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p53 and PCNA Expression in Keratocystic Odontogenic Tumors Compared with Selected Odontogenic Cysts.

Seyedmajidi M, Nafarzadeh S, Siadati S, Shafaee S, Bijani A, Keshmiri N - Int J Mol Cell Med (2013)

Bottom Line: The differences of p53 expression in basal and suprabasal layers as well as PCNA expression in the suprabasal layer were significant but there was no significant difference in PCNA expression in the basal layer of these lesions.Also, the high level of PCNA expression in the suprabasal layer of KCOT may justify its neoplastic nature and tendency to recurrence.KCOT and calcifying cystic odontogenic tumors did not show similar expression of studied biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Dental Materials Research Center, Dental Faculty, Babol University of Medical Sciences, Babol, Iran.

ABSTRACT
p53 and PCNA expression in keratocystic odontogenic tumors compared with selected odontogenic cysts Summary: The aim of this study was to evaluate p53 and PCNA expression in different odontogenic lesions regarding their different clinical behaviors. Slices prepared from 94 paraffin-embedded tissue blocks (25 radicular cysts (RC), 23 dentigerous cysts (DC), 23 keratocystic odontogenic tumors (KCOT) and 23 calcifying cystic odontogenic tumors (CCOT)) were stained with p53 and PCNA antibodies using immunohistochemistry procedure. The highest level of p53 expression was in the basal layer of RC, and the highest level of PCNA expression was in the suprabasal layer of KCOT. The differences of p53 expression in basal and suprabasal layers as well as PCNA expression in the suprabasal layer were significant but there was no significant difference in PCNA expression in the basal layer of these lesions. The expression of p53 in the basal layer of RC was higher than in other cysts. This may be due to intensive inflammatory infiltration. Also, the high level of PCNA expression in the suprabasal layer of KCOT may justify its neoplastic nature and tendency to recurrence. KCOT and calcifying cystic odontogenic tumors did not show similar expression of studied biomarkers.

No MeSH data available.


Related in: MedlinePlus

Immunohistochemical expression of p53 (A) and PCNA (B) in radicular cyst (400X).
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Figure 2: Immunohistochemical expression of p53 (A) and PCNA (B) in radicular cyst (400X).

Mentions: The percentage of p53 and PCNA stained cells in basal and suprabasal layers of radicular cyst, dentigerous cyst, KCOT and calcifying cystic odontogenic tumor (CCOT) are shown in Table 1. Figures 1-4 are the representatives of immuno-histochemical stainings.


p53 and PCNA Expression in Keratocystic Odontogenic Tumors Compared with Selected Odontogenic Cysts.

Seyedmajidi M, Nafarzadeh S, Siadati S, Shafaee S, Bijani A, Keshmiri N - Int J Mol Cell Med (2013)

Immunohistochemical expression of p53 (A) and PCNA (B) in radicular cyst (400X).
© Copyright Policy
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927379&req=5

Figure 2: Immunohistochemical expression of p53 (A) and PCNA (B) in radicular cyst (400X).
Mentions: The percentage of p53 and PCNA stained cells in basal and suprabasal layers of radicular cyst, dentigerous cyst, KCOT and calcifying cystic odontogenic tumor (CCOT) are shown in Table 1. Figures 1-4 are the representatives of immuno-histochemical stainings.

Bottom Line: The differences of p53 expression in basal and suprabasal layers as well as PCNA expression in the suprabasal layer were significant but there was no significant difference in PCNA expression in the basal layer of these lesions.Also, the high level of PCNA expression in the suprabasal layer of KCOT may justify its neoplastic nature and tendency to recurrence.KCOT and calcifying cystic odontogenic tumors did not show similar expression of studied biomarkers.

View Article: PubMed Central - PubMed

Affiliation: Dental Materials Research Center, Dental Faculty, Babol University of Medical Sciences, Babol, Iran.

ABSTRACT
p53 and PCNA expression in keratocystic odontogenic tumors compared with selected odontogenic cysts Summary: The aim of this study was to evaluate p53 and PCNA expression in different odontogenic lesions regarding their different clinical behaviors. Slices prepared from 94 paraffin-embedded tissue blocks (25 radicular cysts (RC), 23 dentigerous cysts (DC), 23 keratocystic odontogenic tumors (KCOT) and 23 calcifying cystic odontogenic tumors (CCOT)) were stained with p53 and PCNA antibodies using immunohistochemistry procedure. The highest level of p53 expression was in the basal layer of RC, and the highest level of PCNA expression was in the suprabasal layer of KCOT. The differences of p53 expression in basal and suprabasal layers as well as PCNA expression in the suprabasal layer were significant but there was no significant difference in PCNA expression in the basal layer of these lesions. The expression of p53 in the basal layer of RC was higher than in other cysts. This may be due to intensive inflammatory infiltration. Also, the high level of PCNA expression in the suprabasal layer of KCOT may justify its neoplastic nature and tendency to recurrence. KCOT and calcifying cystic odontogenic tumors did not show similar expression of studied biomarkers.

No MeSH data available.


Related in: MedlinePlus