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The angiotensinogen gene polymorphism is associated with heart failure among Asians.

Jiang WL, He HW, Yang ZJ - Sci Rep (2014)

Bottom Line: However, association studies on the M235T polymorphism and HF risk have shown conflicting results.In contrast, in the HF subgroup analysis by ethnicity, the AGT M235T polymorphism had a decreased risk of HF among Asians (MT vs.Our results suggest that the AGT M235T polymorphism is a low-penetrant risk factor for the development of HF among Asians.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China [2] Department of Cardiology, The Affiliated Jiangyin hospital of Medical College of Southeast University, Wuxi 214400, China.

ABSTRACT
The angiotensinogen (AGT) gene M235T polymorphism has been suggested to be linked to risk of heart failure (HF). However, association studies on the M235T polymorphism and HF risk have shown conflicting results. PubMed and China Biology Medicine (CBM) databases were systematically searched to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. A total of 1,281 HF cases and 1,376 controls were included in the analysis. The pooled data showed that there was no significant associations between the AGT M235T polymorphism and HF risk for TT vs. MM (OR = 1.17, 95%CI = 0.62-2.19, P = 0.635), MT vs. MM (OR = 0.97, 95%CI = 0.77-1.22, P = 0.776), MT/TT vs. MM (OR = 1.07, 95%CI = 0.67-1.69, P = 0.781), and TT vs. MM/MT (OR = 1.23, 95%CI = 0.86-1.76, P = 0.259). In contrast, in the HF subgroup analysis by ethnicity, the AGT M235T polymorphism had a decreased risk of HF among Asians (MT vs. MM, OR = 0.39, 95%CI = 0.17-0.92, P = 0.032). Our results suggest that the AGT M235T polymorphism is a low-penetrant risk factor for the development of HF among Asians.

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The flow chart of the included studies.
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f1: The flow chart of the included studies.

Mentions: There were 57 published papers relevant to the search words. Based on the inclusion criteria, only six case-control studies were selected for this meta-analysis [9–26], and 41 studies were excluded. The flow chart of the study selection is summarized in Fig. 1. These selected studies included 1,281 cases and 1,376 control subjects. All studies were case-control studies that evaluated the association between the AGT M235T polymorphism and HF risk91011121314. The distribution of genotypes in the controls of each study was in agreement with Hardy-Weinberg equilibrium except for one study9. Of these case-control studies, three reported on Europeans, while three reports were on Asians (Table 2).


The angiotensinogen gene polymorphism is associated with heart failure among Asians.

Jiang WL, He HW, Yang ZJ - Sci Rep (2014)

The flow chart of the included studies.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3936209&req=5

f1: The flow chart of the included studies.
Mentions: There were 57 published papers relevant to the search words. Based on the inclusion criteria, only six case-control studies were selected for this meta-analysis [9–26], and 41 studies were excluded. The flow chart of the study selection is summarized in Fig. 1. These selected studies included 1,281 cases and 1,376 control subjects. All studies were case-control studies that evaluated the association between the AGT M235T polymorphism and HF risk91011121314. The distribution of genotypes in the controls of each study was in agreement with Hardy-Weinberg equilibrium except for one study9. Of these case-control studies, three reported on Europeans, while three reports were on Asians (Table 2).

Bottom Line: However, association studies on the M235T polymorphism and HF risk have shown conflicting results.In contrast, in the HF subgroup analysis by ethnicity, the AGT M235T polymorphism had a decreased risk of HF among Asians (MT vs.Our results suggest that the AGT M235T polymorphism is a low-penetrant risk factor for the development of HF among Asians.

View Article: PubMed Central - PubMed

Affiliation: 1] Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China [2] Department of Cardiology, The Affiliated Jiangyin hospital of Medical College of Southeast University, Wuxi 214400, China.

ABSTRACT
The angiotensinogen (AGT) gene M235T polymorphism has been suggested to be linked to risk of heart failure (HF). However, association studies on the M235T polymorphism and HF risk have shown conflicting results. PubMed and China Biology Medicine (CBM) databases were systematically searched to identify relevant studies. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association. A total of 1,281 HF cases and 1,376 controls were included in the analysis. The pooled data showed that there was no significant associations between the AGT M235T polymorphism and HF risk for TT vs. MM (OR = 1.17, 95%CI = 0.62-2.19, P = 0.635), MT vs. MM (OR = 0.97, 95%CI = 0.77-1.22, P = 0.776), MT/TT vs. MM (OR = 1.07, 95%CI = 0.67-1.69, P = 0.781), and TT vs. MM/MT (OR = 1.23, 95%CI = 0.86-1.76, P = 0.259). In contrast, in the HF subgroup analysis by ethnicity, the AGT M235T polymorphism had a decreased risk of HF among Asians (MT vs. MM, OR = 0.39, 95%CI = 0.17-0.92, P = 0.032). Our results suggest that the AGT M235T polymorphism is a low-penetrant risk factor for the development of HF among Asians.

Show MeSH
Related in: MedlinePlus