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Isolated cerebellar hypermetabolism on FDG PET in a case of remitted primary breast lymphoma.

Reddy AK, Santhosh S, Mittal BR, Bhattacharya A, Sharma SC - Indian J Nucl Med (2014)

Bottom Line: We present here a case of primary non-Hodgkin's lymphoma of the breast that succumbed in a sub-acute course to death after three months of initial remission.The fluorodeoxyglucose positron emission tomography imaging during the declining clinical status showed isolated cerebellar hypermetabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

ABSTRACT
We present here a case of primary non-Hodgkin's lymphoma of the breast that succumbed in a sub-acute course to death after three months of initial remission. The fluorodeoxyglucose positron emission tomography imaging during the declining clinical status showed isolated cerebellar hypermetabolism.

No MeSH data available.


Related in: MedlinePlus

PET/CT images (a) anterior and (b) left lateral maximum intensity projection images show hypermetabolic cerebellum with no abnormal FDG localization elsewhere. CT, PET and fused- PET/CT transaxial (c-e) and sagittal (f-h) images of the head show intense diffuse FDG-uptake in the cerebellum. The findings were suggestive of relapse of disease vs. paraneoplastic cerebellar degeneration
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Figure 1: PET/CT images (a) anterior and (b) left lateral maximum intensity projection images show hypermetabolic cerebellum with no abnormal FDG localization elsewhere. CT, PET and fused- PET/CT transaxial (c-e) and sagittal (f-h) images of the head show intense diffuse FDG-uptake in the cerebellum. The findings were suggestive of relapse of disease vs. paraneoplastic cerebellar degeneration

Mentions: A 50-year-old female patient presented with a palpable mass in the left breast for the last four months. Histologic and immunocytochemical analyses of biopsy tissue from the breast mass showed high grade-B cell non-Hodgkin's lymphoma (NHL). Pre-chemotherapy evaluation showed additional involvement of left axillary lymph nodes. Bone marrow evaluation for involvement of lymphoma was negative. The patient was subjected to six cycles of chemotherapy with CHOP regimen and a post-chemotherapy evaluation with contrast enhanced computed tomography (CECT) showed remission of disease. Three months following the initial remission, the patient presented with complaints of gait imbalance, dysarthria, headache, and vomiting. Suspecting a relapse with central nervous system (CNS) involvement, PET/CT imaging was performed. Figure 1 anterior (A) and left lateral (B) maximum intensity projection images show hypermetabolic cerebellum with no abnormal FDG localization elsewhere. CT, PET, and fused PET/CT images of the head in axial (C-E) and sagittal (F-H) views show intense diffuse FDG uptake in the cerebellum. The findings were suggestive of relapse of disease vs. paraneoplastic cerebellar degeneration. However, the patient's clinical status declined rapidly and died before further diagnostic workup.


Isolated cerebellar hypermetabolism on FDG PET in a case of remitted primary breast lymphoma.

Reddy AK, Santhosh S, Mittal BR, Bhattacharya A, Sharma SC - Indian J Nucl Med (2014)

PET/CT images (a) anterior and (b) left lateral maximum intensity projection images show hypermetabolic cerebellum with no abnormal FDG localization elsewhere. CT, PET and fused- PET/CT transaxial (c-e) and sagittal (f-h) images of the head show intense diffuse FDG-uptake in the cerebellum. The findings were suggestive of relapse of disease vs. paraneoplastic cerebellar degeneration
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928756&req=5

Figure 1: PET/CT images (a) anterior and (b) left lateral maximum intensity projection images show hypermetabolic cerebellum with no abnormal FDG localization elsewhere. CT, PET and fused- PET/CT transaxial (c-e) and sagittal (f-h) images of the head show intense diffuse FDG-uptake in the cerebellum. The findings were suggestive of relapse of disease vs. paraneoplastic cerebellar degeneration
Mentions: A 50-year-old female patient presented with a palpable mass in the left breast for the last four months. Histologic and immunocytochemical analyses of biopsy tissue from the breast mass showed high grade-B cell non-Hodgkin's lymphoma (NHL). Pre-chemotherapy evaluation showed additional involvement of left axillary lymph nodes. Bone marrow evaluation for involvement of lymphoma was negative. The patient was subjected to six cycles of chemotherapy with CHOP regimen and a post-chemotherapy evaluation with contrast enhanced computed tomography (CECT) showed remission of disease. Three months following the initial remission, the patient presented with complaints of gait imbalance, dysarthria, headache, and vomiting. Suspecting a relapse with central nervous system (CNS) involvement, PET/CT imaging was performed. Figure 1 anterior (A) and left lateral (B) maximum intensity projection images show hypermetabolic cerebellum with no abnormal FDG localization elsewhere. CT, PET, and fused PET/CT images of the head in axial (C-E) and sagittal (F-H) views show intense diffuse FDG uptake in the cerebellum. The findings were suggestive of relapse of disease vs. paraneoplastic cerebellar degeneration. However, the patient's clinical status declined rapidly and died before further diagnostic workup.

Bottom Line: We present here a case of primary non-Hodgkin's lymphoma of the breast that succumbed in a sub-acute course to death after three months of initial remission.The fluorodeoxyglucose positron emission tomography imaging during the declining clinical status showed isolated cerebellar hypermetabolism.

View Article: PubMed Central - PubMed

Affiliation: Department of Nuclear Medicine and PET, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

ABSTRACT
We present here a case of primary non-Hodgkin's lymphoma of the breast that succumbed in a sub-acute course to death after three months of initial remission. The fluorodeoxyglucose positron emission tomography imaging during the declining clinical status showed isolated cerebellar hypermetabolism.

No MeSH data available.


Related in: MedlinePlus