Limits...
Parameters associated with significant liver histological changes in patients with chronic hepatitis B.

Xiao L, Xian J, Li Y, Geng A, Yang X, Han L, Xu H - ISRN Gastroenterol (2014)

Bottom Line: This study aimed to evaluate factors associated with significant liver histological changes.Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001).Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

View Article: PubMed Central - PubMed

Affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.

ABSTRACT
This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg- patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg- (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

No MeSH data available.


Related in: MedlinePlus

The distribution of liver necroinflammation and fibrosis in patients with normal and abnormal ALT.
© Copyright Policy - open-access
Related In: Results  -  Collection


getmorefigures.php?uid=PMC3927580&req=5

fig3: The distribution of liver necroinflammation and fibrosis in patients with normal and abnormal ALT.

Mentions: A total of 31 patients (19.7%) had ALT levels within the normal range suggested by Prati et al. [25] (i.e., 30 U/L for men and 19 U/L for women) and 126 patients exceeded the Prati criteria. Nine of 31 (29%) patients with normal ALT had cirrhosis and 33 of 126 (26%) patients with abnormal ALT had cirrhosis. There was no significant difference in liver necroinflammation grades or fibrosis stages between patients with normal and abnormal ALT (P = 0.835 and P = 0.998, resp.) (Figure 3). Spearman's rank correlation showed that AST, WBC, and DNA were significantly correlated with advanced fibrosis in patients with normal ALT (P < 0.001, P = 0.041, and P = 0.012, resp.), while age, ALB, GLOB, PLT, and PT were significantly correlated with advanced fibrosis in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.).


Parameters associated with significant liver histological changes in patients with chronic hepatitis B.

Xiao L, Xian J, Li Y, Geng A, Yang X, Han L, Xu H - ISRN Gastroenterol (2014)

The distribution of liver necroinflammation and fibrosis in patients with normal and abnormal ALT.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3927580&req=5

fig3: The distribution of liver necroinflammation and fibrosis in patients with normal and abnormal ALT.
Mentions: A total of 31 patients (19.7%) had ALT levels within the normal range suggested by Prati et al. [25] (i.e., 30 U/L for men and 19 U/L for women) and 126 patients exceeded the Prati criteria. Nine of 31 (29%) patients with normal ALT had cirrhosis and 33 of 126 (26%) patients with abnormal ALT had cirrhosis. There was no significant difference in liver necroinflammation grades or fibrosis stages between patients with normal and abnormal ALT (P = 0.835 and P = 0.998, resp.) (Figure 3). Spearman's rank correlation showed that AST, WBC, and DNA were significantly correlated with advanced fibrosis in patients with normal ALT (P < 0.001, P = 0.041, and P = 0.012, resp.), while age, ALB, GLOB, PLT, and PT were significantly correlated with advanced fibrosis in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.).

Bottom Line: This study aimed to evaluate factors associated with significant liver histological changes.Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001).Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

View Article: PubMed Central - PubMed

Affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.

ABSTRACT
This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg- patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg- (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

No MeSH data available.


Related in: MedlinePlus