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Early renal histological changes in alloxan-induced diabetic rats.

Pourghasem M, Nasiri E, Shafi H - Int J Mol Cell Med (2014)

Bottom Line: The average weight of kidneys increased when compared to non diabetic animals.Furthermore, the amount of blood flow in arteries of all diabetic kidneys has been enhanced.Diabetic nephropathy is a progressive disease and renal care design can help better prognosis achievement.

View Article: PubMed Central - PubMed

Affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.

ABSTRACT
Diabetes mellitus is a progressive disease. Most investigators have focused on glomerular changes in diabetic kidney and non-glomerular alterations have been less attended. The present study has been conducted to find early non-glomerular histological changes in diabetic renal tissue. Twenty male Wistar rats weighting 200-250 g were used for the diabetic group. Diabetes mellitus was induced by single injection of Alloxan. After 8 weeks, paraffin embedded blocks of kidneys were prepared for evaluating the histological changes due to diabetes. Histological study showed the deposit of eosinophilic materials in the intermediate substantial of medulla and thickening of renal arterial wall in the kidney of 70% of diabetic rats. The average weight of kidneys increased when compared to non diabetic animals. Furthermore, the amount of blood flow in arteries of all diabetic kidneys has been enhanced. The present study demonstrates some early renal histological changes in diabetes mellitus which were earlier compared to those reported previously. Diabetic nephropathy is a progressive disease and renal care design can help better prognosis achievement.

No MeSH data available.


Related in: MedlinePlus

Eosinophilic deposits in the diabetic kidney (Arrow). H&E × 400
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Figure 1: Eosinophilic deposits in the diabetic kidney (Arrow). H&E × 400

Mentions: Histological study showed a deposit of eosinophilic materials in the intermediate substantial of medulla in the kidney of 73% (11 rats) of diabetic animals (Figure 1). Vacuolar changes have been seen in the tubular cells of all diabetic kidneys. The average weight of kidneys increased compared to nondiabetic animals (P< 0.05, table 1).


Early renal histological changes in alloxan-induced diabetic rats.

Pourghasem M, Nasiri E, Shafi H - Int J Mol Cell Med (2014)

Eosinophilic deposits in the diabetic kidney (Arrow). H&E × 400
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927393&req=5

Figure 1: Eosinophilic deposits in the diabetic kidney (Arrow). H&E × 400
Mentions: Histological study showed a deposit of eosinophilic materials in the intermediate substantial of medulla in the kidney of 73% (11 rats) of diabetic animals (Figure 1). Vacuolar changes have been seen in the tubular cells of all diabetic kidneys. The average weight of kidneys increased compared to nondiabetic animals (P< 0.05, table 1).

Bottom Line: The average weight of kidneys increased when compared to non diabetic animals.Furthermore, the amount of blood flow in arteries of all diabetic kidneys has been enhanced.Diabetic nephropathy is a progressive disease and renal care design can help better prognosis achievement.

View Article: PubMed Central - PubMed

Affiliation: Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran.

ABSTRACT
Diabetes mellitus is a progressive disease. Most investigators have focused on glomerular changes in diabetic kidney and non-glomerular alterations have been less attended. The present study has been conducted to find early non-glomerular histological changes in diabetic renal tissue. Twenty male Wistar rats weighting 200-250 g were used for the diabetic group. Diabetes mellitus was induced by single injection of Alloxan. After 8 weeks, paraffin embedded blocks of kidneys were prepared for evaluating the histological changes due to diabetes. Histological study showed the deposit of eosinophilic materials in the intermediate substantial of medulla and thickening of renal arterial wall in the kidney of 70% of diabetic rats. The average weight of kidneys increased when compared to non diabetic animals. Furthermore, the amount of blood flow in arteries of all diabetic kidneys has been enhanced. The present study demonstrates some early renal histological changes in diabetes mellitus which were earlier compared to those reported previously. Diabetic nephropathy is a progressive disease and renal care design can help better prognosis achievement.

No MeSH data available.


Related in: MedlinePlus