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CiteAb: a searchable antibody database that ranks antibodies by the number of times they have been cited.

Helsby MA, Leader PM, Fenn JR, Gulsen T, Bryant C, Doughton G, Sharpe B, Whitley P, Caunt CJ, James K, Pope AD, Kelly DH, Chalmers AD - BMC Cell Biol. (2014)

Bottom Line: A well accepted way of selecting a research antibody is to identify one which has been used previously, where the associated data has been peer-reviewed and the results published.CiteAb provides a new way for researchers to find research antibodies that have been used successfully in peer-reviewed publications.It aims to assist these researchers and will hopefully help promote progress in many areas of life science research.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK. ac270@bath.ac.uk.

ABSTRACT

Background: Research antibodies are used by thousands of scientists working in diverse disciplines, but it is common to hear concerns about antibody quality. This means that researchers need to carefully choose the antibodies they use to avoid wasting time and money. A well accepted way of selecting a research antibody is to identify one which has been used previously, where the associated data has been peer-reviewed and the results published.

Description: CiteAb is a searchable database which ranks antibodies by the number of times they have been cited. This allows researchers to easily find antibodies that have been used in peer-reviewed publications and the accompanying citations are listed, so users can check the data contained within the publications. This makes CiteAb a useful resource for identifying antibodies for experiments and also for finding information to demonstrate antibody validation. The database currently contains 1,400,000 antibodies which are from 90 suppliers, including 87 commercial companies and 3 academic resources. Associated with these antibodies are 140,000 publications which provide 306,000 antibody citations. In addition to searching, users can also browse through the antibodies and add their own publications to the CiteAb database.

Conclusions: CiteAb provides a new way for researchers to find research antibodies that have been used successfully in peer-reviewed publications. It aims to assist these researchers and will hopefully help promote progress in many areas of life science research.

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Related in: MedlinePlus

Example of a CiteAb antibody page. Each antibody page provides details of the antibody code, antibody name, name of the supplier, host species, whether the antibody is polyclonal or monoclonal, clone number if monoclonal (not present in this example), any conjugated moiety such as FITC (not present in this example), synonyms for the antigen (not present in this example) and information on the immunogen. Published reactivity, published applications, supplier recommended reactivity and supplier recommended applications are also provided where available. Not all antibodies will have complete information as several of these data fields have been added recently and uploading of the additional information is continuing. The antibody page also lists publications that have cited the antibody. The first ten are shown automatically, with an option to view the remainder. Each publication has a link to a corresponding ‘publication page’ (Figure 3). There are also links to add a publication, report a problem and sign up to the CiteAb newsletter.
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Related In: Results  -  Collection

License 1 - License 2
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Figure 2: Example of a CiteAb antibody page. Each antibody page provides details of the antibody code, antibody name, name of the supplier, host species, whether the antibody is polyclonal or monoclonal, clone number if monoclonal (not present in this example), any conjugated moiety such as FITC (not present in this example), synonyms for the antigen (not present in this example) and information on the immunogen. Published reactivity, published applications, supplier recommended reactivity and supplier recommended applications are also provided where available. Not all antibodies will have complete information as several of these data fields have been added recently and uploading of the additional information is continuing. The antibody page also lists publications that have cited the antibody. The first ten are shown automatically, with an option to view the remainder. Each publication has a link to a corresponding ‘publication page’ (Figure 3). There are also links to add a publication, report a problem and sign up to the CiteAb newsletter.

Mentions: Having identified an antibody of interest, users are then able to navigate to the ‘antibody page’ (Figure 2) by clicking on the relevant row for the antibody. An antibody page displays the antibody code, antibody name, name of the supplier, host species, published applications and published species reactivity. A recent upgrade of the database has added fields for the following; whether the antibody is polyclonal or monoclonal, clone number if monoclonal, any conjugated moiety such as Fluorescein isothiocyanate (FITC), synonyms for the target protein and information on the immunogen. These fields are only displayed if the information is present in the database, for the example shown in Figure 2 fields for synonym, clone number and conjugated moiety are not displayed. Fields for supplier recommended applications and supplier recommended species reactivity have also recently been added. Uploading of information for the new fields is ongoing, so not all antibodies will have this additional information. If the antibody appears worthy of further investigation the user can follow links to the corresponding antibody page on the supplier website for further information.


