Limits...
Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk.

Zhao H, Liu KJ, Lei ZD, Lei SL, Tian YQ - PLoS ONE (2014)

Bottom Line: GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17).Cumulative meta-analysis based on publication time confirmed these findings.Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Central South University, Changsha, China ; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.

ABSTRACT
A number of studies have explored the association of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and risk of colorectal cancer; however, the results are inconsistent. We performed this meta-analysis to clarify this issue using all the available evidence. Relevant studies were retrieved by searching PubMed. Eleven case-control studies were included in the meta-analysis, representing 2909 cases and 4903 controls. The pooled results based on all included studies showed a decreased colorectal cancer risk in the analysis of the GA genotype vs. the GG genotype (OR = 0.81, 95%CI = 0.68-0.98, p = 0.03) and in the dominant genetic model analysis (OR = 0.81, 95%CI = 0.67-0.98, p = 0.03). However, there was no statistical difference in the AA vs. GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17). Cumulative meta-analysis based on publication time confirmed these findings. Patients with colorectal cancer had a higher frequency of the GG genotype (OR = 1.10, 95% CI = 1.02-1.20, p = 0.02) and a lower frequency of the GA genotype (OR = 0.89, 95%CI = 0.81-0.98, p = 0.02) comparing with control population. Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.

Show MeSH

Related in: MedlinePlus

Meta-analysis of ALDH2 Glu487Lys polymorphism and colorectal cancer: A) AA vs. GG analysis; B) GA vs. GG analysis; C) Dominant genetic model analysis; D) Recessive genetic model analysis.
© Copyright Policy
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3928247&req=5

pone-0088656-g002: Meta-analysis of ALDH2 Glu487Lys polymorphism and colorectal cancer: A) AA vs. GG analysis; B) GA vs. GG analysis; C) Dominant genetic model analysis; D) Recessive genetic model analysis.

Mentions: The pooled results based on all included studies showed a decreased risk in the analysis of the GA genotype vs. GG genotype (OR = 0.81, 95%CI = 0.68–0.98, p = 0.03) (Figure 2B) and in the dominant genetic model analysis (OR = 0.81, 95%CI = 0.67–0.98, p = 0.03) (Figure 2C). However, there was no statistical difference in the analysis of the AA vs. GG genotypes (OR = 0.74, 95%CI = 0.52–1.06, p = 0.11) (Figure 2A) or the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69–1.07, p = 0.17) (Figure 2D). Cumulative meta-analysis based on publication time further confirmed these findings (Figure 3). Furthermore, we calculated the genotype frequencies of GG, GA and AA based on-all included studies, and the results showed that patients with colorectal cancer had a higher frequency of the GG genotype (OR = 1.10, 95% CI = 1.02–1.20, p = 0.02) (Figure S1.A) and a lower frequency of the GA genotype (OR = 0.89, 95%CI = 0.81–0.98, p = 0.02) (Figure S1.B) comparing with the control population. However, there was no significant difference for the AA genotype (OR = 0.87, 95% CI = 0.70–1.08, p = 0.20) (Figure S1.C).


Meta-analysis of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and colorectal cancer risk.

Zhao H, Liu KJ, Lei ZD, Lei SL, Tian YQ - PLoS ONE (2014)

Meta-analysis of ALDH2 Glu487Lys polymorphism and colorectal cancer: A) AA vs. GG analysis; B) GA vs. GG analysis; C) Dominant genetic model analysis; D) Recessive genetic model analysis.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928247&req=5

pone-0088656-g002: Meta-analysis of ALDH2 Glu487Lys polymorphism and colorectal cancer: A) AA vs. GG analysis; B) GA vs. GG analysis; C) Dominant genetic model analysis; D) Recessive genetic model analysis.
Mentions: The pooled results based on all included studies showed a decreased risk in the analysis of the GA genotype vs. GG genotype (OR = 0.81, 95%CI = 0.68–0.98, p = 0.03) (Figure 2B) and in the dominant genetic model analysis (OR = 0.81, 95%CI = 0.67–0.98, p = 0.03) (Figure 2C). However, there was no statistical difference in the analysis of the AA vs. GG genotypes (OR = 0.74, 95%CI = 0.52–1.06, p = 0.11) (Figure 2A) or the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69–1.07, p = 0.17) (Figure 2D). Cumulative meta-analysis based on publication time further confirmed these findings (Figure 3). Furthermore, we calculated the genotype frequencies of GG, GA and AA based on-all included studies, and the results showed that patients with colorectal cancer had a higher frequency of the GG genotype (OR = 1.10, 95% CI = 1.02–1.20, p = 0.02) (Figure S1.A) and a lower frequency of the GA genotype (OR = 0.89, 95%CI = 0.81–0.98, p = 0.02) (Figure S1.B) comparing with the control population. However, there was no significant difference for the AA genotype (OR = 0.87, 95% CI = 0.70–1.08, p = 0.20) (Figure S1.C).

Bottom Line: GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17).Cumulative meta-analysis based on publication time confirmed these findings.Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.

View Article: PubMed Central - PubMed

Affiliation: School of Public Health, Central South University, Changsha, China ; Department of General Surgery, the Second Xiangya Hospital, Central South University, Changsha, China.

ABSTRACT
A number of studies have explored the association of the aldehyde dehydrogenases-2 (ALDH2) Glu487Lys polymorphism and risk of colorectal cancer; however, the results are inconsistent. We performed this meta-analysis to clarify this issue using all the available evidence. Relevant studies were retrieved by searching PubMed. Eleven case-control studies were included in the meta-analysis, representing 2909 cases and 4903 controls. The pooled results based on all included studies showed a decreased colorectal cancer risk in the analysis of the GA genotype vs. the GG genotype (OR = 0.81, 95%CI = 0.68-0.98, p = 0.03) and in the dominant genetic model analysis (OR = 0.81, 95%CI = 0.67-0.98, p = 0.03). However, there was no statistical difference in the AA vs. GG analysis (OR = 0.74, 95%CI = 0.52-1.06,p = 0.11) and the recessive genetic model analysis (OR = 0.86, 95%CI = 0.69-1.07, p = 0.17). Cumulative meta-analysis based on publication time confirmed these findings. Patients with colorectal cancer had a higher frequency of the GG genotype (OR = 1.10, 95% CI = 1.02-1.20, p = 0.02) and a lower frequency of the GA genotype (OR = 0.89, 95%CI = 0.81-0.98, p = 0.02) comparing with control population. Our results suggested that the ALDH2 Glu487Lys polymorphism may be associated with a decreased risk of colorectal cancer.

Show MeSH
Related in: MedlinePlus