Porcine incisional hernia model: Evaluation of biologically derived intact extracellular matrix repairs.
Bottom Line: Mechanical remodeling of porcine-derived acellular dermal matrix was noted over time.Porcine-derived acellular dermal matrix elastic modulus and ultimate tensile stress were similar to fascia at 6 weeks.In this study, porcine-derived acellular dermal matrix-reinforced repairs provided more complete wound healing response compared with primary closure.
Affiliation: LifeCell Corporation, Inc., Branchburg, NJ, USA.
We compared fascial wounds repaired with non-cross-linked intact porcine-derived acellular dermal matrix versus primary closure in a large-animal hernia model. Incisional hernias were created in Yucatan pigs and repaired after 3 weeks via open technique with suture-only primary closure or intraperitoneally placed porcine-derived acellular dermal matrix. Progressive changes in mechanical and biological properties of porcine-derived acellular dermal matrix and repair sites were assessed. Porcine-derived acellular dermal matrix-repaired hernias of additional animals were evaluated 2 and 4 weeks post incision to assess porcine-derived acellular dermal matrix regenerative potential and biomechanical changes. Hernias repaired with primary closure showed substantially more scarring and bone hyperplasia along the incision line. Mechanical remodeling of porcine-derived acellular dermal matrix was noted over time. Porcine-derived acellular dermal matrix elastic modulus and ultimate tensile stress were similar to fascia at 6 weeks. The biology of porcine-derived acellular dermal matrix-reinforced animals was more similar to native abdominal wall versus that with primary closure. In this study, porcine-derived acellular dermal matrix-reinforced repairs provided more complete wound healing response compared with primary closure.
No MeSH data available.
Related in: MedlinePlus
License 1 - License 2 - License 3
Mentions: Rapid cell infiltration and vasculature formation were noted in all PADM-reinforced animals (Figure 3). No differences were noted between herniated and nonherniated animals. Inflammation in the PADM group was mild and limited to suture locations. Inflammation in the suture-only group was comparable to the PADM group at week 6. Inflammation in fascia surrounding the PADM was minimal for both suture-only and PADM groups (Figure 4, Table 1).
No MeSH data available.