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Reduction of death rate due to acute myocardial infarction in subjects with cancers through systemic restoration of impaired nitric oxide.

Ghosh R, Ray U, Jana P, Bhattacharya R, Banerjee D, Sinha A - PLoS ONE (2014)

Bottom Line: As the plasma NO level in AMI patients from two different ethnic groups was reduced to 0 µM (median) compared to 4.0 µM (median) in normal controls, the effect of restoration of the NO level to normal ranges on the rate of death due to AMI was determined.The use of SNP "pad" which normalized (≈4.0 µM) the plasma NO level that in consequence reduced the death rate due to AMI, among the participants, was found to be significantly reduced compared to the death due to AMI in normal population.Our data suggested that the use of SNP "pad" significantly reduced the death due to AMI. www.ctri.nic.in CTRI/2013/12/004236.

View Article: PubMed Central - PubMed

Affiliation: Sinha Institute of Medical Science and Technology, Kolkata, India.

ABSTRACT

Introduction: Excessive aggregation of platelets at the site of plaque rupture on the coronary artery led to the formation of thrombus which is reported to precipitate acute myocardial infarction (AMI). Nitric oxide (NO) has been reported to inhibit platelet aggregation and induce thrombolysis through the in situ formation of plasmin. As the plasma NO level in AMI patients from two different ethnic groups was reduced to 0 µM (median) compared to 4.0 µM (median) in normal controls, the effect of restoration of the NO level to normal ranges on the rate of death due to AMI was determined.

Methods and results: The restoration of plasma NO level was achieved by a sticking small cotton pad (10×25 mm) containing 0.28 mmol sodium nitroprusside (SNP) in 0.9% NaCl to the abdominal skin of the participants using non-toxic adhesive tape which was reported to normalize the plasma NO level. The participants (8,283) were volunteers in an independent study who had different kinds of cancers and did not wish to use any conventional therapy for their condition but opted to receive SNP "pad" for their condition for 3 years. The use of SNP "pad" which normalized (≈4.0 µM) the plasma NO level that in consequence reduced the death rate due to AMI, among the participants, was found to be significantly reduced compared to the death due to AMI in normal population.

Conclusion: Our data suggested that the use of SNP "pad" significantly reduced the death due to AMI.

Trial registration: www.ctri.nic.in CTRI/2013/12/004236.

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Related in: MedlinePlus

The age group-plasma NO level adjusted regression model in both Indian and Australian AMI patients.Regression model of the age related to the plasma NO level in both the Indian and Australian AMI patients was plotted. The age and the corresponding plasma NO level of the participants could be determined from the plot. Solid line represents the regression curve of the age group of the Indian AMI patients. Dotted line indicates the regression curve of the age group of the Australian AMI patients. Solid circles (•) indicate variations in the age group of Indian AMI patients. Solid squares (▪) indicate variations in the age group of the Australian AMI patients. The hollow circles (○) and the hollow squares (□) represent the plasma NO level in Indian and Australian patients respectively.
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pone-0088639-g003: The age group-plasma NO level adjusted regression model in both Indian and Australian AMI patients.Regression model of the age related to the plasma NO level in both the Indian and Australian AMI patients was plotted. The age and the corresponding plasma NO level of the participants could be determined from the plot. Solid line represents the regression curve of the age group of the Indian AMI patients. Dotted line indicates the regression curve of the age group of the Australian AMI patients. Solid circles (•) indicate variations in the age group of Indian AMI patients. Solid squares (▪) indicate variations in the age group of the Australian AMI patients. The hollow circles (○) and the hollow squares (□) represent the plasma NO level in Indian and Australian patients respectively.

Mentions: Regression curve of the plasma NO level and the age group demonstrated that the occurrence of AMI was prevalent in similar ranges of age group and the plasma NO level was found to hover around 0 nmol/h in both the groups of patient (Fig. 3). It can be concluded that both in Indian and Australian patients the age group and NO level are significant with r2 = 0.8021.


