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Serum total cholesterol concentration and 10-year mortality in an 85-year-old population.

Takata Y, Ansai T, Soh I, Awano S, Nakamichi I, Akifusa S, Goto K, Yoshida A, Fujii H, Fujisawa R, Sonoki K - Clin Interv Aging (2014)

Bottom Line: With the Kaplan-Meier method, we found that both the high-TC and intermediate-TC participants survived longer than the low-TC participants.The men with high TC survived longer than those with low TC, but no corresponding difference was found for the women.Mortality decreased with the increases in both TC and LDL-C concentrations, after adjustment for various confounding factors.

View Article: PubMed Central - PubMed

Affiliation: Division of General Internal Medicine, School of Oral Health Science, Kyushu Dental College, Kitakyushu, Japan.

ABSTRACT
Little is known about the association between total cholesterol (TC) and all-cause mortality in the elderly (especially the very elderly). Here we examined the association between TC and all-cause mortality in 207 very elderly (85-year-old) participants. In 2003, we performed a baseline laboratory blood examination, and blood pressure (BP) and body mass index (BMI) measurements, and lifestyle questionnaires were completed by the participants. The participants were followed for the subsequent 10 years. As of 2013, of the 207 participants in 2003, 70 participants had survived, 120 individuals had died, and 17 were lost to follow up. The TC values were divided into high-TC (≥209 mg/dL), intermediate-TC (176-208 mg/dL), and low-TC (≤175 mg/dL) categories. With the Kaplan-Meier method, we found that both the high-TC and intermediate-TC participants survived longer than the low-TC participants. The men with high TC survived longer than those with low TC, but no corresponding difference was found for the women. A multivariate Cox proportional hazards regression model, with adjustment for gender, smoking, alcohol intake, history of stroke or heart disease, serum albumin concentration, BMI, and systolic BP, revealed that the total mortality in the low-TC group was 1.7-fold higher than that in the high-TC group. Mortality, adjusted for the same factors, decreased 0.9% with each 1 mg/dL increase in the serum TC concentration and decreased 0.8% with each 1 mg/dL increase in the serum (low-density lipoprotein) LDL-cholesterol (LDL-C) concentration. Our results indicate an association between lower serum TC concentrations and increased all-cause mortality in a community-dwelling, very elderly population. Mortality decreased with the increases in both TC and LDL-C concentrations, after adjustment for various confounding factors. These findings suggest that low TC and low LDL-C may be independent predictors of high mortality in the very elderly.

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Related in: MedlinePlus

Survival curves of the participants who survived during the 10-year follow-up period among the three total cholesterol (TC) groups: for all participants (A), for men (B), and for women (C).
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f1-cia-9-293: Survival curves of the participants who survived during the 10-year follow-up period among the three total cholesterol (TC) groups: for all participants (A), for men (B), and for women (C).

Mentions: Figure 1 shows the survival curves of the participants among the three TC groups who survived during the 10-year follow-up period. The average survival period was 85.3 months for all participants and was 97.6 months for the high-TC group, 86.5 months for the intermediate-TC group, and 71.2 months for the low-TC group. The high-TC group survived significantly longer than did the low-TC group (P=0.000), and the intermediate-TC group also survived significantly longer than the low-TC group (P=0.024), whereas no difference was found between the high-TC group and the intermediate-TC group. Among the men, the average survival period was 73.4 months for all men, 95.5 months for the high-TC group, 76.2 months for the intermediate-TC group, and 61.6 months for the low-TC group. The men with high serum TC concentrations survived longer than did those with low TC concentrations (P=0.004). There was no difference in survival period between the high-TC group and the intermediate-TC group or between the intermediate-TC group and the low-TC group. Among the women, the survival period was 94.9 months for all women, 98.3 months for the high-TC women, 96.8 months for the intermediate-TC women, and 85.7 months for the low-TC women. There was no difference in survival period among the female TC groups.


