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Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads of Pectin and Modified Xanthan Gum.

Giri TK, Choudhary C, Alexander A - Indian J Pharm Sci (2013)

Bottom Line: Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride.The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices.The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

View Article: PubMed Central - PubMed

Affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.

ABSTRACT
Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise the hydrogel beads. The swelling of the hydrogel and the release of drug were relatively low in pH 1.2 buffer solutions. However, higher swelling and drug release were observed in pH 6.8 buffer solutions. The carboxyl functional groups of hydrogels undergo ionisation and the osmotic pressure inside the beads increases resulting in higher swelling and drug release in higher pH. The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices. The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

No MeSH data available.


Related in: MedlinePlus

Comparative X-ray diffractograms.X-ray diffractograms of DTZ (a), drug free IPN bead (b), and drug-loaded IPN bead (c).
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Figure 3: Comparative X-ray diffractograms.X-ray diffractograms of DTZ (a), drug free IPN bead (b), and drug-loaded IPN bead (c).

Mentions: X-ray diffractograms of DTZ, drug free bead and drug-loaded bead are presented in fig. 3. DTZ has shown characteristic intense peaks between 0° and 60° (2θ) due to its crystalline nature. No intense peaks were observed between 0° and 60° (2θ) in both drug free and drug-loaded hydrogel beads. The diffractograms of both drug free and drug-loaded beads are almost identical, indicating the amorphous dispersion of the drug after entrapment into the hydrogel beads.


Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads of Pectin and Modified Xanthan Gum.

Giri TK, Choudhary C, Alexander A - Indian J Pharm Sci (2013)

Comparative X-ray diffractograms.X-ray diffractograms of DTZ (a), drug free IPN bead (b), and drug-loaded IPN bead (c).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928724&req=5

Figure 3: Comparative X-ray diffractograms.X-ray diffractograms of DTZ (a), drug free IPN bead (b), and drug-loaded IPN bead (c).
Mentions: X-ray diffractograms of DTZ, drug free bead and drug-loaded bead are presented in fig. 3. DTZ has shown characteristic intense peaks between 0° and 60° (2θ) due to its crystalline nature. No intense peaks were observed between 0° and 60° (2θ) in both drug free and drug-loaded hydrogel beads. The diffractograms of both drug free and drug-loaded beads are almost identical, indicating the amorphous dispersion of the drug after entrapment into the hydrogel beads.

Bottom Line: Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride.The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices.The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

View Article: PubMed Central - PubMed

Affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.

ABSTRACT
Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise the hydrogel beads. The swelling of the hydrogel and the release of drug were relatively low in pH 1.2 buffer solutions. However, higher swelling and drug release were observed in pH 6.8 buffer solutions. The carboxyl functional groups of hydrogels undergo ionisation and the osmotic pressure inside the beads increases resulting in higher swelling and drug release in higher pH. The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices. The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

No MeSH data available.


Related in: MedlinePlus