Limits...
Metastatic squamous cell carcinoma of the anus to the lung confirmed with allelotyping.

Roth R, Moffatt-Bruce S, Leon ME - Case Rep Pathol (2014)

Bottom Line: Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung.When multiple tumors are present, determining metastatic versus synchronous primary tumors is necessary for appropriate treatment.Identification can be achieved using allelotyping for loss of heterozygosity.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA.

ABSTRACT
Histopathologic techniques are insufficient for distinguishing primary squamous cell carcinoma (SCC) from metastatic SCC, which is clinically important. A patient with SCC of the anus was found to also have SCC of the lung, and the question of metastatic versus synchronous primary diseases was raised. Immunohistochemical and hematoxylin and eosin (H&E) staining on sections of tissue could not discriminate between the two entities. Immunostain for p16 and chromogenic in situ hybridization for human papillomavirus (HPV) type 16 were positive in both tumors. Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung. The patient was treated with palliative chemotherapy instead of additional surgical treatment. When multiple tumors are present, determining metastatic versus synchronous primary tumors is necessary for appropriate treatment. Identification can be achieved using allelotyping for loss of heterozygosity.

No MeSH data available.


Related in: MedlinePlus

Hematoxylin and eosin stained sections of tumors from the anal canal (left) and lung tumor (right) showing the sampled foci. Anal SCC sampled foci: 2T, 3T, and 4T; lung SCC sampled foci: 5T, 6T, and 7T; and lung normal: 1N for the loss of heterozygosity (LOH) allelotyping performed on lung tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3934382&req=5

fig3: Hematoxylin and eosin stained sections of tumors from the anal canal (left) and lung tumor (right) showing the sampled foci. Anal SCC sampled foci: 2T, 3T, and 4T; lung SCC sampled foci: 5T, 6T, and 7T; and lung normal: 1N for the loss of heterozygosity (LOH) allelotyping performed on lung tissue.

Mentions: In the patient described in this case report, both tumors had identical allelic imbalance of 3p and 5q with the same allele copy affected in each specimen. The lung tumor had an additional 17p LOH. These data confirmed a metastatic anal SCC to the lung. The patient is currently clinically stable without signs of recurrent disease (Figure 3).


Metastatic squamous cell carcinoma of the anus to the lung confirmed with allelotyping.

Roth R, Moffatt-Bruce S, Leon ME - Case Rep Pathol (2014)

Hematoxylin and eosin stained sections of tumors from the anal canal (left) and lung tumor (right) showing the sampled foci. Anal SCC sampled foci: 2T, 3T, and 4T; lung SCC sampled foci: 5T, 6T, and 7T; and lung normal: 1N for the loss of heterozygosity (LOH) allelotyping performed on lung tissue.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3934382&req=5

fig3: Hematoxylin and eosin stained sections of tumors from the anal canal (left) and lung tumor (right) showing the sampled foci. Anal SCC sampled foci: 2T, 3T, and 4T; lung SCC sampled foci: 5T, 6T, and 7T; and lung normal: 1N for the loss of heterozygosity (LOH) allelotyping performed on lung tissue.
Mentions: In the patient described in this case report, both tumors had identical allelic imbalance of 3p and 5q with the same allele copy affected in each specimen. The lung tumor had an additional 17p LOH. These data confirmed a metastatic anal SCC to the lung. The patient is currently clinically stable without signs of recurrent disease (Figure 3).

Bottom Line: Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung.When multiple tumors are present, determining metastatic versus synchronous primary tumors is necessary for appropriate treatment.Identification can be achieved using allelotyping for loss of heterozygosity.

View Article: PubMed Central - PubMed

Affiliation: Department of Pathology, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, Columbus, OH 43210, USA.

ABSTRACT
Histopathologic techniques are insufficient for distinguishing primary squamous cell carcinoma (SCC) from metastatic SCC, which is clinically important. A patient with SCC of the anus was found to also have SCC of the lung, and the question of metastatic versus synchronous primary diseases was raised. Immunohistochemical and hematoxylin and eosin (H&E) staining on sections of tissue could not discriminate between the two entities. Immunostain for p16 and chromogenic in situ hybridization for human papillomavirus (HPV) type 16 were positive in both tumors. Additionally, allelotyping for loss of heterozygosity displayed similar findings and confirmed the histopathological impression of anal SCC metastasis to the lung. The patient was treated with palliative chemotherapy instead of additional surgical treatment. When multiple tumors are present, determining metastatic versus synchronous primary tumors is necessary for appropriate treatment. Identification can be achieved using allelotyping for loss of heterozygosity.

No MeSH data available.


Related in: MedlinePlus