Serum total cholesterol concentration and 10-year mortality in an 85-year-old population.

Takata Y, Ansai T, Soh I, Awano S, Nakamichi I, Akifusa S, Goto K, Yoshida A, Fujii H, Fujisawa R, Sonoki K - Clin Interv Aging (2014)

Survival curves of the participants who survived during the 10-year follow-up period among the three total cholesterol (TC) groups: for all participants (A), for men (B), and for women (C).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928456&req=5

f1-cia-9-293: Survival curves of the participants who survived during the 10-year follow-up period among the three total cholesterol (TC) groups: for all participants (A), for men (B), and for women (C).
Mentions: Figure 1 shows the survival curves of the participants among the three TC groups who survived during the 10-year follow-up period. The average survival period was 85.3 months for all participants and was 97.6 months for the high-TC group, 86.5 months for the intermediate-TC group, and 71.2 months for the low-TC group. The high-TC group survived significantly longer than did the low-TC group (P=0.000), and the intermediate-TC group also survived significantly longer than the low-TC group (P=0.024), whereas no difference was found between the high-TC group and the intermediate-TC group. Among the men, the average survival period was 73.4 months for all men, 95.5 months for the high-TC group, 76.2 months for the intermediate-TC group, and 61.6 months for the low-TC group. The men with high serum TC concentrations survived longer than did those with low TC concentrations (P=0.004). There was no difference in survival period between the high-TC group and the intermediate-TC group or between the intermediate-TC group and the low-TC group. Among the women, the survival period was 94.9 months for all women, 98.3 months for the high-TC women, 96.8 months for the intermediate-TC women, and 85.7 months for the low-TC women. There was no difference in survival period among the female TC groups.

Bottom Line: With the Kaplan-Meier method, we found that both the high-TC and intermediate-TC participants survived longer than the low-TC participants.The men with high TC survived longer than those with low TC, but no corresponding difference was found for the women.Mortality decreased with the increases in both TC and LDL-C concentrations, after adjustment for various confounding factors.

View Article: PubMed Central - PubMed

Affiliation: Division of General Internal Medicine, School of Oral Health Science, Kyushu Dental College, Kitakyushu, Japan.

ABSTRACT
Little is known about the association between total cholesterol (TC) and all-cause mortality in the elderly (especially the very elderly). Here we examined the association between TC and all-cause mortality in 207 very elderly (85-year-old) participants. In 2003, we performed a baseline laboratory blood examination, and blood pressure (BP) and body mass index (BMI) measurements, and lifestyle questionnaires were completed by the participants. The participants were followed for the subsequent 10 years. As of 2013, of the 207 participants in 2003, 70 participants had survived, 120 individuals had died, and 17 were lost to follow up. The TC values were divided into high-TC (≥209 mg/dL), intermediate-TC (176-208 mg/dL), and low-TC (≤175 mg/dL) categories. With the Kaplan-Meier method, we found that both the high-TC and intermediate-TC participants survived longer than the low-TC participants. The men with high TC survived longer than those with low TC, but no corresponding difference was found for the women. A multivariate Cox proportional hazards regression model, with adjustment for gender, smoking, alcohol intake, history of stroke or heart disease, serum albumin concentration, BMI, and systolic BP, revealed that the total mortality in the low-TC group was 1.7-fold higher than that in the high-TC group. Mortality, adjusted for the same factors, decreased 0.9% with each 1 mg/dL increase in the serum TC concentration and decreased 0.8% with each 1 mg/dL increase in the serum (low-density lipoprotein) LDL-cholesterol (LDL-C) concentration. Our results indicate an association between lower serum TC concentrations and increased all-cause mortality in a community-dwelling, very elderly population. Mortality decreased with the increases in both TC and LDL-C concentrations, after adjustment for various confounding factors. These findings suggest that low TC and low LDL-C may be independent predictors of high mortality in the very elderly.

Show MeSH
Related in: MedlinePlus