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Association of Fas -1377 G/A polymorphism with susceptibility to cancer.

Geng P, Li J, Ou J, Xie G, Wang N, Xiang L, Sa R, Liu C, Li H, Liang H - PLoS ONE (2014)

Bottom Line: However, the data presented inconsistent results.Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model.Statistical analyses were performed by using Stata software.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China.

ABSTRACT

Background: The relationship between Fas -1377 G/A polymorphism and cancer susceptibility has been implicated in accumulating data. However, the data presented inconsistent results. This study was devised to investigate the association of Fas -1377 G/A polymorphism and cancer susceptibility in a large number of participants.

Methods: The databases of PubMed, Embase, and Web of Science were searched and a total of 27 case-control studies including 13,355 cases and 16,078 controls were included in this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model. Statistical analyses were performed by using Stata software.

Results: The results suggested that Fas -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06-1.27, Pheterogeneity = 0.381; recessive model: OR, 1.19, 95%CI = 1.10-1.29, Pheterogeneity= 0.137). In the subgroup analysis by cancer type, significantly increased risk was observed in breast cancer (additive model: OR, 1.24, 95%CI = 1.04-1.58, Pheterogeneity = 0.614; recessive model: OR, 1.24, 95%CI = 1.02-1.51, Pheterogeneity = 0.349) and lung cancer (recessive model: OR, 1.25, 95%CI = 1.04-1.49, Pheterogeneity = 0.090). Similarly, elevated cancer risk associated with Fas -1377 G/A polymorphism was revealed in Asians.

Conclusions: The combined results suggest that Fas -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner.

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Related in: MedlinePlus

Flow diagram of study identification.
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pone-0088748-g001: Flow diagram of study identification.

Mentions: We initially identified 147 potentially relevant studies, of which 27 met the pre-described inclusion criteria and were included in the meta-analysis of the association between Fas -1377G/A polymorphism and cancer risk (Figure 1). Characteristics of all eligible case-control studies for the relationship of Fas -1377G/A polymorphism with cancer risk are summarized in Table 1. Of the twenty-seven studies included, an array of cancers including AML [6], [7], breast cancer [21]–[25], cervical cancer [26]–[28], lung cancer [8], [9], [29], [30], gastric cancer [31], [32], melanoma [33], [34], oral cancer [35], [36], and several other cancers [37]–[43] were involved. The subgroup analysis was carried out by cancer type, ethnicity and source of control, respectively. Genotype frequencies were available in all of the 27 studies.


Association of Fas -1377 G/A polymorphism with susceptibility to cancer.

Geng P, Li J, Ou J, Xie G, Wang N, Xiang L, Sa R, Liu C, Li H, Liang H - PLoS ONE (2014)

Flow diagram of study identification.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928286&req=5

pone-0088748-g001: Flow diagram of study identification.
Mentions: We initially identified 147 potentially relevant studies, of which 27 met the pre-described inclusion criteria and were included in the meta-analysis of the association between Fas -1377G/A polymorphism and cancer risk (Figure 1). Characteristics of all eligible case-control studies for the relationship of Fas -1377G/A polymorphism with cancer risk are summarized in Table 1. Of the twenty-seven studies included, an array of cancers including AML [6], [7], breast cancer [21]–[25], cervical cancer [26]–[28], lung cancer [8], [9], [29], [30], gastric cancer [31], [32], melanoma [33], [34], oral cancer [35], [36], and several other cancers [37]–[43] were involved. The subgroup analysis was carried out by cancer type, ethnicity and source of control, respectively. Genotype frequencies were available in all of the 27 studies.

Bottom Line: However, the data presented inconsistent results.Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model.Statistical analyses were performed by using Stata software.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University, Chongqing, P.R. China.

ABSTRACT

Background: The relationship between Fas -1377 G/A polymorphism and cancer susceptibility has been implicated in accumulating data. However, the data presented inconsistent results. This study was devised to investigate the association of Fas -1377 G/A polymorphism and cancer susceptibility in a large number of participants.

Methods: The databases of PubMed, Embase, and Web of Science were searched and a total of 27 case-control studies including 13,355 cases and 16,078 controls were included in this meta-analysis. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using the fixed-effects model. Statistical analyses were performed by using Stata software.

Results: The results suggested that Fas -1377 G/A polymorphism was overall associated with cancer susceptibility (additive model: OR, 1.16, 95%CI = 1.06-1.27, Pheterogeneity = 0.381; recessive model: OR, 1.19, 95%CI = 1.10-1.29, Pheterogeneity= 0.137). In the subgroup analysis by cancer type, significantly increased risk was observed in breast cancer (additive model: OR, 1.24, 95%CI = 1.04-1.58, Pheterogeneity = 0.614; recessive model: OR, 1.24, 95%CI = 1.02-1.51, Pheterogeneity = 0.349) and lung cancer (recessive model: OR, 1.25, 95%CI = 1.04-1.49, Pheterogeneity = 0.090). Similarly, elevated cancer risk associated with Fas -1377 G/A polymorphism was revealed in Asians.

Conclusions: The combined results suggest that Fas -1377 G/A polymorphism might modulate cancer susceptibility in an Asian-specific manner.

Show MeSH
Related in: MedlinePlus