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Effects of rutin on acrylamide-induced neurotoxicity.

Motamedshariaty VS, Amel Farzad S, Nassiri-Asl M, Hosseinzadeh H - Daru (2014)

Bottom Line: Rutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners.The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg).It seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pharmacodynamics and Toxicological Department, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. hosseinzadehh@mums.ac.ir.

ABSTRACT

Background: Rutin is an important flavonoid that is consumed in the daily diet. The cytoprotective effects of rutin, including antioxidative, and neuroprotective have been shown in several studies. Neurotoxic effects of acrylamide (ACR) have been established in humans and animals. In this study, the protective effects of rutin in prevention and treatment of neural toxicity of ACR were studied.

Results: Rutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners. Rutin treatment decreased the ACR-induced cytotoxicity significantly in comparison to control (P <0.01, P < 0.001). Rutin (100 and 200 mg/kg) could prevent decrease of body weight in rats. In combination treatments with rutin (50, 100 and 200 mg/kg), vitamin E (200 mg/kg) and ACR, gait abnormalities significantly decreased in a dose-dependent manner (P < 0.01 and P < 0.001). The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg).

Conclusion: It seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

No MeSH data available.


Related in: MedlinePlus

Therapeutic effect of rutin (after 14 days of ACR exposure) by comparison between the initial and end weight of rats. Data are expressed as mean ± SEM, (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 vs. first weight of each group treated with drugs.
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Figure 4: Therapeutic effect of rutin (after 14 days of ACR exposure) by comparison between the initial and end weight of rats. Data are expressed as mean ± SEM, (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 vs. first weight of each group treated with drugs.

Mentions: In the control group, only the body weight increased after 14 days compared with the first weight (P < 0.01). In other groups, the body weight significantly decreased compared with the first weight. However, in the group administered vitamin E, there was no significant change in body weight after 3 days (Figure 4).


Effects of rutin on acrylamide-induced neurotoxicity.

Motamedshariaty VS, Amel Farzad S, Nassiri-Asl M, Hosseinzadeh H - Daru (2014)

Therapeutic effect of rutin (after 14 days of ACR exposure) by comparison between the initial and end weight of rats. Data are expressed as mean ± SEM, (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 vs. first weight of each group treated with drugs.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927829&req=5

Figure 4: Therapeutic effect of rutin (after 14 days of ACR exposure) by comparison between the initial and end weight of rats. Data are expressed as mean ± SEM, (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 vs. first weight of each group treated with drugs.
Mentions: In the control group, only the body weight increased after 14 days compared with the first weight (P < 0.01). In other groups, the body weight significantly decreased compared with the first weight. However, in the group administered vitamin E, there was no significant change in body weight after 3 days (Figure 4).

Bottom Line: Rutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners.The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg).It seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

View Article: PubMed Central - HTML - PubMed

Affiliation: Pharmacodynamics and Toxicological Department, Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. hosseinzadehh@mums.ac.ir.

ABSTRACT

Background: Rutin is an important flavonoid that is consumed in the daily diet. The cytoprotective effects of rutin, including antioxidative, and neuroprotective have been shown in several studies. Neurotoxic effects of acrylamide (ACR) have been established in humans and animals. In this study, the protective effects of rutin in prevention and treatment of neural toxicity of ACR were studied.

Results: Rutin significantly reduced cell death induced by ACR (5.46 mM) in time- and dose-dependent manners. Rutin treatment decreased the ACR-induced cytotoxicity significantly in comparison to control (P <0.01, P < 0.001). Rutin (100 and 200 mg/kg) could prevent decrease of body weight in rats. In combination treatments with rutin (50, 100 and 200 mg/kg), vitamin E (200 mg/kg) and ACR, gait abnormalities significantly decreased in a dose-dependent manner (P < 0.01 and P < 0.001). The level of malondialdehyde significantly decreased in the brain tissue of rats in both preventive and therapeutic groups that received rutin (100 and 200 mg/kg).

Conclusion: It seems that rutin could be effective in reducing neurotoxicity and the neuroprotective effect of it might be mediated via antioxidant activity.

No MeSH data available.


Related in: MedlinePlus