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Assessment of morbidity due to Schistosoma japonicum infection in China.

Chen MG - Infect Dis Poverty (2014)

Bottom Line: Due to the socio-economic situation, which did not allow for a control program to be implemented until the early 1950s, morbidity was serious and mortality was high before this.Comparatively higher morbidity is seen in the acute and advanced phases of the disease.The problem of mammalian reservoir hosts of S. japonicum makes the epidemiology and control of schistosomiasis in China even more complicated and arduous, and the control progress in animal reservoirs is briefly presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People's Republic of China. mgchen51@hotmail.com.

ABSTRACT
This paper presents a historical assessment of morbidity due to the Schistosoma japonicum infection in China. Due to the socio-economic situation, which did not allow for a control program to be implemented until the early 1950s, morbidity was serious and mortality was high before this. Based on a few investigations and published papers, it can be said that the disease caused millions of deaths, and destroyed numerous families and villages. Since the 1950s, there has been a national control program, intensive control and prevention work has been carried out, and consequently the disease is being controlled. At present, both the prevalence and the morbidity of the disease have been decreasing substantially. The morbidity of the three phases of the disease is outlined in this paper. Comparatively higher morbidity is seen in the acute and advanced phases of the disease. The four major forms of advanced schistosomiasis i.e., ascites, megalosplenia, dwarfism, and colonic tumoroid proliferation, are outlined with their characteristic clinical presentations; their proportions are different during various periods of the national control program. Ectopic schistosomiasis and the relationship between the S. japonicum infection and colorectal cancer are also discussed. Post-transmission schistosomiasis is briefly discussed (which can happen even if the disease reaches the criteria of elimination, and the infection and transmission have stopped, but yet it still develops). The problem of mammalian reservoir hosts of S. japonicum makes the epidemiology and control of schistosomiasis in China even more complicated and arduous, and the control progress in animal reservoirs is briefly presented.

No MeSH data available.


Related in: MedlinePlus

Dilatation of abdominal collateral veins due to portal hypertension in a patient with advanced schistosomiasis. The enlarged spleen was marked with black ink. (Author’s collection).
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Figure 11: Dilatation of abdominal collateral veins due to portal hypertension in a patient with advanced schistosomiasis. The enlarged spleen was marked with black ink. (Author’s collection).

Mentions: Advanced schistosomiasis with ascites and/or megalosplenia is usually associated with abdominal collateral vein dilation (see Figure 11) and oesophagogastric varices. The rupture of varices occurs mostly at the fundus of the stomach and, secondarily, in the lower third of the oesophagus. Haematemesis and melaena are frequent, and upper gastrointestinal bleeding is the most important cause of death (above 50%) in advanced schistosomiasis. The second important cause of death is hepatic failure with or without going into a hepatic coma [48].


Assessment of morbidity due to Schistosoma japonicum infection in China.

Chen MG - Infect Dis Poverty (2014)

Dilatation of abdominal collateral veins due to portal hypertension in a patient with advanced schistosomiasis. The enlarged spleen was marked with black ink. (Author’s collection).
© Copyright Policy - open-access
Related In: Results  -  Collection

License 1 - License 2
Show All Figures
getmorefigures.php?uid=PMC3928580&req=5

Figure 11: Dilatation of abdominal collateral veins due to portal hypertension in a patient with advanced schistosomiasis. The enlarged spleen was marked with black ink. (Author’s collection).
Mentions: Advanced schistosomiasis with ascites and/or megalosplenia is usually associated with abdominal collateral vein dilation (see Figure 11) and oesophagogastric varices. The rupture of varices occurs mostly at the fundus of the stomach and, secondarily, in the lower third of the oesophagus. Haematemesis and melaena are frequent, and upper gastrointestinal bleeding is the most important cause of death (above 50%) in advanced schistosomiasis. The second important cause of death is hepatic failure with or without going into a hepatic coma [48].

Bottom Line: Due to the socio-economic situation, which did not allow for a control program to be implemented until the early 1950s, morbidity was serious and mortality was high before this.Comparatively higher morbidity is seen in the acute and advanced phases of the disease.The problem of mammalian reservoir hosts of S. japonicum makes the epidemiology and control of schistosomiasis in China even more complicated and arduous, and the control progress in animal reservoirs is briefly presented.

View Article: PubMed Central - HTML - PubMed

Affiliation: National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai, People's Republic of China. mgchen51@hotmail.com.

ABSTRACT
This paper presents a historical assessment of morbidity due to the Schistosoma japonicum infection in China. Due to the socio-economic situation, which did not allow for a control program to be implemented until the early 1950s, morbidity was serious and mortality was high before this. Based on a few investigations and published papers, it can be said that the disease caused millions of deaths, and destroyed numerous families and villages. Since the 1950s, there has been a national control program, intensive control and prevention work has been carried out, and consequently the disease is being controlled. At present, both the prevalence and the morbidity of the disease have been decreasing substantially. The morbidity of the three phases of the disease is outlined in this paper. Comparatively higher morbidity is seen in the acute and advanced phases of the disease. The four major forms of advanced schistosomiasis i.e., ascites, megalosplenia, dwarfism, and colonic tumoroid proliferation, are outlined with their characteristic clinical presentations; their proportions are different during various periods of the national control program. Ectopic schistosomiasis and the relationship between the S. japonicum infection and colorectal cancer are also discussed. Post-transmission schistosomiasis is briefly discussed (which can happen even if the disease reaches the criteria of elimination, and the infection and transmission have stopped, but yet it still develops). The problem of mammalian reservoir hosts of S. japonicum makes the epidemiology and control of schistosomiasis in China even more complicated and arduous, and the control progress in animal reservoirs is briefly presented.

No MeSH data available.


Related in: MedlinePlus