Reduction of death rate due to acute myocardial infarction in subjects with cancers through systemic restoration of impaired nitric oxide.

Ghosh R, Ray U, Jana P, Bhattacharya R, Banerjee D, Sinha A - PLoS ONE (2014)

The age group-plasma NO level adjusted regression model in both Indian and Australian AMI patients.Regression model of the age related to the plasma NO level in both the Indian and Australian AMI patients was plotted. The age and the corresponding plasma NO level of the participants could be determined from the plot. Solid line represents the regression curve of the age group of the Indian AMI patients. Dotted line indicates the regression curve of the age group of the Australian AMI patients. Solid circles (•) indicate variations in the age group of Indian AMI patients. Solid squares (▪) indicate variations in the age group of the Australian AMI patients. The hollow circles (○) and the hollow squares (□) represent the plasma NO level in Indian and Australian patients respectively.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928291&req=5

pone-0088639-g003: The age group-plasma NO level adjusted regression model in both Indian and Australian AMI patients.Regression model of the age related to the plasma NO level in both the Indian and Australian AMI patients was plotted. The age and the corresponding plasma NO level of the participants could be determined from the plot. Solid line represents the regression curve of the age group of the Indian AMI patients. Dotted line indicates the regression curve of the age group of the Australian AMI patients. Solid circles (•) indicate variations in the age group of Indian AMI patients. Solid squares (▪) indicate variations in the age group of the Australian AMI patients. The hollow circles (○) and the hollow squares (□) represent the plasma NO level in Indian and Australian patients respectively.
Mentions: Regression curve of the plasma NO level and the age group demonstrated that the occurrence of AMI was prevalent in similar ranges of age group and the plasma NO level was found to hover around 0 nmol/h in both the groups of patient (Fig. 3). It can be concluded that both in Indian and Australian patients the age group and NO level are significant with r2 = 0.8021.

Bottom Line: As the plasma NO level in AMI patients from two different ethnic groups was reduced to 0 µM (median) compared to 4.0 µM (median) in normal controls, the effect of restoration of the NO level to normal ranges on the rate of death due to AMI was determined.The use of SNP "pad" which normalized (≈4.0 µM) the plasma NO level that in consequence reduced the death rate due to AMI, among the participants, was found to be significantly reduced compared to the death due to AMI in normal population.Our data suggested that the use of SNP "pad" significantly reduced the death due to AMI. www.ctri.nic.in CTRI/2013/12/004236.

View Article: PubMed Central - PubMed

Affiliation: Sinha Institute of Medical Science and Technology, Kolkata, India.

ABSTRACT

Introduction: Excessive aggregation of platelets at the site of plaque rupture on the coronary artery led to the formation of thrombus which is reported to precipitate acute myocardial infarction (AMI). Nitric oxide (NO) has been reported to inhibit platelet aggregation and induce thrombolysis through the in situ formation of plasmin. As the plasma NO level in AMI patients from two different ethnic groups was reduced to 0 µM (median) compared to 4.0 µM (median) in normal controls, the effect of restoration of the NO level to normal ranges on the rate of death due to AMI was determined.

Methods and results: The restoration of plasma NO level was achieved by a sticking small cotton pad (10×25 mm) containing 0.28 mmol sodium nitroprusside (SNP) in 0.9% NaCl to the abdominal skin of the participants using non-toxic adhesive tape which was reported to normalize the plasma NO level. The participants (8,283) were volunteers in an independent study who had different kinds of cancers and did not wish to use any conventional therapy for their condition but opted to receive SNP "pad" for their condition for 3 years. The use of SNP "pad" which normalized (≈4.0 µM) the plasma NO level that in consequence reduced the death rate due to AMI, among the participants, was found to be significantly reduced compared to the death due to AMI in normal population.

Conclusion: Our data suggested that the use of SNP "pad" significantly reduced the death due to AMI.

Trial registration: www.ctri.nic.in CTRI/2013/12/004236.

Show MeSH
Related in: MedlinePlus