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Cheilitis granulomatosa.

Kavya B, Gite M, Bhat M, Paremala K - J Oral Maxillofac Pathol (2013)

View Article: PubMed Central - PubMed

Affiliation: Departments of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka, India.

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History revealed that the patient had visited a dentist 1 month ago with a complaint of broken upper left lateral incisor that was extracted, since it was considered to be the possible source of trauma... There was no history of habits and medical history revealed that the patient was on antihistamines and prednisolone after which the lesion regressed for about a week and recurred again... There were no associated signs and symptoms... The underlying connective tissue showed organized non-caseating granulomas containing epithelioid cells, multinucleated giant cells of Langhans type with nine to thirteen nuclei arranged peripherally, surrounded by lymphocytes and plasma cells [Figures 3–5]... The stroma was edematous and contained intense, perivascular chronic inflammatory cell infiltrate... Multiple peripheral nerve twigs were found and were suggestive of peripheral neuropathy [Figure 6]... Symptoms include abdominal cramps, colicky pain, alternating constipation and diarrhea... Microscopically isolated, loose, poorly formed non-caseating granulomas are found deeply situated with occasional giant cells, scanty inflammatory cells and fibrosis... Microscopically, proliferative, non-caseating granulomas with epithelioid cells and multinucleated giant cells are seen... Often laminated basophilic calcifications known as Schaumann bodies, stellate inclusions known as asteroid bodies and Hamazaki-Wesenberg bodies are found... Microscopically, granulomas show circumscribed collections of epithelioid histiocytes, lymphocytes, multinucleated giant cells and central caseation necrosis... This was excluded as there were no other clinical symptoms or involvement of other sites.

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Stratified squamous epithelium exhibiting pseudoepitheliomatous hyperplasia with rich fibrocellular and fibrovascular connective tissue stroma. (H&E stain, ×40)
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Figure 2: Stratified squamous epithelium exhibiting pseudoepitheliomatous hyperplasia with rich fibrocellular and fibrovascular connective tissue stroma. (H&E stain, ×40)

Mentions: Microscopically, the section showed stratified squamous epithelium exhibiting pseudoepitheliomatous hyperplasia with areas of para and orthokeratinization [Figures 1 and 2]. The underlying connective tissue showed organized non-caseating granulomas containing epithelioid cells, multinucleated giant cells of Langhans type with nine to thirteen nuclei arranged peripherally, surrounded by lymphocytes and plasma cells [Figures 3–5]. These granulomas were surrounded by collagen fibers interspersed with fibroblasts and fibrocytes. The stroma was edematous and contained intense, perivascular chronic inflammatory cell infiltrate. Multiple peripheral nerve twigs were found and were suggestive of peripheral neuropathy [Figure 6].


Cheilitis granulomatosa.

Kavya B, Gite M, Bhat M, Paremala K - J Oral Maxillofac Pathol (2013)

Stratified squamous epithelium exhibiting pseudoepitheliomatous hyperplasia with rich fibrocellular and fibrovascular connective tissue stroma. (H&E stain, ×40)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927360&req=5

Figure 2: Stratified squamous epithelium exhibiting pseudoepitheliomatous hyperplasia with rich fibrocellular and fibrovascular connective tissue stroma. (H&E stain, ×40)
Mentions: Microscopically, the section showed stratified squamous epithelium exhibiting pseudoepitheliomatous hyperplasia with areas of para and orthokeratinization [Figures 1 and 2]. The underlying connective tissue showed organized non-caseating granulomas containing epithelioid cells, multinucleated giant cells of Langhans type with nine to thirteen nuclei arranged peripherally, surrounded by lymphocytes and plasma cells [Figures 3–5]. These granulomas were surrounded by collagen fibers interspersed with fibroblasts and fibrocytes. The stroma was edematous and contained intense, perivascular chronic inflammatory cell infiltrate. Multiple peripheral nerve twigs were found and were suggestive of peripheral neuropathy [Figure 6].

View Article: PubMed Central - PubMed

Affiliation: Departments of Oral and Maxillofacial Pathology, Krishnadevaraya College of Dental Sciences, Bangalore, Karnataka, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

History revealed that the patient had visited a dentist 1 month ago with a complaint of broken upper left lateral incisor that was extracted, since it was considered to be the possible source of trauma... There was no history of habits and medical history revealed that the patient was on antihistamines and prednisolone after which the lesion regressed for about a week and recurred again... There were no associated signs and symptoms... The underlying connective tissue showed organized non-caseating granulomas containing epithelioid cells, multinucleated giant cells of Langhans type with nine to thirteen nuclei arranged peripherally, surrounded by lymphocytes and plasma cells [Figures 3–5]... The stroma was edematous and contained intense, perivascular chronic inflammatory cell infiltrate... Multiple peripheral nerve twigs were found and were suggestive of peripheral neuropathy [Figure 6]... Symptoms include abdominal cramps, colicky pain, alternating constipation and diarrhea... Microscopically isolated, loose, poorly formed non-caseating granulomas are found deeply situated with occasional giant cells, scanty inflammatory cells and fibrosis... Microscopically, proliferative, non-caseating granulomas with epithelioid cells and multinucleated giant cells are seen... Often laminated basophilic calcifications known as Schaumann bodies, stellate inclusions known as asteroid bodies and Hamazaki-Wesenberg bodies are found... Microscopically, granulomas show circumscribed collections of epithelioid histiocytes, lymphocytes, multinucleated giant cells and central caseation necrosis... This was excluded as there were no other clinical symptoms or involvement of other sites.

No MeSH data available.


Related in: MedlinePlus