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Differential Effects of Single-Dose Escitalopram on Cognitive and Affective Interference during Stroop Task.

Rahm C, Liberg B, Kristoffersen-Wiberg M, Aspelin P, Msghina M - Front Psychiatry (2014)

Bottom Line: Escitalopram significantly decreased the activity in rostral ACC during aStroop compared to cStroop (p < 0.05).In the absence of escitalopram, both aStroop and cStroop significantly activated ACC and DLPFC (Z ≥ 2.3, p < 0.05).We conclude that escitalopram in a region and task specific manner modified the cognitive control networks and preferentially decreased activity induced by affective interference in the ACC.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Neuroscience, Karolinska Institutet , Stockholm , Sweden.

ABSTRACT

Background and objective: Our aim was to study the regulatory role of serotonin [(5-hydroxytryptamine (5-HT)] on two key nodes in the cognitive control networks - the anterior cingulate cortex (ACC) and the dorsolateral prefrontal cortex (DLPFC). We hypothesized that increasing the levels of 5-HT would preferentially modulate the activity in ACC during cognitive control during interference by negative affects compared to cognitive control during interference by a superimposed cognitive task.

Methods: We performed a functional magnetic resonance imaging investigation on 11 healthy individuals, comparing the effects of the selective 5-HT reuptake inhibitor escitalopram on brain oxygenation level dependent signals in the ACC and the DLPFC using affective and cognitive counting Stroop paradigms (aStroop and cStroop).

Results: Escitalopram significantly decreased the activity in rostral ACC during aStroop compared to cStroop (p < 0.05). In the absence of escitalopram, both aStroop and cStroop significantly activated ACC and DLPFC (Z ≥ 2.3, p < 0.05).

Conclusion: We conclude that escitalopram in a region and task specific manner modified the cognitive control networks and preferentially decreased activity induced by affective interference in the ACC.

No MeSH data available.


Related in: MedlinePlus

Blood oxygen level dependant changes in the right ACC. The BOLD percentage changes in the right rostral anterior cingulate cortex for affective counting Stroop (aStroop) and cognitive counting Stroop (cStroop) before and after intake of escitalopram. The differences were not statistically significant. The mask was smoothed with a Gaussian kernel set to 1.5 mm, surrounding the peak voxel shown in Figure 2A (x, y, z: 6, 44, 12).
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Figure 3: Blood oxygen level dependant changes in the right ACC. The BOLD percentage changes in the right rostral anterior cingulate cortex for affective counting Stroop (aStroop) and cognitive counting Stroop (cStroop) before and after intake of escitalopram. The differences were not statistically significant. The mask was smoothed with a Gaussian kernel set to 1.5 mm, surrounding the peak voxel shown in Figure 2A (x, y, z: 6, 44, 12).

Mentions: To compare the effects of escitalopram on aStroop and cStroop in the key nodes of the cognitive control networks, a hypothesis driven ROI analysis was performed post hoc in the ACC and the DLPFC. In the absence of escitalopram, aStroop significantly activated rostral ACC compared to cStroop (aStroop > cStroop, corrected p < 0.05, Table 1C), while cStroop significantly activated dorsal ACC and DLPFC compared to aStroop (cStroop > aStroop, corrected p < 0.05, Tables 1B,C). Ten milligrams of escitalopram decreased the BOLD signal in rostral ACC for the aStroop contrast (aStroop > cStroop, corrected p < 0.05, Table 1B), and left intact the BOLD signal in dorsal ACC and DLPFC for the cStroop contrast (cStroop > aStroop, corrected p < 0.05, Tables 1B,C). When the effects of escitalopram were compared, the rostral ACC during aStroop turned out to be significantly more activated before compared to after drug intake (corrected p < 0.05, Figure 2C). The peak voxel (x, y, z: 6, 44, 12) survived a corrected threshold of p = 0.05 (at the voxel level, using Gaussian random field theory). The difference was primarily driven by the aStroop after > before escitalopram contrast (Figure 3). No other significant difference was noted in the effects of escitalopram in medial or lateral PFC.


