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Spinal fusion in the next generation: gene and cell therapy approaches.

Barba M, Cicione C, Bernardini C, Campana V, Pagano E, Michetti F, Logroscino G, Lattanzi W - ScientificWorldJournal (2014)

Bottom Line: However, a high morbidity is associated with the harvest procedure.In recent years, cell and gene therapies have attracted great interest from the scientific community.The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications.

View Article: PubMed Central - PubMed

Affiliation: Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy.

ABSTRACT
Bone fusion represents a challenge in the orthopedics practice, being especially indicated for spine disorders. Spinal fusion can be defined as the bony union between two vertebral bodies obtained through the surgical introduction of an osteoconductive, osteoinductive, and osteogenic compound. Autogenous bone graft provides all these three qualities and is considered the gold standard. However, a high morbidity is associated with the harvest procedure. Intensive research efforts have been spent during the last decades to develop new approaches and technologies for successful spine fusion. In recent years, cell and gene therapies have attracted great interest from the scientific community. The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications. In this review we aim to describe the developing gene- and cell-based bone regenerative approaches as promising future trends in spine fusion.

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Related in: MedlinePlus

Spinal fusion clinical trials. Graphical view of the 304 clinical trials from http://www.clinicaltrials.gov/; 91 of these are open (a). In particular, spinal fusion clinical trials based on stem cell-therapy are 15; 1 of these is open (b).
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3927763&req=5

fig1: Spinal fusion clinical trials. Graphical view of the 304 clinical trials from http://www.clinicaltrials.gov/; 91 of these are open (a). In particular, spinal fusion clinical trials based on stem cell-therapy are 15; 1 of these is open (b).

Mentions: A single clinical trial testing ex vivo expanded autologous BM-MSC for spinal fusion in spine degenerative diseases seems to be open, according to publicly available information (Figure 1; http://www.clinicaltrials.gov/).


Spinal fusion in the next generation: gene and cell therapy approaches.

Barba M, Cicione C, Bernardini C, Campana V, Pagano E, Michetti F, Logroscino G, Lattanzi W - ScientificWorldJournal (2014)

Spinal fusion clinical trials. Graphical view of the 304 clinical trials from http://www.clinicaltrials.gov/; 91 of these are open (a). In particular, spinal fusion clinical trials based on stem cell-therapy are 15; 1 of these is open (b).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3927763&req=5

fig1: Spinal fusion clinical trials. Graphical view of the 304 clinical trials from http://www.clinicaltrials.gov/; 91 of these are open (a). In particular, spinal fusion clinical trials based on stem cell-therapy are 15; 1 of these is open (b).
Mentions: A single clinical trial testing ex vivo expanded autologous BM-MSC for spinal fusion in spine degenerative diseases seems to be open, according to publicly available information (Figure 1; http://www.clinicaltrials.gov/).

Bottom Line: However, a high morbidity is associated with the harvest procedure.In recent years, cell and gene therapies have attracted great interest from the scientific community.The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications.

View Article: PubMed Central - PubMed

Affiliation: Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Largo Francesco Vito, 1, 00168 Rome, Italy.

ABSTRACT
Bone fusion represents a challenge in the orthopedics practice, being especially indicated for spine disorders. Spinal fusion can be defined as the bony union between two vertebral bodies obtained through the surgical introduction of an osteoconductive, osteoinductive, and osteogenic compound. Autogenous bone graft provides all these three qualities and is considered the gold standard. However, a high morbidity is associated with the harvest procedure. Intensive research efforts have been spent during the last decades to develop new approaches and technologies for successful spine fusion. In recent years, cell and gene therapies have attracted great interest from the scientific community. The improved knowledge of both mesenchymal stem cell biology and osteogenic molecules allowed their use in regenerative medicine, representing attractive approaches to achieve bone regeneration also in spinal surgery applications. In this review we aim to describe the developing gene- and cell-based bone regenerative approaches as promising future trends in spine fusion.

Show MeSH
Related in: MedlinePlus