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Histopathology in barrett esophagus and barrett esophagus-related dysplasia.

Grin A, Streutker CJ - Clin Endosc (2014)

Bottom Line: Pathologic specimens, both biopsies and endoscopic mucosal resections, for Barrett esophagus and Barrett-associated dysplasia and malignancy are common for pathologists in North America, and the incidence in South Asian countries seems to be increasing.Dysplasia and malignancy arising in intestinalized gastric-type mucosa raises issues in the interpretation of dysplasia and the evaluation of the depth of invasion of malignancies that are not seen in squamous dysplasia and squamous cell carcinoma.We review the North American approach to these lesions.

View Article: PubMed Central - PubMed

Affiliation: Division of Pathology, Department of Laboratory Medicine, The Li Ka Shing Knowledge Institute, St. Michael's Hospital, the University of Toronto Faculty of Medicine, Toronto, ON, Canada.

ABSTRACT
Pathologic specimens, both biopsies and endoscopic mucosal resections, for Barrett esophagus and Barrett-associated dysplasia and malignancy are common for pathologists in North America, and the incidence in South Asian countries seems to be increasing. Dysplasia and malignancy arising in intestinalized gastric-type mucosa raises issues in the interpretation of dysplasia and the evaluation of the depth of invasion of malignancies that are not seen in squamous dysplasia and squamous cell carcinoma. We review the North American approach to these lesions.

No MeSH data available.


Related in: MedlinePlus

Endoscopic mucosal resection specimen demonstrating duplication of the muscularis mucosae (A, H&E stain, ×16; B, Desmin immunohistochemistry, ×16).
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Figure 3: Endoscopic mucosal resection specimen demonstrating duplication of the muscularis mucosae (A, H&E stain, ×16; B, Desmin immunohistochemistry, ×16).

Mentions: Submucosal invasion is diagnosed when tumor invades through the MM (i.e., the true MM and not the duplicated muscle, as discussed below). Unlike intramucosal carcinoma, submucosal invasion is often accompanied by a desmoplastic reaction. In addition to desmoplasia, tumor adjacent to a large vessel (although not entirely specific) may also signal submucosal invasion (Fig. 2). In equivocal cases, immunohistochemistry for desmin, highlighting the muscle layers, can be useful in identifying the deep limits of the MM (Fig. 3). Distinguishing intramucosal from submucosal invasion is clinically important as the risk of lymph node (LN) metastasis greatly increases.


Histopathology in barrett esophagus and barrett esophagus-related dysplasia.

Grin A, Streutker CJ - Clin Endosc (2014)

Endoscopic mucosal resection specimen demonstrating duplication of the muscularis mucosae (A, H&E stain, ×16; B, Desmin immunohistochemistry, ×16).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928489&req=5

Figure 3: Endoscopic mucosal resection specimen demonstrating duplication of the muscularis mucosae (A, H&E stain, ×16; B, Desmin immunohistochemistry, ×16).
Mentions: Submucosal invasion is diagnosed when tumor invades through the MM (i.e., the true MM and not the duplicated muscle, as discussed below). Unlike intramucosal carcinoma, submucosal invasion is often accompanied by a desmoplastic reaction. In addition to desmoplasia, tumor adjacent to a large vessel (although not entirely specific) may also signal submucosal invasion (Fig. 2). In equivocal cases, immunohistochemistry for desmin, highlighting the muscle layers, can be useful in identifying the deep limits of the MM (Fig. 3). Distinguishing intramucosal from submucosal invasion is clinically important as the risk of lymph node (LN) metastasis greatly increases.

Bottom Line: Pathologic specimens, both biopsies and endoscopic mucosal resections, for Barrett esophagus and Barrett-associated dysplasia and malignancy are common for pathologists in North America, and the incidence in South Asian countries seems to be increasing.Dysplasia and malignancy arising in intestinalized gastric-type mucosa raises issues in the interpretation of dysplasia and the evaluation of the depth of invasion of malignancies that are not seen in squamous dysplasia and squamous cell carcinoma.We review the North American approach to these lesions.

View Article: PubMed Central - PubMed

Affiliation: Division of Pathology, Department of Laboratory Medicine, The Li Ka Shing Knowledge Institute, St. Michael's Hospital, the University of Toronto Faculty of Medicine, Toronto, ON, Canada.

ABSTRACT
Pathologic specimens, both biopsies and endoscopic mucosal resections, for Barrett esophagus and Barrett-associated dysplasia and malignancy are common for pathologists in North America, and the incidence in South Asian countries seems to be increasing. Dysplasia and malignancy arising in intestinalized gastric-type mucosa raises issues in the interpretation of dysplasia and the evaluation of the depth of invasion of malignancies that are not seen in squamous dysplasia and squamous cell carcinoma. We review the North American approach to these lesions.

No MeSH data available.


Related in: MedlinePlus