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Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk.

Zhao H, Liu KJ, Lei ZD, Lei SL, Tian YQ - PLoS ONE (2014)

Bottom Line: GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17).Cumulative meta-analysis based on publication time confirmed these findings.Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Central South University, Changsha, China ; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.

ABSTRACT
A number of studies have explored the association of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and risk of colorectal cancer; however, the results are inconsistent. We performed this meta-analysis to clarify this issue using all the available evidence. Relevant studies were retrieved by searching PubMed. Eleven case-control studies were included in the meta-analysis, representing 2909 cases and 4903 controls. The pooled results based on all included studies showed a decreased colorectal cancer risk in the analysis of the GA genotype vs. the GG genotype (OR = 0.81, 95%CI = 0.68-0.98, p = 0.03) and in the dominant genetic model analysis (OR = 0.81, 95%CI = 0.67-0.98, p = 0.03). However, there was no statistical difference in the AA vs. GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17). Cumulative meta-analysis based on publication time confirmed these findings. Patients with colorectal cancer had a higher frequency of the GG genotype (OR = 1.10, 95% CI = 1.02-1.20, p = 0.02) and a lower frequency of the GA genotype (OR = 0.89, 95%CI = 0.81-0.98, p = 0.02) comparing with control population. Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.

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Funnel plot of ALDH2 Glu487Lys polymorphism and colorectal cancer risk for publication bias.
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pone-0088656-g005: Funnel plot of ALDH2 Glu487Lys polymorphism and colorectal cancer risk for publication bias.

Mentions: Potential publication bias was examined qualitatively by funnel plots and estimated quantitatively by Begg's and Egger's tests. As shown in Figure 5, the shapes of the funnel plots did not indicate any evidence of obvious asymmetry. Moreover, the p values from Begg's test and Egger's test were all greater than 0.05 (Table S2), indicating no publication bias


Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk.

Zhao H, Liu KJ, Lei ZD, Lei SL, Tian YQ - PLoS ONE (2014)

Funnel plot of ALDH2 Glu487Lys polymorphism and colorectal cancer risk for publication bias.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928247&req=5

pone-0088656-g005: Funnel plot of ALDH2 Glu487Lys polymorphism and colorectal cancer risk for publication bias.
Mentions: Potential publication bias was examined qualitatively by funnel plots and estimated quantitatively by Begg's and Egger's tests. As shown in Figure 5, the shapes of the funnel plots did not indicate any evidence of obvious asymmetry. Moreover, the p values from Begg's test and Egger's test were all greater than 0.05 (Table S2), indicating no publication bias

Bottom Line: GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17).Cumulative meta-analysis based on publication time confirmed these findings.Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Central South University, Changsha, China ; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.

ABSTRACT
A number of studies have explored the association of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and risk of colorectal cancer; however, the results are inconsistent. We performed this meta-analysis to clarify this issue using all the available evidence. Relevant studies were retrieved by searching PubMed. Eleven case-control studies were included in the meta-analysis, representing 2909 cases and 4903 controls. The pooled results based on all included studies showed a decreased colorectal cancer risk in the analysis of the GA genotype vs. the GG genotype (OR = 0.81, 95%CI = 0.68-0.98, p = 0.03) and in the dominant genetic model analysis (OR = 0.81, 95%CI = 0.67-0.98, p = 0.03). However, there was no statistical difference in the AA vs. GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17). Cumulative meta-analysis based on publication time confirmed these findings. Patients with colorectal cancer had a higher frequency of the GG genotype (OR = 1.10, 95% CI = 1.02-1.20, p = 0.02) and a lower frequency of the GA genotype (OR = 0.89, 95%CI = 0.81-0.98, p = 0.02) comparing with control population. Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.

Show MeSH
Related in: MedlinePlus