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Parameters associated with significant liver histological changes in patients with chronic hepatitis B.

Xiao L, Xian J, Li Y, Geng A, Yang X, Han L, Xu H - ISRN Gastroenterol (2014)

Bottom Line: This study aimed to evaluate factors associated with significant liver histological changes.Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001).Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

View Article: PubMed Central - PubMed

Affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.

ABSTRACT
This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg- patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg- (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

No MeSH data available.


Related in: MedlinePlus

Characteristic of HBV DNA and HBeAg status among different age groups in 157 patients with chronic HBV infection.
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fig2: Characteristic of HBV DNA and HBeAg status among different age groups in 157 patients with chronic HBV infection.

Mentions: The presence of HBeAg and hepatitis B viral load decreased with age: 28 (82%) and 28 (82%) had HBV DNA ≧ 5log copies/mL and HBeAg+, respectively, among the 34 patients aged ≦30. Seven (33%) and 3 (14%) had HBV DNA ≧ 5log copies/mL and HBeAg+, respectively, among the 21 patients aged >50 (Figure 2). The presence of HBeAg was associated with higher HBV DNA (P < 0.001).


Parameters associated with significant liver histological changes in patients with chronic hepatitis B.

Xiao L, Xian J, Li Y, Geng A, Yang X, Han L, Xu H - ISRN Gastroenterol (2014)

Characteristic of HBV DNA and HBeAg status among different age groups in 157 patients with chronic HBV infection.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3927580&req=5

fig2: Characteristic of HBV DNA and HBeAg status among different age groups in 157 patients with chronic HBV infection.
Mentions: The presence of HBeAg and hepatitis B viral load decreased with age: 28 (82%) and 28 (82%) had HBV DNA ≧ 5log copies/mL and HBeAg+, respectively, among the 34 patients aged ≦30. Seven (33%) and 3 (14%) had HBV DNA ≧ 5log copies/mL and HBeAg+, respectively, among the 21 patients aged >50 (Figure 2). The presence of HBeAg was associated with higher HBV DNA (P < 0.001).

Bottom Line: This study aimed to evaluate factors associated with significant liver histological changes.Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001).Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

View Article: PubMed Central - PubMed

Affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.

ABSTRACT
This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg- patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg- (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

No MeSH data available.


Related in: MedlinePlus