CiteAb: a searchable antibody database that ranks antibodies by the number of times they have been cited.

Helsby MA, Leader PM, Fenn JR, Gulsen T, Bryant C, Doughton G, Sharpe B, Whitley P, Caunt CJ, James K, Pope AD, Kelly DH, Chalmers AD - BMC Cell Biol. (2014)

Example of a CiteAb antibody page. Each antibody page provides details of the antibody code, antibody name, name of the supplier, host species, whether the antibody is polyclonal or monoclonal, clone number if monoclonal (not present in this example), any conjugated moiety such as FITC (not present in this example), synonyms for the antigen (not present in this example) and information on the immunogen. Published reactivity, published applications, supplier recommended reactivity and supplier recommended applications are also provided where available. Not all antibodies will have complete information as several of these data fields have been added recently and uploading of the additional information is continuing. The antibody page also lists publications that have cited the antibody. The first ten are shown automatically, with an option to view the remainder. Each publication has a link to a corresponding ‘publication page’ (Figure 3). There are also links to add a publication, report a problem and sign up to the CiteAb newsletter.
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3928599&req=5

Figure 2: Example of a CiteAb antibody page. Each antibody page provides details of the antibody code, antibody name, name of the supplier, host species, whether the antibody is polyclonal or monoclonal, clone number if monoclonal (not present in this example), any conjugated moiety such as FITC (not present in this example), synonyms for the antigen (not present in this example) and information on the immunogen. Published reactivity, published applications, supplier recommended reactivity and supplier recommended applications are also provided where available. Not all antibodies will have complete information as several of these data fields have been added recently and uploading of the additional information is continuing. The antibody page also lists publications that have cited the antibody. The first ten are shown automatically, with an option to view the remainder. Each publication has a link to a corresponding ‘publication page’ (Figure 3). There are also links to add a publication, report a problem and sign up to the CiteAb newsletter.
Mentions: Having identified an antibody of interest, users are then able to navigate to the ‘antibody page’ (Figure 2) by clicking on the relevant row for the antibody. An antibody page displays the antibody code, antibody name, name of the supplier, host species, published applications and published species reactivity. A recent upgrade of the database has added fields for the following; whether the antibody is polyclonal or monoclonal, clone number if monoclonal, any conjugated moiety such as Fluorescein isothiocyanate (FITC), synonyms for the target protein and information on the immunogen. These fields are only displayed if the information is present in the database, for the example shown in Figure 2 fields for synonym, clone number and conjugated moiety are not displayed. Fields for supplier recommended applications and supplier recommended species reactivity have also recently been added. Uploading of information for the new fields is ongoing, so not all antibodies will have this additional information. If the antibody appears worthy of further investigation the user can follow links to the corresponding antibody page on the supplier website for further information.

Bottom Line: A well accepted way of selecting a research antibody is to identify one which has been used previously, where the associated data has been peer-reviewed and the results published.CiteAb provides a new way for researchers to find research antibodies that have been used successfully in peer-reviewed publications.It aims to assist these researchers and will hopefully help promote progress in many areas of life science research.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK. ac270@bath.ac.uk.

ABSTRACT

Background: Research antibodies are used by thousands of scientists working in diverse disciplines, but it is common to hear concerns about antibody quality. This means that researchers need to carefully choose the antibodies they use to avoid wasting time and money. A well accepted way of selecting a research antibody is to identify one which has been used previously, where the associated data has been peer-reviewed and the results published.

Description: CiteAb is a searchable database which ranks antibodies by the number of times they have been cited. This allows researchers to easily find antibodies that have been used in peer-reviewed publications and the accompanying citations are listed, so users can check the data contained within the publications. This makes CiteAb a useful resource for identifying antibodies for experiments and also for finding information to demonstrate antibody validation. The database currently contains 1,400,000 antibodies which are from 90 suppliers, including 87 commercial companies and 3 academic resources. Associated with these antibodies are 140,000 publications which provide 306,000 antibody citations. In addition to searching, users can also browse through the antibodies and add their own publications to the CiteAb database.

Conclusions: CiteAb provides a new way for researchers to find research antibodies that have been used successfully in peer-reviewed publications. It aims to assist these researchers and will hopefully help promote progress in many areas of life science research.

Show MeSH
Related in: MedlinePlus