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The innervation of the human acetabular labrum and hip joint: an anatomic study.

Alzaharani A, Bali K, Gudena R, Railton P, Ponjevic D, Matyas JR, Powell JN - BMC Musculoskelet Disord (2014)

Bottom Line: FNEs and NEOs were more frequently seen in the antero-superior and postero-superior zones.Four specimens had abundant vascularity and disorganised architecture of FNEs in the deeper zones of the antero-superior quadrant suggestive of a healed tear.These are more abundant in the antero-superior and postero-superior zones.

View Article: PubMed Central - HTML - PubMed

Affiliation: Orthopedic Trauma & Lower Extremity Reconstruction, 3134 Hospital Drive N,W, Calgary, Alberta T2N 5A1, Canada. jnpowellemail@yahoo.ca.

ABSTRACT

Background: The aim of the current study was to evaluate the innervation of the acetabular labrum in the various zones and to understand its potential role in nociception and proprioception in hips with labral pathology.

Methods: A total of twenty hip labrums were tagged and excised intraoperatively from patients undergoing a total hip replacement. After preparation, the specimens were cut to a thickness of 10 μm and divided into four quadrants (zones) using a clock face pattern. Neurosensory structure distribution was then evaluated using Hematoxylin and Eosin (H and E), and immunoreactivity to S-100.

Results: All specimens had abundant free nerve endings (FNEs). These were seen predominantly superficially and on the chondral side of the labrum. In addition, predominantly three different types of nerve end organs (NEOs) were identified in all twenty specimens. FNEs and NEOs were more frequently seen in the antero-superior and postero-superior zones. Four specimens had abundant vascularity and disorganised architecture of FNEs in the deeper zones of the antero-superior quadrant suggestive of a healed tear. Myofibroblasts were present in abundance in all the labral specimens and were distributed uniformly throughout all labral zones and depth.

Conclusions: The current study shows that the human acetabular labrum has abundant FNEs and NEOs. These are more abundant in the antero-superior and postero-superior zones. The labrum, by virtue of its neural innervation, can potentially mediate pain as well as proprioception of the hip joint, and be involved in neurosecretion that can influence connective tissue repair.

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Free nerve endings after immunohistochemistry stain for S-100 protein, x40.
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Figure 7: Free nerve endings after immunohistochemistry stain for S-100 protein, x40.

Mentions: While the FNEs and NEOs were identified in the superficial region of all the labral specimens, these were seen in the deeper layers in only 4 specimens of labrum and only in the antero-superior zones of these specimens. In all these 4 specimens, the FNEs were seen running across the substance of the labrum. Further, these FNEs were less well organized, and had a more radial and oblique arrangement. Interestingly, an abundant vascularity (not visible in any other layer or any other specimen) accompanied the FNEs in these 4 specimens (Figures 6 and7).


The innervation of the human acetabular labrum and hip joint: an anatomic study.

Alzaharani A, Bali K, Gudena R, Railton P, Ponjevic D, Matyas JR, Powell JN - BMC Musculoskelet Disord (2014)

Free nerve endings after immunohistochemistry stain for S-100 protein, x40.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927620&req=5

Figure 7: Free nerve endings after immunohistochemistry stain for S-100 protein, x40.
Mentions: While the FNEs and NEOs were identified in the superficial region of all the labral specimens, these were seen in the deeper layers in only 4 specimens of labrum and only in the antero-superior zones of these specimens. In all these 4 specimens, the FNEs were seen running across the substance of the labrum. Further, these FNEs were less well organized, and had a more radial and oblique arrangement. Interestingly, an abundant vascularity (not visible in any other layer or any other specimen) accompanied the FNEs in these 4 specimens (Figures 6 and7).

Bottom Line: FNEs and NEOs were more frequently seen in the antero-superior and postero-superior zones.Four specimens had abundant vascularity and disorganised architecture of FNEs in the deeper zones of the antero-superior quadrant suggestive of a healed tear.These are more abundant in the antero-superior and postero-superior zones.

View Article: PubMed Central - HTML - PubMed

Affiliation: Orthopedic Trauma & Lower Extremity Reconstruction, 3134 Hospital Drive N,W, Calgary, Alberta T2N 5A1, Canada. jnpowellemail@yahoo.ca.

ABSTRACT

Background: The aim of the current study was to evaluate the innervation of the acetabular labrum in the various zones and to understand its potential role in nociception and proprioception in hips with labral pathology.

Methods: A total of twenty hip labrums were tagged and excised intraoperatively from patients undergoing a total hip replacement. After preparation, the specimens were cut to a thickness of 10 μm and divided into four quadrants (zones) using a clock face pattern. Neurosensory structure distribution was then evaluated using Hematoxylin and Eosin (H and E), and immunoreactivity to S-100.

Results: All specimens had abundant free nerve endings (FNEs). These were seen predominantly superficially and on the chondral side of the labrum. In addition, predominantly three different types of nerve end organs (NEOs) were identified in all twenty specimens. FNEs and NEOs were more frequently seen in the antero-superior and postero-superior zones. Four specimens had abundant vascularity and disorganised architecture of FNEs in the deeper zones of the antero-superior quadrant suggestive of a healed tear. Myofibroblasts were present in abundance in all the labral specimens and were distributed uniformly throughout all labral zones and depth.

Conclusions: The current study shows that the human acetabular labrum has abundant FNEs and NEOs. These are more abundant in the antero-superior and postero-superior zones. The labrum, by virtue of its neural innervation, can potentially mediate pain as well as proprioception of the hip joint, and be involved in neurosecretion that can influence connective tissue repair.

Show MeSH
Related in: MedlinePlus