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Two cystic cavernous angiomas after radiotherapy for atypical meningioma in adult woman : case report and literature review.

Ruggeri AG, Donnarumma P, Pichierri A, Delfini R - J Korean Neurosurg Soc (2014)

Bottom Line: Ten years later, at the age of 49, she consulted for progressive drug-resistant headache.MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole.Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome, Rome, Italy.

ABSTRACT
A correlation between radiation therapy and cavernoma has been suspected since 1994. Since then, only a few cases of radio-induced cavernomas have been reported in the literature (85 patients). Most of them were children, and the most frequent original tumour had been medulloblastoma. The authors report a case of two cystic cavernous angiomas after radiation therapy for atypical meningioma in adult woman. This is the first case of cavernous angioma after radiotherapy for low grade meningioma. A 39-year-old, Latin american woman was operated on for a frontal atypical meningioma with intradiploic component and adjuvant radiotherapy was delivered (6000 cGy local brain irradiation, fractionated over 6 weeks). Follow-up MR imaging showed no recurrences of the tumour and no other lesions. Ten years later, at the age of 49, she consulted for progressive drug-resistant headache. MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole. Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma. This is the first case of cavernous angioma after radiation therapy for atypical meningioma : it confirms the development of these lesions after standard radiation therapy also in patients previously affected by non-malignant tumours.

No MeSH data available.


Related in: MedlinePlus

Atypical menigioma. Axial T1-weighted MRI.
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Figure 1: Atypical menigioma. Axial T1-weighted MRI.

Mentions: A 49-year-old, Latin American, right handed, woman, at the age of 39 consulted for progressive swelling of the left frontal region. Magnetic Resonance (MR) scanning showed an intradiploic mass with dural attachment (Fig. 1). A Simpson I removal was achieved at the first operation; on histological examination (Fig. 2) the diagnosis was atypical meningioma (World Health Organization II).


Two cystic cavernous angiomas after radiotherapy for atypical meningioma in adult woman : case report and literature review.

Ruggeri AG, Donnarumma P, Pichierri A, Delfini R - J Korean Neurosurg Soc (2014)

Atypical menigioma. Axial T1-weighted MRI.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928347&req=5

Figure 1: Atypical menigioma. Axial T1-weighted MRI.
Mentions: A 49-year-old, Latin American, right handed, woman, at the age of 39 consulted for progressive swelling of the left frontal region. Magnetic Resonance (MR) scanning showed an intradiploic mass with dural attachment (Fig. 1). A Simpson I removal was achieved at the first operation; on histological examination (Fig. 2) the diagnosis was atypical meningioma (World Health Organization II).

Bottom Line: Ten years later, at the age of 49, she consulted for progressive drug-resistant headache.MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole.Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Sciences-Neurosurgery, Sapienza University of Rome, Rome, Italy.

ABSTRACT
A correlation between radiation therapy and cavernoma has been suspected since 1994. Since then, only a few cases of radio-induced cavernomas have been reported in the literature (85 patients). Most of them were children, and the most frequent original tumour had been medulloblastoma. The authors report a case of two cystic cavernous angiomas after radiation therapy for atypical meningioma in adult woman. This is the first case of cavernous angioma after radiotherapy for low grade meningioma. A 39-year-old, Latin american woman was operated on for a frontal atypical meningioma with intradiploic component and adjuvant radiotherapy was delivered (6000 cGy local brain irradiation, fractionated over 6 weeks). Follow-up MR imaging showed no recurrences of the tumour and no other lesions. Ten years later, at the age of 49, she consulted for progressive drug-resistant headache. MR imaging revealed two new well defined areas of different signal intensity at the surface of each frontal pole. Both lesions were surgically removed; the histopathological diagnosis was cavernous angioma. This is the first case of cavernous angioma after radiation therapy for atypical meningioma : it confirms the development of these lesions after standard radiation therapy also in patients previously affected by non-malignant tumours.

No MeSH data available.


Related in: MedlinePlus