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Elevated Th22 cells correlated with Th17 cells in peripheral blood of patients with acute myeloid leukemia.

Yu S, Liu C, Zhang L, Shan B, Tian T, Hu Y, Shao L, Sun Y, Ji C, Ma D - Int J Mol Sci (2014)

Bottom Line: We demonstrated that Th22, Th17, and pure Th17 in newly-diagnosed (ND) and non-complete remission (Non-CR) AML patients and plasma IL-22 in ND AML patients were significantly increased.Retinoid-related orphan receptor C (RORC) expression was significantly elevated in CR and Non-CR AML patients.However, Th1 in ND AML patients and IL-17 in ND, Non-CR or CR AML patients was significantly decreased compared with controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. yussdu@gmail.com.

ABSTRACT
Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear. Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. We demonstrated that Th22, Th17, and pure Th17 in newly-diagnosed (ND) and non-complete remission (Non-CR) AML patients and plasma IL-22 in ND AML patients were significantly increased. Retinoid-related orphan receptor C (RORC) expression was significantly elevated in CR and Non-CR AML patients. However, Th1 in ND AML patients and IL-17 in ND, Non-CR or CR AML patients was significantly decreased compared with controls. Moreover, Th22 and IL-22 showed positive correlation with pure Th17, but Th22 showed negative correlation with Th1 in ND AML patients. RORC showed positive correlation with Th22 and approximately positive correlation with pure Th17 in Non-CR patients. PB blast cell showed positive correlation with Th22 and negative correlation with Th1 in ND AML patients. Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising novel clinical index for AML.

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Comparison of Th subsets in different AML patients. Th22 (A); pure Th17 (B); and Th17 cells (C) were significantly increased in acute myelomonocytic leukemia patients compared with acute monocytic leukemia patients; (D) No significant difference of Th1 cells was found in different AML patients. Data was shown as Median (range). *p < 0.05.
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f8-ijms-15-01927: Comparison of Th subsets in different AML patients. Th22 (A); pure Th17 (B); and Th17 cells (C) were significantly increased in acute myelomonocytic leukemia patients compared with acute monocytic leukemia patients; (D) No significant difference of Th1 cells was found in different AML patients. Data was shown as Median (range). *p < 0.05.

Mentions: We compared Th subsets from APL with PML-RARA, AML with maturation, acute myelomonocytic leukemia, and acute monocytic leukemia. As shown in Figure 8A, the frequencies of Th22 were significantly increased in acute myelomonocytic leukemia patients (median, 2.55% (range, 0.76%–3.98%)) compared with acute monocytic leukemia patients (median, 1.29% (range, 0.58%–2.18%), p = 0.0365). Moreover, Th17 and pure Th17 cells were also higher in acute myelomonocytic leukemia patients (4.08% ± 1.15%; 3.07% ± 1.33%) than acute monocytic leukemia patients (3.18% ± 1.02%, p = 0.0463; 1.85% ± 0.89%, p = 0.0118) (Figure 8B,C). However, no significant difference of Th1 cells was found in different AML patients (p > 0.05) (Figure 8D).


Elevated Th22 cells correlated with Th17 cells in peripheral blood of patients with acute myeloid leukemia.

Yu S, Liu C, Zhang L, Shan B, Tian T, Hu Y, Shao L, Sun Y, Ji C, Ma D - Int J Mol Sci (2014)

Comparison of Th subsets in different AML patients. Th22 (A); pure Th17 (B); and Th17 cells (C) were significantly increased in acute myelomonocytic leukemia patients compared with acute monocytic leukemia patients; (D) No significant difference of Th1 cells was found in different AML patients. Data was shown as Median (range). *p < 0.05.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3958830&req=5

f8-ijms-15-01927: Comparison of Th subsets in different AML patients. Th22 (A); pure Th17 (B); and Th17 cells (C) were significantly increased in acute myelomonocytic leukemia patients compared with acute monocytic leukemia patients; (D) No significant difference of Th1 cells was found in different AML patients. Data was shown as Median (range). *p < 0.05.
Mentions: We compared Th subsets from APL with PML-RARA, AML with maturation, acute myelomonocytic leukemia, and acute monocytic leukemia. As shown in Figure 8A, the frequencies of Th22 were significantly increased in acute myelomonocytic leukemia patients (median, 2.55% (range, 0.76%–3.98%)) compared with acute monocytic leukemia patients (median, 1.29% (range, 0.58%–2.18%), p = 0.0365). Moreover, Th17 and pure Th17 cells were also higher in acute myelomonocytic leukemia patients (4.08% ± 1.15%; 3.07% ± 1.33%) than acute monocytic leukemia patients (3.18% ± 1.02%, p = 0.0463; 1.85% ± 0.89%, p = 0.0118) (Figure 8B,C). However, no significant difference of Th1 cells was found in different AML patients (p > 0.05) (Figure 8D).

Bottom Line: We demonstrated that Th22, Th17, and pure Th17 in newly-diagnosed (ND) and non-complete remission (Non-CR) AML patients and plasma IL-22 in ND AML patients were significantly increased.Retinoid-related orphan receptor C (RORC) expression was significantly elevated in CR and Non-CR AML patients.However, Th1 in ND AML patients and IL-17 in ND, Non-CR or CR AML patients was significantly decreased compared with controls.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan 250012, China. yussdu@gmail.com.

ABSTRACT
Acute myeloid leukemia (AML) is a hematological tumor in which progress T helper (Th) subsets including Th22, Th17, and Th1 cells play a pivotal role. However, the role of T helper (Th) subsets in the immune pathogenesis of AML remains unclear. Here, we investigated frequencies of Th22, Th17, pure Th17, and Th1 cells in the peripheral blood (PB) of AML patients. We demonstrated that Th22, Th17, and pure Th17 in newly-diagnosed (ND) and non-complete remission (Non-CR) AML patients and plasma IL-22 in ND AML patients were significantly increased. Retinoid-related orphan receptor C (RORC) expression was significantly elevated in CR and Non-CR AML patients. However, Th1 in ND AML patients and IL-17 in ND, Non-CR or CR AML patients was significantly decreased compared with controls. Moreover, Th22 and IL-22 showed positive correlation with pure Th17, but Th22 showed negative correlation with Th1 in ND AML patients. RORC showed positive correlation with Th22 and approximately positive correlation with pure Th17 in Non-CR patients. PB blast cell showed positive correlation with Th22 and negative correlation with Th1 in ND AML patients. Our results indicate that Th22 and pure Th17 cells conjointly contribute to the pathogenesis of AML and might be promising novel clinical index for AML.

Show MeSH
Related in: MedlinePlus