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Influence of periodontal therapy on C-reactive protein level: a systematic review and meta-analysis.

Freitas CO, Gomes-Filho IS, Naves RC, Nogueira Filho Gda R, Cruz SS, Santos CA, Dunningham L, Miranda LF, Barbosa MD - J Appl Oral Sci (2012)

Bottom Line: The influence of oral infections, especially periodontal disease, on systemic diseases has been extensively discussed in the literature.Because periodontal disease is a persistent infection, it promotes an inflammatory response.The result was statistically significant, without evidence of heterogeneity between the studies (p=0.311).

View Article: PubMed Central - PubMed

Affiliation: Bahia School of Medicine and Public Health, Salvador, BA, Brazil. camila.otf@gmail.com

ABSTRACT

Unlabelled: The influence of oral infections, especially periodontal disease, on systemic diseases has been extensively discussed in the literature. Because periodontal disease is a persistent infection, it promotes an inflammatory response. C-reactive protein is a marker for inflammatory reactions that is frequently studied, since elevated levels of this protein are related to coronary events.

Objective: The aim of this study was to investigate the effect of periodontal therapy on reducing the serum levels of C-reactive protein, by means of a systematic review of the literature and meta-analysis.

Material and methods: A systematic review of the English-language literature was conducted in the PUBMED-MEDLINE database, using the key words "periodontal disease", "C-reactive protein", "periodontal therapy" and "periodontal treatment", in accordance with the terms for Medical Subject Headings (MeSH), to evaluate the effect of periodontal therapy on C-reactive protein levels. A qualitative analysis of studies of randomized clinical trial design was performed using CONSORT, with subsequent meta-analysis.

Results: The literature search initially retrieved 46 potentially relevant studies available in the databases. From these, in accordance with the inclusion criteria, only 11 were selected, of which only 4 fulfilled the criteria of randomized clinical trial design. According to CONSORT, the studies evaluated generally presented good quality with regard to the criteria analyzed. Through meta-analysis, the reduction in mean levels of C-reactive protein (-0.231; p=0.000) after introducing periodontal treatment was estimated. The result was statistically significant, without evidence of heterogeneity between the studies (p=0.311).

Conclusions: The findings indicated that non-surgical periodontal treatment had a positive effect with regard to reduction of the serum levels of C-reactive protein.

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Related in: MedlinePlus

Article selection and inclusion process
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f02: Article selection and inclusion process

Mentions: All English-language articles dealing with the effects of periodontal therapy on theserum levels of C-reactive protein among humans were selected, independent of theperiodontal therapy applied. The selection was also made according to study design,searching for clinical trials. It is emphasized that, because of the small number ofstudies found to be available, no restrictions regarding sample size or type oftherapy were imposed (Figure 2).


Influence of periodontal therapy on C-reactive protein level: a systematic review and meta-analysis.

Freitas CO, Gomes-Filho IS, Naves RC, Nogueira Filho Gda R, Cruz SS, Santos CA, Dunningham L, Miranda LF, Barbosa MD - J Appl Oral Sci (2012)

Article selection and inclusion process
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928764&req=5

f02: Article selection and inclusion process
Mentions: All English-language articles dealing with the effects of periodontal therapy on theserum levels of C-reactive protein among humans were selected, independent of theperiodontal therapy applied. The selection was also made according to study design,searching for clinical trials. It is emphasized that, because of the small number ofstudies found to be available, no restrictions regarding sample size or type oftherapy were imposed (Figure 2).

Bottom Line: The influence of oral infections, especially periodontal disease, on systemic diseases has been extensively discussed in the literature.Because periodontal disease is a persistent infection, it promotes an inflammatory response.The result was statistically significant, without evidence of heterogeneity between the studies (p=0.311).

View Article: PubMed Central - PubMed

Affiliation: Bahia School of Medicine and Public Health, Salvador, BA, Brazil. camila.otf@gmail.com

ABSTRACT

Unlabelled: The influence of oral infections, especially periodontal disease, on systemic diseases has been extensively discussed in the literature. Because periodontal disease is a persistent infection, it promotes an inflammatory response. C-reactive protein is a marker for inflammatory reactions that is frequently studied, since elevated levels of this protein are related to coronary events.

Objective: The aim of this study was to investigate the effect of periodontal therapy on reducing the serum levels of C-reactive protein, by means of a systematic review of the literature and meta-analysis.

Material and methods: A systematic review of the English-language literature was conducted in the PUBMED-MEDLINE database, using the key words "periodontal disease", "C-reactive protein", "periodontal therapy" and "periodontal treatment", in accordance with the terms for Medical Subject Headings (MeSH), to evaluate the effect of periodontal therapy on C-reactive protein levels. A qualitative analysis of studies of randomized clinical trial design was performed using CONSORT, with subsequent meta-analysis.

Results: The literature search initially retrieved 46 potentially relevant studies available in the databases. From these, in accordance with the inclusion criteria, only 11 were selected, of which only 4 fulfilled the criteria of randomized clinical trial design. According to CONSORT, the studies evaluated generally presented good quality with regard to the criteria analyzed. Through meta-analysis, the reduction in mean levels of C-reactive protein (-0.231; p=0.000) after introducing periodontal treatment was estimated. The result was statistically significant, without evidence of heterogeneity between the studies (p=0.311).

Conclusions: The findings indicated that non-surgical periodontal treatment had a positive effect with regard to reduction of the serum levels of C-reactive protein.

Show MeSH
Related in: MedlinePlus