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Characterization of the Schistosoma transcriptome opens up the world of helminth genomics.

Hoffmann KF, Dunne DW - Genome Biol. (2003)

Bottom Line: Among the metazoan parasites that cause debilitating disease in man, schistosomes are the first group for which near-complete transcriptome complements have been described.This new genomic information will have an enormous impact on all future investigations into the biology, pathogenesis and control of schistosomiasis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. kfh24@cam.ac.uk

ABSTRACT
Among the metazoan parasites that cause debilitating disease in man, schistosomes are the first group for which near-complete transcriptome complements have been described. This new genomic information will have an enormous impact on all future investigations into the biology, pathogenesis and control of schistosomiasis.

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Related in: MedlinePlus

The schistosome life cycle. Schistosomes reproduce asexually in freshwater snails; a larval form, the cercaria, is released from the snail and can burrow into the skin of the definitive host, man. In humans, schistosomes migrate to the bloodstream where they mature into adult worms. Eggs produced by the female worm are released into the environment where they hatch into a second larval form, the miracidia, which can infect the snail. Adapted and reproduced with permission from [28].
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Figure 1: The schistosome life cycle. Schistosomes reproduce asexually in freshwater snails; a larval form, the cercaria, is released from the snail and can burrow into the skin of the definitive host, man. In humans, schistosomes migrate to the bloodstream where they mature into adult worms. Eggs produced by the female worm are released into the environment where they hatch into a second larval form, the miracidia, which can infect the snail. Adapted and reproduced with permission from [28].

Mentions: Schistosomes have many features characteristic of the trematode group as a whole, yet are atypical in that the adult worms are dioecious, having both male and female forms. The schistosome life-cycle involves two distinct phases (Figure 1): asexual reproduction in the intermediate host, a freshwater snail, and sexual reproduction in the blood of the definitive host (man and other mammals). The miracidia and cercaria larvae are morphologically distinct, free-living, water-borne forms that traverse between the snail and mammalian hosts. Indeed, schistosomes reveal a truly astonishing morphological and physiological plasticity as they move from one highly specialized developmental stage to another.


Characterization of the Schistosoma transcriptome opens up the world of helminth genomics.

Hoffmann KF, Dunne DW - Genome Biol. (2003)

The schistosome life cycle. Schistosomes reproduce asexually in freshwater snails; a larval form, the cercaria, is released from the snail and can burrow into the skin of the definitive host, man. In humans, schistosomes migrate to the bloodstream where they mature into adult worms. Eggs produced by the female worm are released into the environment where they hatch into a second larval form, the miracidia, which can infect the snail. Adapted and reproduced with permission from [28].
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC395727&req=5

Figure 1: The schistosome life cycle. Schistosomes reproduce asexually in freshwater snails; a larval form, the cercaria, is released from the snail and can burrow into the skin of the definitive host, man. In humans, schistosomes migrate to the bloodstream where they mature into adult worms. Eggs produced by the female worm are released into the environment where they hatch into a second larval form, the miracidia, which can infect the snail. Adapted and reproduced with permission from [28].
Mentions: Schistosomes have many features characteristic of the trematode group as a whole, yet are atypical in that the adult worms are dioecious, having both male and female forms. The schistosome life-cycle involves two distinct phases (Figure 1): asexual reproduction in the intermediate host, a freshwater snail, and sexual reproduction in the blood of the definitive host (man and other mammals). The miracidia and cercaria larvae are morphologically distinct, free-living, water-borne forms that traverse between the snail and mammalian hosts. Indeed, schistosomes reveal a truly astonishing morphological and physiological plasticity as they move from one highly specialized developmental stage to another.

Bottom Line: Among the metazoan parasites that cause debilitating disease in man, schistosomes are the first group for which near-complete transcriptome complements have been described.This new genomic information will have an enormous impact on all future investigations into the biology, pathogenesis and control of schistosomiasis.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. kfh24@cam.ac.uk

ABSTRACT
Among the metazoan parasites that cause debilitating disease in man, schistosomes are the first group for which near-complete transcriptome complements have been described. This new genomic information will have an enormous impact on all future investigations into the biology, pathogenesis and control of schistosomiasis.

Show MeSH
Related in: MedlinePlus