Differential Effects of Single-Dose Escitalopram on Cognitive and Affective Interference during Stroop Task.

Rahm C, Liberg B, Kristoffersen-Wiberg M, Aspelin P, Msghina M - Front Psychiatry (2014)

Blood oxygen level dependant changes in the right ACC. The BOLD percentage changes in the right rostral anterior cingulate cortex for affective counting Stroop (aStroop) and cognitive counting Stroop (cStroop) before and after intake of escitalopram. The differences were not statistically significant. The mask was smoothed with a Gaussian kernel set to 1.5 mm, surrounding the peak voxel shown in Figure 2A (x, y, z: 6, 44, 12).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3934307&req=5

Figure 3: Blood oxygen level dependant changes in the right ACC. The BOLD percentage changes in the right rostral anterior cingulate cortex for affective counting Stroop (aStroop) and cognitive counting Stroop (cStroop) before and after intake of escitalopram. The differences were not statistically significant. The mask was smoothed with a Gaussian kernel set to 1.5 mm, surrounding the peak voxel shown in Figure 2A (x, y, z: 6, 44, 12).
Mentions: To compare the effects of escitalopram on aStroop and cStroop in the key nodes of the cognitive control networks, a hypothesis driven ROI analysis was performed post hoc in the ACC and the DLPFC. In the absence of escitalopram, aStroop significantly activated rostral ACC compared to cStroop (aStroop > cStroop, corrected p < 0.05, Table 1C), while cStroop significantly activated dorsal ACC and DLPFC compared to aStroop (cStroop > aStroop, corrected p < 0.05, Tables 1B,C). Ten milligrams of escitalopram decreased the BOLD signal in rostral ACC for the aStroop contrast (aStroop > cStroop, corrected p < 0.05, Table 1B), and left intact the BOLD signal in dorsal ACC and DLPFC for the cStroop contrast (cStroop > aStroop, corrected p < 0.05, Tables 1B,C). When the effects of escitalopram were compared, the rostral ACC during aStroop turned out to be significantly more activated before compared to after drug intake (corrected p < 0.05, Figure 2C). The peak voxel (x, y, z: 6, 44, 12) survived a corrected threshold of p = 0.05 (at the voxel level, using Gaussian random field theory). The difference was primarily driven by the aStroop after > before escitalopram contrast (Figure 3). No other significant difference was noted in the effects of escitalopram in medial or lateral PFC.

Bottom Line: Escitalopram significantly decreased the activity in rostral ACC during aStroop compared to cStroop (p < 0.05).In the absence of escitalopram, both aStroop and cStroop significantly activated ACC and DLPFC (Z ≥ 2.3, p < 0.05).We conclude that escitalopram in a region and task specific manner modified the cognitive control networks and preferentially decreased activity induced by affective interference in the ACC.

View Article: PubMed Central - PubMed

Affiliation: Department of Clinical Neuroscience, Karolinska Institutet , Stockholm , Sweden.

ABSTRACT

Background and objective: Our aim was to study the regulatory role of serotonin [(5-hydroxytryptamine (5-HT)] on two key nodes in the cognitive control networks - the anterior cingulate cortex (ACC) and the dorsolateral prefrontal cortex (DLPFC). We hypothesized that increasing the levels of 5-HT would preferentially modulate the activity in ACC during cognitive control during interference by negative affects compared to cognitive control during interference by a superimposed cognitive task.

Methods: We performed a functional magnetic resonance imaging investigation on 11 healthy individuals, comparing the effects of the selective 5-HT reuptake inhibitor escitalopram on brain oxygenation level dependent signals in the ACC and the DLPFC using affective and cognitive counting Stroop paradigms (aStroop and cStroop).

Results: Escitalopram significantly decreased the activity in rostral ACC during aStroop compared to cStroop (p < 0.05). In the absence of escitalopram, both aStroop and cStroop significantly activated ACC and DLPFC (Z ≥ 2.3, p < 0.05).

Conclusion: We conclude that escitalopram in a region and task specific manner modified the cognitive control networks and preferentially decreased activity induced by affective interference in the ACC.

No MeSH data available.


Related in: MedlinePlus