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An incidentally diagnosed prostatic ductal adenocarcinoma.

Stajno P, Kalinowski T, Ligaj M, Demkow T - Cent European J Urol (2013)

Bottom Line: DAP is associated with more aggressive natural history and worse prognosis than pure AA - patients presented at more advanced stage, with poorly differentiated and distant disease.DAP has a tendency to spread to regional lymph nodes, axial skeleton, and visceral organs.The pathological examination of the specimens revealed a dominant focus of DAP, which was located near the intraprostatic urethra and a coexisting, smaller component of "classic" acinar adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: Urooncology Department, Maria Skłodowska-Curie Memorial Cancer Hospital, Warsaw, Poland.

ABSTRACT
Ductal adenocarcinoma of the prostate was initially described in 1967 by Melicow and Patcher. It was given the erroneous name endometrioid carcinoma, however, further studies confirmed the prostatic origin of this tumor. Currently DAP is classified as a histological variant of prostatic carcinoma. Compared with "classic" acinar carcinoma of the prostate, DAP is a rare histological finding. It's prevalence in prostatectomy and biopsy specimens varies from less than 1% for pure ductal adenocarcinoma up to 5% for mixed DAP. Because of its typical periurethral location, the tumor usually manifests itself clinically with urinary obstruction, urinary urgency, urinary frequency and hematuria. DAP is associated with more aggressive natural history and worse prognosis than pure AA - patients presented at more advanced stage, with poorly differentiated and distant disease. DAP has a tendency to spread to regional lymph nodes, axial skeleton, and visceral organs. We report a case of a 90-year old man who presented to our clinic with acute urinary retention and gross hematuria. He underwent suprapubic transvesical adenomectomy to diminish the urinary obstruction. The pathological examination of the specimens revealed a dominant focus of DAP, which was located near the intraprostatic urethra and a coexisting, smaller component of "classic" acinar adenocarcinoma.

No MeSH data available.


Related in: MedlinePlus

Ductal adenocarcinoma. Complex papillary cribriform architectural patterns within the prostatic ducts (A, B). Mucosa of the prostatic urethra seen to the left (A), (H&E, low–power magnification, x4).
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Figure 0001: Ductal adenocarcinoma. Complex papillary cribriform architectural patterns within the prostatic ducts (A, B). Mucosa of the prostatic urethra seen to the left (A), (H&E, low–power magnification, x4).

Mentions: A suprapubic transvesical adenomectomy was performed to diminish the urinary obstruction. Two fragments (8 x 5 x 5 cm and 6 x 3.5 x 4.5 cm) of the prostate adenoma were pathologically examined. The specimens contained an approximately 1.4 cm focus of ductal adenocarcinoma with Gleason score 7(3+4), which was located near the intraprostatic urethra (Figures 1 and 2). In the immunohistochemical examination these cancer cells were PSA and PSAP positive, whereas CKHMW negative (Figure 3). Furthermore, a 0.1 cm component of ‘classic’ AA (Gleason score 7(3+4)) was reported. The tumor demonstrated no perineural invasion. The postoperative course was without complications and the patient was discharged on the 7th post–operative day.


An incidentally diagnosed prostatic ductal adenocarcinoma.

Stajno P, Kalinowski T, Ligaj M, Demkow T - Cent European J Urol (2013)

Ductal adenocarcinoma. Complex papillary cribriform architectural patterns within the prostatic ducts (A, B). Mucosa of the prostatic urethra seen to the left (A), (H&E, low–power magnification, x4).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3936143&req=5

Figure 0001: Ductal adenocarcinoma. Complex papillary cribriform architectural patterns within the prostatic ducts (A, B). Mucosa of the prostatic urethra seen to the left (A), (H&E, low–power magnification, x4).
Mentions: A suprapubic transvesical adenomectomy was performed to diminish the urinary obstruction. Two fragments (8 x 5 x 5 cm and 6 x 3.5 x 4.5 cm) of the prostate adenoma were pathologically examined. The specimens contained an approximately 1.4 cm focus of ductal adenocarcinoma with Gleason score 7(3+4), which was located near the intraprostatic urethra (Figures 1 and 2). In the immunohistochemical examination these cancer cells were PSA and PSAP positive, whereas CKHMW negative (Figure 3). Furthermore, a 0.1 cm component of ‘classic’ AA (Gleason score 7(3+4)) was reported. The tumor demonstrated no perineural invasion. The postoperative course was without complications and the patient was discharged on the 7th post–operative day.

Bottom Line: DAP is associated with more aggressive natural history and worse prognosis than pure AA - patients presented at more advanced stage, with poorly differentiated and distant disease.DAP has a tendency to spread to regional lymph nodes, axial skeleton, and visceral organs.The pathological examination of the specimens revealed a dominant focus of DAP, which was located near the intraprostatic urethra and a coexisting, smaller component of "classic" acinar adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: Urooncology Department, Maria Skłodowska-Curie Memorial Cancer Hospital, Warsaw, Poland.

ABSTRACT
Ductal adenocarcinoma of the prostate was initially described in 1967 by Melicow and Patcher. It was given the erroneous name endometrioid carcinoma, however, further studies confirmed the prostatic origin of this tumor. Currently DAP is classified as a histological variant of prostatic carcinoma. Compared with "classic" acinar carcinoma of the prostate, DAP is a rare histological finding. It's prevalence in prostatectomy and biopsy specimens varies from less than 1% for pure ductal adenocarcinoma up to 5% for mixed DAP. Because of its typical periurethral location, the tumor usually manifests itself clinically with urinary obstruction, urinary urgency, urinary frequency and hematuria. DAP is associated with more aggressive natural history and worse prognosis than pure AA - patients presented at more advanced stage, with poorly differentiated and distant disease. DAP has a tendency to spread to regional lymph nodes, axial skeleton, and visceral organs. We report a case of a 90-year old man who presented to our clinic with acute urinary retention and gross hematuria. He underwent suprapubic transvesical adenomectomy to diminish the urinary obstruction. The pathological examination of the specimens revealed a dominant focus of DAP, which was located near the intraprostatic urethra and a coexisting, smaller component of "classic" acinar adenocarcinoma.

No MeSH data available.


Related in: MedlinePlus