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Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin.

Bernd A - Phytochem Rev (2013)

Bottom Line: The therapeutic benefit is hampered by a very low absorption after trans-dermal or oral application.Therefore, great efforts were undertaken to enhance the effectiveness of curcumin.Recently, it was demonstrated that curcumin offers the described effects also at low concentrations (0.2-1 μg/ml) when applied in combination with UVA or visible light.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

ABSTRACT
Curcumin, a dietary pigment from the plant Curcuma longa, inhibits cell proliferation and induces apoptosis in different cell lines. The therapeutic benefit is hampered by a very low absorption after trans-dermal or oral application. Therefore, great efforts were undertaken to enhance the effectiveness of curcumin. Recently, it was demonstrated that curcumin offers the described effects also at low concentrations (0.2-1 μg/ml) when applied in combination with UVA or visible light. The efficacy of this combination was shown in human epidermal keratinocytes and in a panel of other cell species in vitro as well as in a xenograft tumor model with A431 tumor cells injected subcutaneously in the flanks of NMRI nude mice in vivo. The treatment of keratinocytes with curcumin and light resulted in the inhibition of cell growth, and in the induction of apoptosis, whereas no toxic cell membrane damage was detectable. The treatment of tumor bearing nude mice with curcumin and visible light resulted in reduced tumor volumes, reduced proliferation rates, and the induction of apoptosis in the tumors. On the molecular level inhibition of extracellular regulated kinases 1/2 and epidermal growth factor receptor was observed which may aid to inhibition of proliferation and induction of apoptosis. This review covers the experiences of the new combination treatment of human tumors.

No MeSH data available.


Related in: MedlinePlus

Schematic diagram of curcumin/light affected pathways. Green arrows enhancement, red arrows inhibition
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Fig2: Schematic diagram of curcumin/light affected pathways. Green arrows enhancement, red arrows inhibition

Mentions: In vitro- and in vivo-experiments showed that very low concentration of curcumin is sufficient to induce anti-tumor effects if the treatment is combined with UVA or visible light irradiation. The used doses of visible light or UVA alone did not show any significant anti-tumor effects. Just the combination of light with curcumin induced the described anti-tumor activities. The influence of low curcumin concentrations combined with light on key factors of growth and apoptosis was shown in vivo and in vitro (Fig. 2). Consequently, the difficulty of the low bioavailability of curcumin can be compensated by a combination of curcumin with light treatment. The pre-clinic experiments argue for starting the development of clinical therapy concepts based on curcumin and light. Further investigations are necessary to elucidate the physico-chemical mechanism of light dependent curcumin effects.Fig. 2


Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin.

Bernd A - Phytochem Rev (2013)

Schematic diagram of curcumin/light affected pathways. Green arrows enhancement, red arrows inhibition
© Copyright Policy - OpenAccess
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3928504&req=5

Fig2: Schematic diagram of curcumin/light affected pathways. Green arrows enhancement, red arrows inhibition
Mentions: In vitro- and in vivo-experiments showed that very low concentration of curcumin is sufficient to induce anti-tumor effects if the treatment is combined with UVA or visible light irradiation. The used doses of visible light or UVA alone did not show any significant anti-tumor effects. Just the combination of light with curcumin induced the described anti-tumor activities. The influence of low curcumin concentrations combined with light on key factors of growth and apoptosis was shown in vivo and in vitro (Fig. 2). Consequently, the difficulty of the low bioavailability of curcumin can be compensated by a combination of curcumin with light treatment. The pre-clinic experiments argue for starting the development of clinical therapy concepts based on curcumin and light. Further investigations are necessary to elucidate the physico-chemical mechanism of light dependent curcumin effects.Fig. 2

Bottom Line: The therapeutic benefit is hampered by a very low absorption after trans-dermal or oral application.Therefore, great efforts were undertaken to enhance the effectiveness of curcumin.Recently, it was demonstrated that curcumin offers the described effects also at low concentrations (0.2-1 μg/ml) when applied in combination with UVA or visible light.

View Article: PubMed Central - PubMed

Affiliation: Clinic for Dermatology, Venereology and Allergology, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.

ABSTRACT
Curcumin, a dietary pigment from the plant Curcuma longa, inhibits cell proliferation and induces apoptosis in different cell lines. The therapeutic benefit is hampered by a very low absorption after trans-dermal or oral application. Therefore, great efforts were undertaken to enhance the effectiveness of curcumin. Recently, it was demonstrated that curcumin offers the described effects also at low concentrations (0.2-1 μg/ml) when applied in combination with UVA or visible light. The efficacy of this combination was shown in human epidermal keratinocytes and in a panel of other cell species in vitro as well as in a xenograft tumor model with A431 tumor cells injected subcutaneously in the flanks of NMRI nude mice in vivo. The treatment of keratinocytes with curcumin and light resulted in the inhibition of cell growth, and in the induction of apoptosis, whereas no toxic cell membrane damage was detectable. The treatment of tumor bearing nude mice with curcumin and visible light resulted in reduced tumor volumes, reduced proliferation rates, and the induction of apoptosis in the tumors. On the molecular level inhibition of extracellular regulated kinases 1/2 and epidermal growth factor receptor was observed which may aid to inhibition of proliferation and induction of apoptosis. This review covers the experiences of the new combination treatment of human tumors.

No MeSH data available.


Related in: MedlinePlus