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Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads of Pectin and Modified Xanthan Gum.

Giri TK, Choudhary C, Alexander A - Indian J Pharm Sci (2013)

Bottom Line: Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride.The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices.The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

View Article: PubMed Central - PubMed

Affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.

ABSTRACT
Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise the hydrogel beads. The swelling of the hydrogel and the release of drug were relatively low in pH 1.2 buffer solutions. However, higher swelling and drug release were observed in pH 6.8 buffer solutions. The carboxyl functional groups of hydrogels undergo ionisation and the osmotic pressure inside the beads increases resulting in higher swelling and drug release in higher pH. The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices. The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

No MeSH data available.


Related in: MedlinePlus

Comparative DSC thermograms.DSC thermograms of (a) DTZ, (b) Drug free IPN beads and (c) Drug loaded IPN beads.
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Figure 2: Comparative DSC thermograms.DSC thermograms of (a) DTZ, (b) Drug free IPN beads and (c) Drug loaded IPN beads.

Mentions: DSC thermograms of DTZ, drug free bead and drug-loaded beads are shown in fig. 2. A sharp endothermic peak corresponding to the melting point of DTZ is found at 218.65° (fig. 2a). The DSC thermogram of drug free bead (fig. 2b) exhibits a broad endothermic peak at 97.5°. However, drug-loaded bead (fig. 2c) does not show sharp endothermic peak; instead a broad endothermic peak at 98.42°. The disappearance of the melting endothermic peak of the drug indicates that the drug might have been molecularly dispersed or converted into amorphous form during the preparation of IPN bead.[2930].


Sustained Release of Diltiazem Hydrochloride from Cross-linked Biodegradable IPN Hydrogel Beads of Pectin and Modified Xanthan Gum.

Giri TK, Choudhary C, Alexander A - Indian J Pharm Sci (2013)

Comparative DSC thermograms.DSC thermograms of (a) DTZ, (b) Drug free IPN beads and (c) Drug loaded IPN beads.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928724&req=5

Figure 2: Comparative DSC thermograms.DSC thermograms of (a) DTZ, (b) Drug free IPN beads and (c) Drug loaded IPN beads.
Mentions: DSC thermograms of DTZ, drug free bead and drug-loaded beads are shown in fig. 2. A sharp endothermic peak corresponding to the melting point of DTZ is found at 218.65° (fig. 2a). The DSC thermogram of drug free bead (fig. 2b) exhibits a broad endothermic peak at 97.5°. However, drug-loaded bead (fig. 2c) does not show sharp endothermic peak; instead a broad endothermic peak at 98.42°. The disappearance of the melting endothermic peak of the drug indicates that the drug might have been molecularly dispersed or converted into amorphous form during the preparation of IPN bead.[2930].

Bottom Line: Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride.The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices.The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

View Article: PubMed Central - PubMed

Affiliation: Rungta College of Pharmaceutical Sciences and Research, Kohka Road, Kurud, Bhilai-491 024, India.

ABSTRACT
Interpenetrating polymer network hydrogel beads of pectin and sodium carboxymethyl xanthan were prepared by ionotropic gelation with Al(+3) ions and covalent cross-linking with glutaraldehyde for sustained delivery of diltiazem hydrochloride. Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning colorimetry and scanning electron microscopy were used to characterise the hydrogel beads. The swelling of the hydrogel and the release of drug were relatively low in pH 1.2 buffer solutions. However, higher swelling and drug release were observed in pH 6.8 buffer solutions. The carboxyl functional groups of hydrogels undergo ionisation and the osmotic pressure inside the beads increases resulting in higher swelling and drug release in higher pH. The release of drug depends on concentration of polymer, amount and exposure time of cross-linker and drug content in the hydrogel matrices. The present study indicated that the hydrogel beads minimised the drug release in pH 1.2 buffer solutions and to prolong the drug release in pH 6.8 buffer solutions.

No MeSH data available.


Related in: MedlinePlus