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Parameters associated with significant liver histological changes in patients with chronic hepatitis B.

Xiao L, Xian J, Li Y, Geng A, Yang X, Han L, Xu H - ISRN Gastroenterol (2014)

Bottom Line: This study aimed to evaluate factors associated with significant liver histological changes.Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001).Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

View Article: PubMed Central - PubMed

Affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.

ABSTRACT
This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg- patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg- (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

No MeSH data available.


Related in: MedlinePlus

Distribution of liver necroinflammation and liver fibrosis (based on Metair Score) among different age groups in 157 patients with chronic HBV infection.
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fig1: Distribution of liver necroinflammation and liver fibrosis (based on Metair Score) among different age groups in 157 patients with chronic HBV infection.

Mentions: A total of 34 patients were aged ≦30, 57 aged 30–40, 45 aged 40–50, and 21 aged >50. There was no significant difference in necroinflammation grades among different age groups (P = 0.120); however, increasing age was independently associated with significant fibrosis (P = 0.034) (Figure 1).


Parameters associated with significant liver histological changes in patients with chronic hepatitis B.

Xiao L, Xian J, Li Y, Geng A, Yang X, Han L, Xu H - ISRN Gastroenterol (2014)

Distribution of liver necroinflammation and liver fibrosis (based on Metair Score) among different age groups in 157 patients with chronic HBV infection.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC3927580&req=5

fig1: Distribution of liver necroinflammation and liver fibrosis (based on Metair Score) among different age groups in 157 patients with chronic HBV infection.
Mentions: A total of 34 patients were aged ≦30, 57 aged 30–40, 45 aged 40–50, and 21 aged >50. There was no significant difference in necroinflammation grades among different age groups (P = 0.120); however, increasing age was independently associated with significant fibrosis (P = 0.034) (Figure 1).

Bottom Line: This study aimed to evaluate factors associated with significant liver histological changes.Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001).Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

View Article: PubMed Central - PubMed

Affiliation: Department of Liver Diseases, Taizhou People's Hospital, Jiangsu 225300, China.

ABSTRACT
This study aimed to evaluate factors associated with significant liver histological changes. Liver biopsies from 157 CHB patients were retrospectively analyzed. Only ALB was significantly correlated with advanced liver necroinflammatory (P = 0.001). Age, ALB, GLOB, AST, PLT, and PT were independent predictors of significant fibrosis (P = 0.002, P < 0.001, P = 0.001, P = 0.048, P < 0.001, and P = 0.001, resp.). AST, WBC, and HBV DNA were significantly correlated with advanced fibrosis in normal ALT patients (P < 0.001, P = 0.041, and P = 0.012, resp.) and age, ALB, GLOB, PLT, and PT in patients with abnormal ALT (P = 0.003, P < 0.001, P = 0.004, P < 0.001, and P = 0.002, resp.). Age, AST, GGT, PLT, and PT were significantly associated with advanced fibrosis in HBeAg+ patients (P = 0.01, P = 0.016, P = 0.027, P = 0.016, and P = 0.009, resp.) and ALB, GLOB, WBC, PLT, and PT in HBeAg- patients (P < 0.001, P = 0.004, P = 0.005, P < 0.001, and P = 0.035, resp.). PLT was an excellent predictor for cirrhosis (P < 0.001 and AUROC = 0.805). ALT was not predictive of advanced fibrosis for patients with HBeAg+ or HBeAg- (P = 0.273 and P = 0.599, resp.). PLT was an excellent predictor for cirrhosis in CHB patients. Liver histopathology can be recommended for chronic HBV carriers of older age, with normal ALT, lower PLT, and lower ALB.

No MeSH data available.


Related in: MedlinePlus