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Kaposi`s sarcoma associated herpesvirus infection among female sex workers and general population women in Shanghai, China: a cross-sectional study.

Zhang T, Yang Y, Yu F, Zhao Y, Lin F, Minhas V, Wood C, He N - BMC Infect. Dis. (2014)

Bottom Line: An anonymous questionnaire interview was administrated among 600 FSW and 600 GW.None of the study participants were tested positive for HIV.KSHV is moderately and equivalently prevalent among FSW and GW.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Epidemiology, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China. nhe@shmu.edu.cn.

ABSTRACT

Background: Limited information on epidemiologic patterns of KSHV, with none focusing on heterosexual transmission, is available in mainland China. To clarify this, a cross-sectional study was conducted among a group of female sex workers (FSW) and general population women (GW) in Shanghai, China.

Methods: An anonymous questionnaire interview was administrated among 600 FSW and 600 GW. Blood samples were collected and tested for antibodies to KSHV, HSV-2, HIV, syphilis and HBsAg. Correlates of KSHV and HSV-2 were examined using multiple logistic regression analysis.

Results: None of the study participants were tested positive for HIV. The seroprevalence of KSHV, HSV-2 , HBV and syphilis was 10.0%, 52.2%, 12.3% and 10.5%, respectively for FSW, and was 11.0%, 15.3%, 9.8% and 2.8%, respectively for GW. KSHV seropositivity was not associated with syphilis and HSV-2 infection as well as sexual practices among either FSW or GW. Nevertheless, HSV-2 infection among FSW was independently associated with being ever married (OR = 1.59; 95%CI: 1.04-2.45), >5 years of prostitution (OR = 2.06; 95%CI: 1.16-3.68) and being syphilis positive (OR = 2.65; 95%CI: 1.43-4.93). HSV-2 infection among GW was independently associated with an age of >35 years (OR = 2.29; 95%CI: 1.07-4.93), having had more than 2 sex partners in the prior 12 months (OR = 6.44; 95%CI: 1.67-24.93) and being syphilis positive (OR = 3.94; 95%CI: 1.38-11.23). A gradual increase of prevalence with the prostitution time group was also detected for HSV-2 and syphilis, but not for KSHV.

Conclusions: KSHV is moderately and equivalently prevalent among FSW and GW. Heterosexual contact is not a predominant route for KSHV transmission among Chinese women.

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Seroprevalence of KSHV, syphilis and HSV2 among female sex workers according to years of prostitution.
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Figure 1: Seroprevalence of KSHV, syphilis and HSV2 among female sex workers according to years of prostitution.

Mentions: To explore independent associates of KSHV and HSV-2 infections among FSW, two multivariate logistic analyses were performed while adjusting for potential confounding variables. As presented in Table 2, KSHV infection among FSW was not significantly associated with any of the variables listed in the table including those reflecting sexual practices. Nonetheless, HSV-2 infection was significantly associated with marital status, years of prostitution and syphilis infection among FSW. Those who were ever married (OR, 1.59; 95%CI, 1.04-2.45), had been in prostitution for >5 years (OR, 2.06; 95%CI, 1.16-3.68) and were infected with syphilis (OR, 2.65; 95%CI, 1.43-4.93) were more likely to be infected with HSV-2. Furthermore, when analyzed with duration of prostitution, no difference for KSHV seroprevalence was detected across different durations of prostitution (Chi sqauretrend =0.326, P = 0.747). However, a positive linear association between HSV-2 seroprevalence and years of prostitution was observed among FSW (Chi sqauretrend = 2.922, P < 0.01) (Figure 1).


Kaposi`s sarcoma associated herpesvirus infection among female sex workers and general population women in Shanghai, China: a cross-sectional study.

Zhang T, Yang Y, Yu F, Zhao Y, Lin F, Minhas V, Wood C, He N - BMC Infect. Dis. (2014)

Seroprevalence of KSHV, syphilis and HSV2 among female sex workers according to years of prostitution.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927852&req=5

Figure 1: Seroprevalence of KSHV, syphilis and HSV2 among female sex workers according to years of prostitution.
Mentions: To explore independent associates of KSHV and HSV-2 infections among FSW, two multivariate logistic analyses were performed while adjusting for potential confounding variables. As presented in Table 2, KSHV infection among FSW was not significantly associated with any of the variables listed in the table including those reflecting sexual practices. Nonetheless, HSV-2 infection was significantly associated with marital status, years of prostitution and syphilis infection among FSW. Those who were ever married (OR, 1.59; 95%CI, 1.04-2.45), had been in prostitution for >5 years (OR, 2.06; 95%CI, 1.16-3.68) and were infected with syphilis (OR, 2.65; 95%CI, 1.43-4.93) were more likely to be infected with HSV-2. Furthermore, when analyzed with duration of prostitution, no difference for KSHV seroprevalence was detected across different durations of prostitution (Chi sqauretrend =0.326, P = 0.747). However, a positive linear association between HSV-2 seroprevalence and years of prostitution was observed among FSW (Chi sqauretrend = 2.922, P < 0.01) (Figure 1).

Bottom Line: An anonymous questionnaire interview was administrated among 600 FSW and 600 GW.None of the study participants were tested positive for HIV.KSHV is moderately and equivalently prevalent among FSW and GW.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Epidemiology, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China. nhe@shmu.edu.cn.

ABSTRACT

Background: Limited information on epidemiologic patterns of KSHV, with none focusing on heterosexual transmission, is available in mainland China. To clarify this, a cross-sectional study was conducted among a group of female sex workers (FSW) and general population women (GW) in Shanghai, China.

Methods: An anonymous questionnaire interview was administrated among 600 FSW and 600 GW. Blood samples were collected and tested for antibodies to KSHV, HSV-2, HIV, syphilis and HBsAg. Correlates of KSHV and HSV-2 were examined using multiple logistic regression analysis.

Results: None of the study participants were tested positive for HIV. The seroprevalence of KSHV, HSV-2 , HBV and syphilis was 10.0%, 52.2%, 12.3% and 10.5%, respectively for FSW, and was 11.0%, 15.3%, 9.8% and 2.8%, respectively for GW. KSHV seropositivity was not associated with syphilis and HSV-2 infection as well as sexual practices among either FSW or GW. Nevertheless, HSV-2 infection among FSW was independently associated with being ever married (OR = 1.59; 95%CI: 1.04-2.45), >5 years of prostitution (OR = 2.06; 95%CI: 1.16-3.68) and being syphilis positive (OR = 2.65; 95%CI: 1.43-4.93). HSV-2 infection among GW was independently associated with an age of >35 years (OR = 2.29; 95%CI: 1.07-4.93), having had more than 2 sex partners in the prior 12 months (OR = 6.44; 95%CI: 1.67-24.93) and being syphilis positive (OR = 3.94; 95%CI: 1.38-11.23). A gradual increase of prevalence with the prostitution time group was also detected for HSV-2 and syphilis, but not for KSHV.

Conclusions: KSHV is moderately and equivalently prevalent among FSW and GW. Heterosexual contact is not a predominant route for KSHV transmission among Chinese women.

Show MeSH
Related in: MedlinePlus