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Comparative study of expression of smad3 in oral lichen planus and normal oral mucosa.

Nafarzadeh S, Ejtehadi S, Amini Shakib P, Fereidooni M, Bijani A - Int J Mol Cell Med (2013)

Bottom Line: Data were analyzed with paired T-test and Wilcoxon test by SPSS software.Expression of Smad3 in OLP samples and normal oral mucosa was different.This difference was statistically significant (P<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.

ABSTRACT
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa which is considered by the World Health Organization (WHO) as a premalignant condition. One step in malignant development is so called epithelial mesenchymal transition (EMT), a process whereby epithelial cells acquire mesenchymal characteristics. A factor known to induce EMT is the transforming growth factor-β (TGF-β), which uses the Smad proteins as mediators for its signaling. The aim of this study was to compare the expression of Smad 3 in Oral Lichen Planus and normal oral mucosa. This descriptive analytic study was performed on 30 patients with OLP (21 women and 9 men with mean age of 45.23± 2.44 years) and 20 normal oral mucosa (14 women and 6 men with mean age of 46.95± 2.21 years). The samples were studied by immunohistochemical staining. Data were analyzed with paired T-test and Wilcoxon test by SPSS software. Expression of Smad3 in OLP samples and normal oral mucosa was different. This difference was statistically significant (P<0.001). The apparently higher expression of Smad 3 in oral lichen planus compared to normal oral mucosa might help to discuss its higher potential for malignant transition.

No MeSH data available.


Related in: MedlinePlus

IHC staining of OLP demonstrates high expression (score 4) of SMAD3 (X400).
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Figure 2: IHC staining of OLP demonstrates high expression (score 4) of SMAD3 (X400).

Mentions: 22 (73.4%) samples of lichen planus were located in buccal mucosa, 1 (3.3%) in labial mucosa, 4 (13.3%) in tongue, 2 (6.7) in gingiva and 1 (3.3) in palate. In normal oral mucosa, the distribution of samples in the above locations was 16 (80%), 1 (5%), 2 (10%), 1 (5%) and 0 (0%) respectively. The results of immunohistochemical staining of Smad3 in both case and control groups are represented in table 1 and figures 1 and 2. Also, a significant difference of the expression of Smad3 was observed between normal oral mucosa and OLP (Table 2).


Comparative study of expression of smad3 in oral lichen planus and normal oral mucosa.

Nafarzadeh S, Ejtehadi S, Amini Shakib P, Fereidooni M, Bijani A - Int J Mol Cell Med (2013)

IHC staining of OLP demonstrates high expression (score 4) of SMAD3 (X400).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927385&req=5

Figure 2: IHC staining of OLP demonstrates high expression (score 4) of SMAD3 (X400).
Mentions: 22 (73.4%) samples of lichen planus were located in buccal mucosa, 1 (3.3%) in labial mucosa, 4 (13.3%) in tongue, 2 (6.7) in gingiva and 1 (3.3) in palate. In normal oral mucosa, the distribution of samples in the above locations was 16 (80%), 1 (5%), 2 (10%), 1 (5%) and 0 (0%) respectively. The results of immunohistochemical staining of Smad3 in both case and control groups are represented in table 1 and figures 1 and 2. Also, a significant difference of the expression of Smad3 was observed between normal oral mucosa and OLP (Table 2).

Bottom Line: Data were analyzed with paired T-test and Wilcoxon test by SPSS software.Expression of Smad3 in OLP samples and normal oral mucosa was different.This difference was statistically significant (P<0.001).

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran.

ABSTRACT
Oral lichen planus (OLP) is a chronic inflammatory disease of the oral mucosa which is considered by the World Health Organization (WHO) as a premalignant condition. One step in malignant development is so called epithelial mesenchymal transition (EMT), a process whereby epithelial cells acquire mesenchymal characteristics. A factor known to induce EMT is the transforming growth factor-β (TGF-β), which uses the Smad proteins as mediators for its signaling. The aim of this study was to compare the expression of Smad 3 in Oral Lichen Planus and normal oral mucosa. This descriptive analytic study was performed on 30 patients with OLP (21 women and 9 men with mean age of 45.23± 2.44 years) and 20 normal oral mucosa (14 women and 6 men with mean age of 46.95± 2.21 years). The samples were studied by immunohistochemical staining. Data were analyzed with paired T-test and Wilcoxon test by SPSS software. Expression of Smad3 in OLP samples and normal oral mucosa was different. This difference was statistically significant (P<0.001). The apparently higher expression of Smad 3 in oral lichen planus compared to normal oral mucosa might help to discuss its higher potential for malignant transition.

No MeSH data available.


Related in: MedlinePlus