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Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads of Pectin and Modified Xanthan Gum.

Giri TK, Choudhary C, Alexander A - Indian J Pharm Sci (2013)

Bottom Line: Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride.The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices.The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

View Article: PubMed Central - PubMed

Affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.

ABSTRACT
Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise the hydrogel beads. The swelling of the hydrogel and the release of drug were relatively low in pH 1.2 buffer solutions. However, higher swelling and drug release were observed in pH 6.8 buffer solutions. The carboxyl functional groups of hydrogels undergo ionisation and the osmotic pressure inside the beads increases resulting in higher swelling and drug release in higher pH. The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices. The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

No MeSH data available.


Related in: MedlinePlus

Biodegradation patter of hydrogel beads.Biodegradation study of DTZ in lysozyme solution prepared using different concentration of GA and without GA. Biodegradation patterns of F1 (●); F9 (■); F10 (Δ); F11 (▲); and F12 (×).
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Figure 5: Biodegradation patter of hydrogel beads.Biodegradation study of DTZ in lysozyme solution prepared using different concentration of GA and without GA. Biodegradation patterns of F1 (●); F9 (■); F10 (Δ); F11 (▲); and F12 (×).

Mentions: An in vitro biodegradation study of the prepared beads was carried out in presence of lysozyme. The percent of remaining weight of bead was determined as a function of time and considered as a measure of degradation. Fig. 5 shows the degradation patterns of the beads prepared using GA as a cross-linking agent in addition to the control formulation prepared without GA. The IPN beads prepared without GA showed higher extent of degradation (lower percent remaining weights) than the beads prepared with GA (fig. 5). The beads prepared using GA showed less swelling than the beads prepared using without GA (Table 2). This decrease in swelling hinders the diffusion of enzyme through the hydrogel matrix and consequently decreases the rate of degradation. Further, it was observed that increasing the GA content in the IPN beads decreased their degradation rate. This is due to the increase of cross-linking density upon increasing the GA content, which tends to impede the diffusion of enzyme through the beads and consequently retards their degradation.


Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads of Pectin and Modified Xanthan Gum.

Giri TK, Choudhary C, Alexander A - Indian J Pharm Sci (2013)

Biodegradation patter of hydrogel beads.Biodegradation study of DTZ in lysozyme solution prepared using different concentration of GA and without GA. Biodegradation patterns of F1 (●); F9 (■); F10 (Δ); F11 (▲); and F12 (×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928724&req=5

Figure 5: Biodegradation patter of hydrogel beads.Biodegradation study of DTZ in lysozyme solution prepared using different concentration of GA and without GA. Biodegradation patterns of F1 (●); F9 (■); F10 (Δ); F11 (▲); and F12 (×).
Mentions: An in vitro biodegradation study of the prepared beads was carried out in presence of lysozyme. The percent of remaining weight of bead was determined as a function of time and considered as a measure of degradation. Fig. 5 shows the degradation patterns of the beads prepared using GA as a cross-linking agent in addition to the control formulation prepared without GA. The IPN beads prepared without GA showed higher extent of degradation (lower percent remaining weights) than the beads prepared with GA (fig. 5). The beads prepared using GA showed less swelling than the beads prepared using without GA (Table 2). This decrease in swelling hinders the diffusion of enzyme through the hydrogel matrix and consequently decreases the rate of degradation. Further, it was observed that increasing the GA content in the IPN beads decreased their degradation rate. This is due to the increase of cross-linking density upon increasing the GA content, which tends to impede the diffusion of enzyme through the beads and consequently retards their degradation.

Bottom Line: Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride.The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices.The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

View Article: PubMed Central - PubMed

Affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.

ABSTRACT
Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise the hydrogel beads. The swelling of the hydrogel and the release of drug were relatively low in pH 1.2 buffer solutions. However, higher swelling and drug release were observed in pH 6.8 buffer solutions. The carboxyl functional groups of hydrogels undergo ionisation and the osmotic pressure inside the beads increases resulting in higher swelling and drug release in higher pH. The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices. The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

No MeSH data available.


Related in: MedlinePlus