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Coordination of kidney organogenesis by Wnt signaling.

Halt K, Vainio S - Pediatr. Nephrol. (2014)

Bottom Line: The signal-transduction mechanisms of the Wnts in kidney ontogeny have not been resolved, but studies characterizing the downstream signaling pathways are emerging.Aberrant Wnt signaling may lead to kidney diseases ranging from fatal kidney agenesis to more benign phenotypes.Wnt-mediated signaling regulates several critical aspects of kidney development from the early inductive stages to later steps of tubular epithelial maturation.

View Article: PubMed Central - PubMed

Affiliation: The Centre of Excellence in Cell-Extracellular Matrix Research, Oulu, Finland.

ABSTRACT
Several Wnt proteins are expressed in the embryonic kidney during various stages of development. Gene knockout models and ex vivo studies have provided strong evidence that Wnt-mediated signals are essential in renal ontogeny. Perhaps the most critical factors, Wnt9b and Wnt4, function during the early phase when the cap mesenchyme is induced to undergo morphogenesis into a nephron. Wnt11 controls early ureteric bud branching and contributes to the final kidney size. In addition to its inductive role, later on Wnt9b plays a significant role in the convergent extension of the tubular epithelial cells, while Wnt4 signaling controls smooth muscle cell fates in the medulla. Wnt7b has a specific function together with its likely antagonist Dkk1 in controlling the morphogenesis of the renal medulla. The signal-transduction mechanisms of the Wnts in kidney ontogeny have not been resolved, but studies characterizing the downstream signaling pathways are emerging. Aberrant Wnt signaling may lead to kidney diseases ranging from fatal kidney agenesis to more benign phenotypes. Wnt-mediated signaling regulates several critical aspects of kidney development from the early inductive stages to later steps of tubular epithelial maturation.

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Nephron morphogenesis. As a consequence of mesenchyme-to-epithelium transition, a lumen containing renal vesicle (a) is assembled from the pre-tubular aggregate. A cleft forms within the epithelium of the renal vesicle turning it into a comma-shaped body (b). After another cleft formation step in the distal comma-shaped body an S-shaped body stage emerges (c). The distal part of the S-shaped body connects with the ureteric bud (UB)-derived collecting duct system while the proximal part forms the Bowman’s capsule
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Fig2: Nephron morphogenesis. As a consequence of mesenchyme-to-epithelium transition, a lumen containing renal vesicle (a) is assembled from the pre-tubular aggregate. A cleft forms within the epithelium of the renal vesicle turning it into a comma-shaped body (b). After another cleft formation step in the distal comma-shaped body an S-shaped body stage emerges (c). The distal part of the S-shaped body connects with the ureteric bud (UB)-derived collecting duct system while the proximal part forms the Bowman’s capsule

Mentions: The renal vesicle matures into a functional nephron through comma- and S-shaped body stages (Fig. 2). The primordial nephron becomes elongated along the corticomedullary axis and forms morphologically distinguishable segments containing a Bowman’s capsule, a proximal convoluted tube, a loop of Henle, a distal convoluted tube, and a connecting tube. At the vascular pole, the nephron connects to the glomerular tuft composed of endothelial and mesangial cells, whereas the distal part joins with the collecting duct.Fig. 2


Coordination of kidney organogenesis by Wnt signaling.

Halt K, Vainio S - Pediatr. Nephrol. (2014)

Nephron morphogenesis. As a consequence of mesenchyme-to-epithelium transition, a lumen containing renal vesicle (a) is assembled from the pre-tubular aggregate. A cleft forms within the epithelium of the renal vesicle turning it into a comma-shaped body (b). After another cleft formation step in the distal comma-shaped body an S-shaped body stage emerges (c). The distal part of the S-shaped body connects with the ureteric bud (UB)-derived collecting duct system while the proximal part forms the Bowman’s capsule
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3928513&req=5

Fig2: Nephron morphogenesis. As a consequence of mesenchyme-to-epithelium transition, a lumen containing renal vesicle (a) is assembled from the pre-tubular aggregate. A cleft forms within the epithelium of the renal vesicle turning it into a comma-shaped body (b). After another cleft formation step in the distal comma-shaped body an S-shaped body stage emerges (c). The distal part of the S-shaped body connects with the ureteric bud (UB)-derived collecting duct system while the proximal part forms the Bowman’s capsule
Mentions: The renal vesicle matures into a functional nephron through comma- and S-shaped body stages (Fig. 2). The primordial nephron becomes elongated along the corticomedullary axis and forms morphologically distinguishable segments containing a Bowman’s capsule, a proximal convoluted tube, a loop of Henle, a distal convoluted tube, and a connecting tube. At the vascular pole, the nephron connects to the glomerular tuft composed of endothelial and mesangial cells, whereas the distal part joins with the collecting duct.Fig. 2

Bottom Line: The signal-transduction mechanisms of the Wnts in kidney ontogeny have not been resolved, but studies characterizing the downstream signaling pathways are emerging.Aberrant Wnt signaling may lead to kidney diseases ranging from fatal kidney agenesis to more benign phenotypes.Wnt-mediated signaling regulates several critical aspects of kidney development from the early inductive stages to later steps of tubular epithelial maturation.

View Article: PubMed Central - PubMed

Affiliation: The Centre of Excellence in Cell-Extracellular Matrix Research, Oulu, Finland.

ABSTRACT
Several Wnt proteins are expressed in the embryonic kidney during various stages of development. Gene knockout models and ex vivo studies have provided strong evidence that Wnt-mediated signals are essential in renal ontogeny. Perhaps the most critical factors, Wnt9b and Wnt4, function during the early phase when the cap mesenchyme is induced to undergo morphogenesis into a nephron. Wnt11 controls early ureteric bud branching and contributes to the final kidney size. In addition to its inductive role, later on Wnt9b plays a significant role in the convergent extension of the tubular epithelial cells, while Wnt4 signaling controls smooth muscle cell fates in the medulla. Wnt7b has a specific function together with its likely antagonist Dkk1 in controlling the morphogenesis of the renal medulla. The signal-transduction mechanisms of the Wnts in kidney ontogeny have not been resolved, but studies characterizing the downstream signaling pathways are emerging. Aberrant Wnt signaling may lead to kidney diseases ranging from fatal kidney agenesis to more benign phenotypes. Wnt-mediated signaling regulates several critical aspects of kidney development from the early inductive stages to later steps of tubular epithelial maturation.

Show MeSH
Related in: MedlinePlus