Limits...
Lower Left Thalamic Myo-Inositol Levels Associated with Greater Cognitive Impulsivity in Marijuana-Dependent Young Men: Preliminary Spectroscopic Evidence at 4T.

Mashhoon Y, Jensen JE, Sneider JT, Yurgelun-Todd DA, Silveri MM - J Addict Res Ther (2013)

Bottom Line: MRJ users exhibited significantly reduced mI levels in the left thalamus (lThal), relative to non-using participants, which were associated with elevated cognitive impulsivity.Other regional analyses did not reveal any significant group differences.The current findings indicate that reduced mI levels are regionally specific to the lThal in MRJ users.

View Article: PubMed Central - PubMed

Affiliation: McLean Hospital/Harvard Medical School, 115 Mill St., Belmont, MA 02478, USA.

ABSTRACT
The effects of chronic marijuana (MRJ) use on neurochemistry are not well characterized. Previously, altered global myo-Inositol (mI) concentrations and distribution in white matter were associated with impulsivity and mood symptoms in young MRJ-dependent men. The objective of this study was to retrospectively examine previously collected data, to investigate the potential regional specificity of metabolite levels in brain regions densely packed with cannabinoid receptors. Spectra were acquired at 4.0 Tesla using 2D J-resolved proton magnetic resonance spectroscopic imaging (MRSI) to quantify the entire J-coupled spectral surface of metabolites from voxels in regions of interest. For the current regional spectral analyses, a 2D-JMRSI grid was positioned over the central axial slice and shifted in the x and y dimensions to optimally position voxels over regions containing thalamus, temporal lobe, and parieto-occipital cortex. MRJ users exhibited significantly reduced mI levels in the left thalamus (lThal), relative to non-using participants, which were associated with elevated cognitive impulsivity. Other regional analyses did not reveal any significant group differences. The current findings indicate that reduced mI levels are regionally specific to the lThal in MRJ users. Furthermore, findings suggest that mI and the lThal uniquely contribute to elevated impulsivity.

No MeSH data available.


Related in: MedlinePlus

Myo-Inositol (mI)/Creatine (Cr) ratios in the left thalamus (lThal) in NU and MRJ-using groups are shown. A. Significant group differences in mI/Cr ratios. Values are the means ± SD. *p=0.05 relative to NU lThal mI/Cr ratios. B. Scatterplot showing significant correlation between mI/Cr ratios and reported BIS-11 cognitive impulsivity subscale scores.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC3927647&req=5

Figure 3: Myo-Inositol (mI)/Creatine (Cr) ratios in the left thalamus (lThal) in NU and MRJ-using groups are shown. A. Significant group differences in mI/Cr ratios. Values are the means ± SD. *p=0.05 relative to NU lThal mI/Cr ratios. B. Scatterplot showing significant correlation between mI/Cr ratios and reported BIS-11 cognitive impulsivity subscale scores.

Mentions: Analyses of thalamic metabolite levels revealed a significant group × hemisphere interaction (F[1,15]=4.53, p=0.05; ES=0.78; Figure 3A), indicating that left Thal mI/Cr ratios were significantly lower in MRJ users relative to NU comparisons. Right Thal mI/Cr levels and other regional analyses of metabolite ratios did not reveal any significant differences between groups (Table 1).


Lower Left Thalamic Myo-Inositol Levels Associated with Greater Cognitive Impulsivity in Marijuana-Dependent Young Men: Preliminary Spectroscopic Evidence at 4T.

Mashhoon Y, Jensen JE, Sneider JT, Yurgelun-Todd DA, Silveri MM - J Addict Res Ther (2013)

Myo-Inositol (mI)/Creatine (Cr) ratios in the left thalamus (lThal) in NU and MRJ-using groups are shown. A. Significant group differences in mI/Cr ratios. Values are the means ± SD. *p=0.05 relative to NU lThal mI/Cr ratios. B. Scatterplot showing significant correlation between mI/Cr ratios and reported BIS-11 cognitive impulsivity subscale scores.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927647&req=5

Figure 3: Myo-Inositol (mI)/Creatine (Cr) ratios in the left thalamus (lThal) in NU and MRJ-using groups are shown. A. Significant group differences in mI/Cr ratios. Values are the means ± SD. *p=0.05 relative to NU lThal mI/Cr ratios. B. Scatterplot showing significant correlation between mI/Cr ratios and reported BIS-11 cognitive impulsivity subscale scores.
Mentions: Analyses of thalamic metabolite levels revealed a significant group × hemisphere interaction (F[1,15]=4.53, p=0.05; ES=0.78; Figure 3A), indicating that left Thal mI/Cr ratios were significantly lower in MRJ users relative to NU comparisons. Right Thal mI/Cr levels and other regional analyses of metabolite ratios did not reveal any significant differences between groups (Table 1).

Bottom Line: MRJ users exhibited significantly reduced mI levels in the left thalamus (lThal), relative to non-using participants, which were associated with elevated cognitive impulsivity.Other regional analyses did not reveal any significant group differences.The current findings indicate that reduced mI levels are regionally specific to the lThal in MRJ users.

View Article: PubMed Central - PubMed

Affiliation: McLean Hospital/Harvard Medical School, 115 Mill St., Belmont, MA 02478, USA.

ABSTRACT
The effects of chronic marijuana (MRJ) use on neurochemistry are not well characterized. Previously, altered global myo-Inositol (mI) concentrations and distribution in white matter were associated with impulsivity and mood symptoms in young MRJ-dependent men. The objective of this study was to retrospectively examine previously collected data, to investigate the potential regional specificity of metabolite levels in brain regions densely packed with cannabinoid receptors. Spectra were acquired at 4.0 Tesla using 2D J-resolved proton magnetic resonance spectroscopic imaging (MRSI) to quantify the entire J-coupled spectral surface of metabolites from voxels in regions of interest. For the current regional spectral analyses, a 2D-JMRSI grid was positioned over the central axial slice and shifted in the x and y dimensions to optimally position voxels over regions containing thalamus, temporal lobe, and parieto-occipital cortex. MRJ users exhibited significantly reduced mI levels in the left thalamus (lThal), relative to non-using participants, which were associated with elevated cognitive impulsivity. Other regional analyses did not reveal any significant group differences. The current findings indicate that reduced mI levels are regionally specific to the lThal in MRJ users. Furthermore, findings suggest that mI and the lThal uniquely contribute to elevated impulsivity.

No MeSH data available.


Related in: MedlinePlus