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Designing and implementing bioimpedance spectroscopy device by measuring impedance in a mouse tissue.

Dastjerdi HM, Soltanzadeh R, Rabbani H - J Med Signals Sens (2013)

Bottom Line: Studies show that any complications including hemorrhage, lack of blood supply, lack of oxygen supply and death of cells in a tissue, will have a clear effect on electrical properties of that tissue.Thus, by measuring impedance of a set of tissues, potential problems of the damaged tissue may be found.Thus, with this hardware created, it shows that there are significant impedance changes between mouse tissues.

View Article: PubMed Central - PubMed

Affiliation: Medical Image and Signal processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT
Studies show that any complications including hemorrhage, lack of blood supply, lack of oxygen supply and death of cells in a tissue, will have a clear effect on electrical properties of that tissue. Thus, by measuring impedance of a set of tissues, potential problems of the damaged tissue may be found. Since electrical impedance is closely related to the measuring frequency, obviously, every tissue exhibits its own specific impedance according to its electrical properties at each frequency. This research project investigates design and manufacture method of a device for measuring tissue impedance at different frequencies. To this end, design of a multi frequency sinusoidal current source is required. This current source is built using a single harmonic Generator sample (Direct Digital Synthesizer AD9835) with working frequency (design-point frequency) between 1 Hz and 10 MHz and accuracy of 1 Hz and microcontroller (PIC16F628) capability. For measurement and display of tissue impedance, ARM AT91SAMs256 microcontroller was used. Thus, with this hardware created, it shows that there are significant impedance changes between mouse tissues.

No MeSH data available.


Measuring the impedance of, tissues of a healthy mouse was investigated
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Figure 8: Measuring the impedance of, tissues of a healthy mouse was investigated

Mentions: Figure 7 shows general flowchart of proposed multi-frequency current source for measurement of bioimpedance. In order to show the ability of our device in measuring the impedance, the tissues of a healthy mouse was investigated [Figure 8]. Figures 9-12 show the result of testing bioimpedance for Gastrocnemius muscle, Skin, liver and Heart tissues. All of this measurement was repeated 5 times for each frequency. In Figure 9, the value of the heart impedance was practically noting between 10 HZ and 300 HZ. From this part onwards, impedance reached a peak of 0.200 at 700 Hz. The value of the liver impedance was reported with a sharp rising trend. This measuring was followed by value of the Gastrocnemius muscle impedance in Figure 11 with two exceptions. Value of the skin impedance does not show any steady trend.


Designing and implementing bioimpedance spectroscopy device by measuring impedance in a mouse tissue.

Dastjerdi HM, Soltanzadeh R, Rabbani H - J Med Signals Sens (2013)

Measuring the impedance of, tissues of a healthy mouse was investigated
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3959010&req=5

Figure 8: Measuring the impedance of, tissues of a healthy mouse was investigated
Mentions: Figure 7 shows general flowchart of proposed multi-frequency current source for measurement of bioimpedance. In order to show the ability of our device in measuring the impedance, the tissues of a healthy mouse was investigated [Figure 8]. Figures 9-12 show the result of testing bioimpedance for Gastrocnemius muscle, Skin, liver and Heart tissues. All of this measurement was repeated 5 times for each frequency. In Figure 9, the value of the heart impedance was practically noting between 10 HZ and 300 HZ. From this part onwards, impedance reached a peak of 0.200 at 700 Hz. The value of the liver impedance was reported with a sharp rising trend. This measuring was followed by value of the Gastrocnemius muscle impedance in Figure 11 with two exceptions. Value of the skin impedance does not show any steady trend.

Bottom Line: Studies show that any complications including hemorrhage, lack of blood supply, lack of oxygen supply and death of cells in a tissue, will have a clear effect on electrical properties of that tissue.Thus, by measuring impedance of a set of tissues, potential problems of the damaged tissue may be found.Thus, with this hardware created, it shows that there are significant impedance changes between mouse tissues.

View Article: PubMed Central - PubMed

Affiliation: Medical Image and Signal processing Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

ABSTRACT
Studies show that any complications including hemorrhage, lack of blood supply, lack of oxygen supply and death of cells in a tissue, will have a clear effect on electrical properties of that tissue. Thus, by measuring impedance of a set of tissues, potential problems of the damaged tissue may be found. Since electrical impedance is closely related to the measuring frequency, obviously, every tissue exhibits its own specific impedance according to its electrical properties at each frequency. This research project investigates design and manufacture method of a device for measuring tissue impedance at different frequencies. To this end, design of a multi frequency sinusoidal current source is required. This current source is built using a single harmonic Generator sample (Direct Digital Synthesizer AD9835) with working frequency (design-point frequency) between 1 Hz and 10 MHz and accuracy of 1 Hz and microcontroller (PIC16F628) capability. For measurement and display of tissue impedance, ARM AT91SAMs256 microcontroller was used. Thus, with this hardware created, it shows that there are significant impedance changes between mouse tissues.

No MeSH data available.