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Kimura's disease - An unusual presentation involving subcutaneous tissue, parotid gland and lymph node.

Sah P, Kamath A, Aramanadka C, Radhakrishnan R - J Oral Maxillofac Pathol (2013)

Bottom Line: Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration.Recent reports, however, have confirmed that the two are, in fact, separate entities.The clinical presentation was suggestive of Kimura's disease and microscopic examination following biopsy of the lesion allowed us to make a definitive diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

ABSTRACT
Kimura's disease is a rare chronic inflammatory condition of uncertain etiology which has an affinity for the Asian population. It primarily involves the head and neck region, presenting as deep subcutaneous masses and is often accompanied by regional lymphadenopathy and salivary gland involvement. Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration. For years, Kimura's disease was believed to be identical to or part of the same disease spectrum as angiolymphoid hyperplasia with eosinophilia (ALHE). Recent reports, however, have confirmed that the two are, in fact, separate entities. We report a case of Kimura's disease in a 22-year-old Indian male who presented with a subcutaneous mass, parotid enlargement and lymphadenopathy. The clinical presentation was suggestive of Kimura's disease and microscopic examination following biopsy of the lesion allowed us to make a definitive diagnosis.

No MeSH data available.


Related in: MedlinePlus

Radiographic image of contrast-enhanced coronal computed tomography scan showing enlarged left parotid gland and well-defined irregular soft tissue enhancing lesion in right buccal space and subcutaneous tissue
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Figure 2: Radiographic image of contrast-enhanced coronal computed tomography scan showing enlarged left parotid gland and well-defined irregular soft tissue enhancing lesion in right buccal space and subcutaneous tissue

Mentions: A computed tomography (CT) scan disclosed enlarged superficial and deep lobes of the left parotid gland, a well-defined lesion measuring 3.3 × 2.4 cm in the right buccal space and enlarged level IB, level III and level V lymph nodes [Figures 2 and 3]. Fine needle aspiration cytology (FNAC) from the left parotid swelling and lymph nodes, as well as from the right cheek gave the impression of chronic nonspecific lymphadenitis and myoepithelial sialadenitis. Based on the CT and FNAC findings, an incisional biopsy from the right cheek swelling and image guided biopsy from the left parotid lesion was advised.


Kimura's disease - An unusual presentation involving subcutaneous tissue, parotid gland and lymph node.

Sah P, Kamath A, Aramanadka C, Radhakrishnan R - J Oral Maxillofac Pathol (2013)

Radiographic image of contrast-enhanced coronal computed tomography scan showing enlarged left parotid gland and well-defined irregular soft tissue enhancing lesion in right buccal space and subcutaneous tissue
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927356&req=5

Figure 2: Radiographic image of contrast-enhanced coronal computed tomography scan showing enlarged left parotid gland and well-defined irregular soft tissue enhancing lesion in right buccal space and subcutaneous tissue
Mentions: A computed tomography (CT) scan disclosed enlarged superficial and deep lobes of the left parotid gland, a well-defined lesion measuring 3.3 × 2.4 cm in the right buccal space and enlarged level IB, level III and level V lymph nodes [Figures 2 and 3]. Fine needle aspiration cytology (FNAC) from the left parotid swelling and lymph nodes, as well as from the right cheek gave the impression of chronic nonspecific lymphadenitis and myoepithelial sialadenitis. Based on the CT and FNAC findings, an incisional biopsy from the right cheek swelling and image guided biopsy from the left parotid lesion was advised.

Bottom Line: Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration.Recent reports, however, have confirmed that the two are, in fact, separate entities.The clinical presentation was suggestive of Kimura's disease and microscopic examination following biopsy of the lesion allowed us to make a definitive diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

ABSTRACT
Kimura's disease is a rare chronic inflammatory condition of uncertain etiology which has an affinity for the Asian population. It primarily involves the head and neck region, presenting as deep subcutaneous masses and is often accompanied by regional lymphadenopathy and salivary gland involvement. Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration. For years, Kimura's disease was believed to be identical to or part of the same disease spectrum as angiolymphoid hyperplasia with eosinophilia (ALHE). Recent reports, however, have confirmed that the two are, in fact, separate entities. We report a case of Kimura's disease in a 22-year-old Indian male who presented with a subcutaneous mass, parotid enlargement and lymphadenopathy. The clinical presentation was suggestive of Kimura's disease and microscopic examination following biopsy of the lesion allowed us to make a definitive diagnosis.

No MeSH data available.


Related in: MedlinePlus