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Kimura's disease - An unusual presentation involving subcutaneous tissue, parotid gland and lymph node.

Sah P, Kamath A, Aramanadka C, Radhakrishnan R - J Oral Maxillofac Pathol (2013)

Bottom Line: Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration.Recent reports, however, have confirmed that the two are, in fact, separate entities.The clinical presentation was suggestive of Kimura's disease and microscopic examination following biopsy of the lesion allowed us to make a definitive diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

ABSTRACT
Kimura's disease is a rare chronic inflammatory condition of uncertain etiology which has an affinity for the Asian population. It primarily involves the head and neck region, presenting as deep subcutaneous masses and is often accompanied by regional lymphadenopathy and salivary gland involvement. Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration. For years, Kimura's disease was believed to be identical to or part of the same disease spectrum as angiolymphoid hyperplasia with eosinophilia (ALHE). Recent reports, however, have confirmed that the two are, in fact, separate entities. We report a case of Kimura's disease in a 22-year-old Indian male who presented with a subcutaneous mass, parotid enlargement and lymphadenopathy. The clinical presentation was suggestive of Kimura's disease and microscopic examination following biopsy of the lesion allowed us to make a definitive diagnosis.

No MeSH data available.


Related in: MedlinePlus

Clinical image of the patient showing bilateral swelling in the parotid region
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Figure 1: Clinical image of the patient showing bilateral swelling in the parotid region

Mentions: Physical examination revealed a 4 × 5 cm firm, nontender, subcutaneous mass in the region of the left parotid gland, overlying the left masseter muscle and extending from the zygomatic arch to the lower border of the mandible. The overlying skin was normal with respect to both color and temperature and facial nerve function was unaffected. The swelling on the right side had similar clinical characteristics but was 2 × 2.5 cm in size, located 3 cm from the corner of the mouth and well ahead of the anterior border of the ramus [Figure 1]. Bilateral submandibular and upper cervical lymph nodes were palpable. There was no axillary or inguinal lymphadenopathy and the liver and spleen were not enlarged.


Kimura's disease - An unusual presentation involving subcutaneous tissue, parotid gland and lymph node.

Sah P, Kamath A, Aramanadka C, Radhakrishnan R - J Oral Maxillofac Pathol (2013)

Clinical image of the patient showing bilateral swelling in the parotid region
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927356&req=5

Figure 1: Clinical image of the patient showing bilateral swelling in the parotid region
Mentions: Physical examination revealed a 4 × 5 cm firm, nontender, subcutaneous mass in the region of the left parotid gland, overlying the left masseter muscle and extending from the zygomatic arch to the lower border of the mandible. The overlying skin was normal with respect to both color and temperature and facial nerve function was unaffected. The swelling on the right side had similar clinical characteristics but was 2 × 2.5 cm in size, located 3 cm from the corner of the mouth and well ahead of the anterior border of the ramus [Figure 1]. Bilateral submandibular and upper cervical lymph nodes were palpable. There was no axillary or inguinal lymphadenopathy and the liver and spleen were not enlarged.

Bottom Line: Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration.Recent reports, however, have confirmed that the two are, in fact, separate entities.The clinical presentation was suggestive of Kimura's disease and microscopic examination following biopsy of the lesion allowed us to make a definitive diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Manipal College of Dental Sciences, Manipal, Karnataka, India.

ABSTRACT
Kimura's disease is a rare chronic inflammatory condition of uncertain etiology which has an affinity for the Asian population. It primarily involves the head and neck region, presenting as deep subcutaneous masses and is often accompanied by regional lymphadenopathy and salivary gland involvement. Peripheral blood eosinophilia and elevated serum immunoglobulin E (IgE) levels are characteristic features and the microscopic picture reveals lymphoid proliferation with eosinophilic infiltration. For years, Kimura's disease was believed to be identical to or part of the same disease spectrum as angiolymphoid hyperplasia with eosinophilia (ALHE). Recent reports, however, have confirmed that the two are, in fact, separate entities. We report a case of Kimura's disease in a 22-year-old Indian male who presented with a subcutaneous mass, parotid enlargement and lymphadenopathy. The clinical presentation was suggestive of Kimura's disease and microscopic examination following biopsy of the lesion allowed us to make a definitive diagnosis.

No MeSH data available.


Related in: MedlinePlus