Limits...
Two cystic cavernous angiomas after radiotherapy for atypical meningioma in adult woman : case report and literature review.

Ruggeri AG, Donnarumma P, Pichierri A, Delfini R - J Korean Neurosurg Soc (2014)

Bottom Line: Ten years later, at the age of 49, she consulted for progressive drug-resistant headache.MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole.Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome, Rome, Italy.

ABSTRACT
A correlation between radiation therapy and cavernoma has been suspected since 1994. Since then, only a few cases of radio-induced cavernomas have been reported in the literature (85 patients). Most of them were children, and the most frequent original tumour had been medulloblastoma. The authors report a case of two cystic cavernous angiomas after radiation therapy for atypical meningioma in adult woman. This is the first case of cavernous angioma after radiotherapy for low grade meningioma. A 39-year-old, Latin american woman was operated on for a frontal atypical meningioma with intradiploic component and adjuvant radiotherapy was delivered (6000 cGy local brain irradiation, fractionated over 6 weeks). Follow-up MR imaging showed no recurrences of the tumour and no other lesions. Ten years later, at the age of 49, she consulted for progressive drug-resistant headache. MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole. Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma. This is the first case of cavernous angioma after radiation therapy for atypical meningioma : it confirms the development of these lesions after standard radiation therapy also in patients previously affected by non-malignant tumours.

No MeSH data available.


Related in: MedlinePlus

Cystic cavernous angiomas. Axial gadolinium enhanced T1-weighted MRI.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3928347&req=5

Figure 3: Cystic cavernous angiomas. Axial gadolinium enhanced T1-weighted MRI.

Mentions: Nine years later, at the age of 48, follow-up MR imaging showed two new well defined areas, with cystic and necrotic components, at the surface of each frontal pole. The lesions appeared isointense-hypointense on T1-weighted sequences, with heterogeneous gadolinium enhancement, and hyperintense on T2-weighted. Clinical examination was normal. The following year, at the age of 49, she presented to the emergency unit of our department with drug-resistant headache. MR imaging showed that both lesions had grown. The largest one (5.5×3.6 cm), in the left frontal lobe, was a large gliotic bordered lobulated lesion, with a big cystic component, that extended from the frontal pole to the frontal horn of lateral ventricle. The right lesion (3.7×2.4 cm), with a smaller cystic component, was entirely within the right pole (Fig. 3, 4). Bilateral frontal craniotomy was performed to remove both the masses. The histopathological diagnosis was cavernous angioma (Fig. 5). The lesion was composed of hyalinized vascular channels, with different calibers. The vessels were thick and amuscular and the brain parenchyma interposed between the channels showed gliosis. The patient had not family history of cavernomas. After surgical removal, symptomatology completely remitted.


Two cystic cavernous angiomas after radiotherapy for atypical meningioma in adult woman : case report and literature review.

Ruggeri AG, Donnarumma P, Pichierri A, Delfini R - J Korean Neurosurg Soc (2014)

Cystic cavernous angiomas. Axial gadolinium enhanced T1-weighted MRI.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928347&req=5

Figure 3: Cystic cavernous angiomas. Axial gadolinium enhanced T1-weighted MRI.
Mentions: Nine years later, at the age of 48, follow-up MR imaging showed two new well defined areas, with cystic and necrotic components, at the surface of each frontal pole. The lesions appeared isointense-hypointense on T1-weighted sequences, with heterogeneous gadolinium enhancement, and hyperintense on T2-weighted. Clinical examination was normal. The following year, at the age of 49, she presented to the emergency unit of our department with drug-resistant headache. MR imaging showed that both lesions had grown. The largest one (5.5×3.6 cm), in the left frontal lobe, was a large gliotic bordered lobulated lesion, with a big cystic component, that extended from the frontal pole to the frontal horn of lateral ventricle. The right lesion (3.7×2.4 cm), with a smaller cystic component, was entirely within the right pole (Fig. 3, 4). Bilateral frontal craniotomy was performed to remove both the masses. The histopathological diagnosis was cavernous angioma (Fig. 5). The lesion was composed of hyalinized vascular channels, with different calibers. The vessels were thick and amuscular and the brain parenchyma interposed between the channels showed gliosis. The patient had not family history of cavernomas. After surgical removal, symptomatology completely remitted.

Bottom Line: Ten years later, at the age of 49, she consulted for progressive drug-resistant headache.MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole.Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome, Rome, Italy.

ABSTRACT
A correlation between radiation therapy and cavernoma has been suspected since 1994. Since then, only a few cases of radio-induced cavernomas have been reported in the literature (85 patients). Most of them were children, and the most frequent original tumour had been medulloblastoma. The authors report a case of two cystic cavernous angiomas after radiation therapy for atypical meningioma in adult woman. This is the first case of cavernous angioma after radiotherapy for low grade meningioma. A 39-year-old, Latin american woman was operated on for a frontal atypical meningioma with intradiploic component and adjuvant radiotherapy was delivered (6000 cGy local brain irradiation, fractionated over 6 weeks). Follow-up MR imaging showed no recurrences of the tumour and no other lesions. Ten years later, at the age of 49, she consulted for progressive drug-resistant headache. MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole. Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma. This is the first case of cavernous angioma after radiation therapy for atypical meningioma : it confirms the development of these lesions after standard radiation therapy also in patients previously affected by non-malignant tumours.

No MeSH data available.


Related in: MedlinePlus