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Neuronal correlates of maladaptive coping: an EEG-study in tinnitus patients.

Vanneste S, Joos K, Langguth B, To WT, De Ridder D - PLoS ONE (2014)

Bottom Line: Based on resting state EEG recordings, coping related differences in brain activity and connectivity were found.Correlation analysis revealed that the changes in the DLPFC correlate primarily with maladaptive coping behavior, whereas the changes in the sgACC correlate with tinnitus severity and depression.Our findings are in line with previous research in the field of depression that during resting state a alpha band hyperconnectivity exists within the default network for patients who use a maladaptive coping style, with the sgACC as the dysfunctional node and that the strength of the connectivity is related to focusing on negative mood and catastrophizing about the consequences of tinnitus.

View Article: PubMed Central - PubMed

Affiliation: Department of Translational Neuroscience, Faculty of Medicine, University of Antwerp, Antwerp, Belgium ; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas, United States of America.

ABSTRACT
Here we aimed to investigate the neuronal correlates of different coping styles in patients suffering from chronic tinnitus. Adaptive and maladaptive coping styles were determined in 85 tinnitus patients. Based on resting state EEG recordings, coping related differences in brain activity and connectivity were found. Maladaptive coping behavior was related to increases in subjective tinnitus loudness and distress, higher tinnitus severity and higher depression scores. EEG recordings demonstrated increased alpha activity over the left dorsolateral prefrontal cortex (DLPFC) and subgenual anterior cingulate cortex (sgACC) as well as increased connectivity in the default (i.e. resting state) network in tinnitus patients with a maladaptive coping style. Correlation analysis revealed that the changes in the DLPFC correlate primarily with maladaptive coping behavior, whereas the changes in the sgACC correlate with tinnitus severity and depression. Our findings are in line with previous research in the field of depression that during resting state a alpha band hyperconnectivity exists within the default network for patients who use a maladaptive coping style, with the sgACC as the dysfunctional node and that the strength of the connectivity is related to focusing on negative mood and catastrophizing about the consequences of tinnitus.

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(A) Increased activity in the left dorsolateral prefrontal cortex (BA9) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for the frequency band Alpha1. (B) Region of interest analysis shows increased activity in the left dorsolateral prefrontal cortex (BA9) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for Alpha1. (C & D) Increased activity in the subgenual anterior cingulate cortex (BA25) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for the frequency band Alpha2. (E) Region of interest analysis shows increased activity in the subgenual anterior cingulate cortex (BA25) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for Alpha2.
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pone-0088253-g002: (A) Increased activity in the left dorsolateral prefrontal cortex (BA9) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for the frequency band Alpha1. (B) Region of interest analysis shows increased activity in the left dorsolateral prefrontal cortex (BA9) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for Alpha1. (C & D) Increased activity in the subgenual anterior cingulate cortex (BA25) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for the frequency band Alpha2. (E) Region of interest analysis shows increased activity in the subgenual anterior cingulate cortex (BA25) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for Alpha2.

Mentions: For the alpha 1 and alpha2 band sLORETA revealed a higher current source density for the maladaptive coping style as compared to the adaptive coping style over the left dorsolateral prefrontal cortex (DLFPC) (Figure 2A) and sgACC (BA25) (Figure 2C&D). In the other frequency bands (delta, theta, beta 1, beta 2, beta 3 and gamma) there were no statistically significant differences between the two groups.


Neuronal correlates of maladaptive coping: an EEG-study in tinnitus patients.

Vanneste S, Joos K, Langguth B, To WT, De Ridder D - PLoS ONE (2014)

(A) Increased activity in the left dorsolateral prefrontal cortex (BA9) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for the frequency band Alpha1. (B) Region of interest analysis shows increased activity in the left dorsolateral prefrontal cortex (BA9) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for Alpha1. (C & D) Increased activity in the subgenual anterior cingulate cortex (BA25) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for the frequency band Alpha2. (E) Region of interest analysis shows increased activity in the subgenual anterior cingulate cortex (BA25) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for Alpha2.
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3928191&req=5

pone-0088253-g002: (A) Increased activity in the left dorsolateral prefrontal cortex (BA9) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for the frequency band Alpha1. (B) Region of interest analysis shows increased activity in the left dorsolateral prefrontal cortex (BA9) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for Alpha1. (C & D) Increased activity in the subgenual anterior cingulate cortex (BA25) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for the frequency band Alpha2. (E) Region of interest analysis shows increased activity in the subgenual anterior cingulate cortex (BA25) for tinnitus patients using a maladaptive coping style in comparison to tinnitus patients using an adaptive coping style for Alpha2.
Mentions: For the alpha 1 and alpha2 band sLORETA revealed a higher current source density for the maladaptive coping style as compared to the adaptive coping style over the left dorsolateral prefrontal cortex (DLFPC) (Figure 2A) and sgACC (BA25) (Figure 2C&D). In the other frequency bands (delta, theta, beta 1, beta 2, beta 3 and gamma) there were no statistically significant differences between the two groups.

Bottom Line: Based on resting state EEG recordings, coping related differences in brain activity and connectivity were found.Correlation analysis revealed that the changes in the DLPFC correlate primarily with maladaptive coping behavior, whereas the changes in the sgACC correlate with tinnitus severity and depression.Our findings are in line with previous research in the field of depression that during resting state a alpha band hyperconnectivity exists within the default network for patients who use a maladaptive coping style, with the sgACC as the dysfunctional node and that the strength of the connectivity is related to focusing on negative mood and catastrophizing about the consequences of tinnitus.

View Article: PubMed Central - PubMed

Affiliation: Department of Translational Neuroscience, Faculty of Medicine, University of Antwerp, Antwerp, Belgium ; School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, Texas, United States of America.

ABSTRACT
Here we aimed to investigate the neuronal correlates of different coping styles in patients suffering from chronic tinnitus. Adaptive and maladaptive coping styles were determined in 85 tinnitus patients. Based on resting state EEG recordings, coping related differences in brain activity and connectivity were found. Maladaptive coping behavior was related to increases in subjective tinnitus loudness and distress, higher tinnitus severity and higher depression scores. EEG recordings demonstrated increased alpha activity over the left dorsolateral prefrontal cortex (DLPFC) and subgenual anterior cingulate cortex (sgACC) as well as increased connectivity in the default (i.e. resting state) network in tinnitus patients with a maladaptive coping style. Correlation analysis revealed that the changes in the DLPFC correlate primarily with maladaptive coping behavior, whereas the changes in the sgACC correlate with tinnitus severity and depression. Our findings are in line with previous research in the field of depression that during resting state a alpha band hyperconnectivity exists within the default network for patients who use a maladaptive coping style, with the sgACC as the dysfunctional node and that the strength of the connectivity is related to focusing on negative mood and catastrophizing about the consequences of tinnitus.

Show MeSH
Related in: MedlinePlus