDA (Non IDA, n=70). Boxes indicate the interquartile range with median value. Bars show the 5th and 95th percentiles.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3959302&req=5

Figure 1: Distribution of soluble transferrin receptor (sTfR) levels in patients with inflammatory bowel disease (IBD) and iron deficiency anemia (IDA, n=30) and IBD patients without IDA (Non IDA, n=70). Boxes indicate the interquartile range with median value. Bars show the 5th and 95th percentiles.
Mentions: Patients with IDA had significantly higher sTfR levels compared with those without IDA (patients with other causes of anemia and patients without anemia) [median 2.6 mg/L (range 1.2-6.8 mg/L) vs. 1.2 mg/L (0.7-3.1 mg/L), P<0.0001)] (Fig. 1). Similarly, patients with IDA had significantly higher sTfR-F index compared with those without IDA [2.9 (1.0-11.8) vs. 0.7 (0.4-2.8), P<0.0001)] (Fig. 2). Moreover, IBD patients with IDA had significantly higher sTfR and sTfR-F index levels compared with IBD patients with ACD (including mixed IDA/ACD) (P<0.0001).

Bottom Line: Patients with IDA had significantly higher sTfR and sTfR-F index levels compared with those without IDA (P<0.0001).High sTfR levels (>1.8 mg/L) had sensitivity 81% and specificity 80%, whereas high sTfR-F index (>1.4) had sensitivity 91% and specificity 92% for the diagnosis of IDA.These results suggest that the sTfR-F index seems to be very efficient in the detection and diagnosis of IDA, among patients with IBD.

View Article: PubMed Central - PubMed

Affiliation: Department of Gastroenterology (Pantelis Oustamanolakis, Ioannis E. Koutroubakis, Elias A. Kouroumalis).

ABSTRACT

Background: No reliable biochemical markers exist for the differentiation between iron deficiency anemia (IDA) and anemia of chronic disease (ACD) in the setting of inflammatory bowel disease (IBD). The aim of this study was to investigate the use of soluble transferrin receptor (sTfR) and sTfR-ferritin (sTfR-F) index in the evaluation of anemia in patients with IBD.

Methods: One hundred IBD patients [49 ulcerative colitis (UC), 51 Crohn's disease (CD)] and 102 healthy controls were enrolled. Serum levels of ferritin, transferrin saturation and sTfR were analyzed in all patients and controls. sTfR-F index was calculated based on the ratio: sTfR/ log ferritin. The value of sTfR and sTfR-F for diagnosis of IDA was assessed.

Results: Forty two IBD patients (41% of UC and 42.9 % of CD) fulfilled the WHO criteria for the diagnosis of anemia. Among them thirty (30 %) had IDA, four (4%) had ACD and eight (8%) had mixed IDA/ACD. Patients with IDA had significantly higher sTfR and sTfR-F index levels compared with those without IDA (P<0.0001). Both sTfR and sTfR-F index were not correlated with CRP levels or disease activity. High sTfR levels (>1.8 mg/L) had sensitivity 81% and specificity 80%, whereas high sTfR-F index (>1.4) had sensitivity 91% and specificity 92% for the diagnosis of IDA.

Conclusion: These results suggest that the sTfR-F index seems to be very efficient in the detection and diagnosis of IDA, among patients with IBD.

No MeSH data available.


Related in: MedlinePlus