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Granuloma with langhans giant cells: An overview.

Kumar SN, Prasad TS, Narayan PA, Muruganandhan J - J Oral Maxillofac Pathol (2013)

Bottom Line: Granuloma formation with multinucleated giant cells is seen in numerous diseases.A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages surrounded by a collar of lymphocytes and plasma cells.In this article, we present a case of granuloma formation with multiple Langhans giant cells along with an overview of the differential diagnoses, which include mycobacterium diseases, other bacterial infections, fungal infections, protozoal infections, and other granulomatous diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology and Oral and Maxillofacial Surgery, Sri Venkateswara Dental College and Hospital, Chennai, Tamil Nadu, India.

ABSTRACT
Granuloma formation with multinucleated giant cells is seen in numerous diseases. A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages surrounded by a collar of lymphocytes and plasma cells. In this article, we present a case of granuloma formation with multiple Langhans giant cells along with an overview of the differential diagnoses, which include mycobacterium diseases, other bacterial infections, fungal infections, protozoal infections, and other granulomatous diseases.

No MeSH data available.


Related in: MedlinePlus

Photomicrograph showing granuloma formation characterized by central epitheloid, foamy macrophages and presence of giant cells (H&E stain, ×40)
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Figure 2: Photomicrograph showing granuloma formation characterized by central epitheloid, foamy macrophages and presence of giant cells (H&E stain, ×40)

Mentions: Histologically, the lesional tissue was encapsulated and exhibited lymph node architecture with germinal centers [Figure 1]. The lesional tissue exhibited multiple granuloma formation and numerous giant cells. The granuloma was composed of central epitheloid and foamy macrophages bounded by lymphocytes and plasma cells [Figure 2]. Multinucleated giant cells were seen in different foci [Figure 3]. A few granulomas exhibited eosinophilic areas suggestive of central necrosis [Figure 4]. The giant cells were Langhans type displaying numerous nuclei arranged in horseshoe pattern and an eosinophilic cytoplasm [Figure 5a and b]. Some of the giant cells exhibited arrangement of the nuclei at both poles [Figure 6]. Nuclei were uniform and appeared normal and vesicular. The giant cells were not associated with hemorrhagic foci, which were fairly observed. The histopathology was suggestive of a chronic granulomatous disease.


Granuloma with langhans giant cells: An overview.

Kumar SN, Prasad TS, Narayan PA, Muruganandhan J - J Oral Maxillofac Pathol (2013)

Photomicrograph showing granuloma formation characterized by central epitheloid, foamy macrophages and presence of giant cells (H&E stain, ×40)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927347&req=5

Figure 2: Photomicrograph showing granuloma formation characterized by central epitheloid, foamy macrophages and presence of giant cells (H&E stain, ×40)
Mentions: Histologically, the lesional tissue was encapsulated and exhibited lymph node architecture with germinal centers [Figure 1]. The lesional tissue exhibited multiple granuloma formation and numerous giant cells. The granuloma was composed of central epitheloid and foamy macrophages bounded by lymphocytes and plasma cells [Figure 2]. Multinucleated giant cells were seen in different foci [Figure 3]. A few granulomas exhibited eosinophilic areas suggestive of central necrosis [Figure 4]. The giant cells were Langhans type displaying numerous nuclei arranged in horseshoe pattern and an eosinophilic cytoplasm [Figure 5a and b]. Some of the giant cells exhibited arrangement of the nuclei at both poles [Figure 6]. Nuclei were uniform and appeared normal and vesicular. The giant cells were not associated with hemorrhagic foci, which were fairly observed. The histopathology was suggestive of a chronic granulomatous disease.

Bottom Line: Granuloma formation with multinucleated giant cells is seen in numerous diseases.A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages surrounded by a collar of lymphocytes and plasma cells.In this article, we present a case of granuloma formation with multiple Langhans giant cells along with an overview of the differential diagnoses, which include mycobacterium diseases, other bacterial infections, fungal infections, protozoal infections, and other granulomatous diseases.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology and Oral and Maxillofacial Surgery, Sri Venkateswara Dental College and Hospital, Chennai, Tamil Nadu, India.

ABSTRACT
Granuloma formation with multinucleated giant cells is seen in numerous diseases. A granuloma is a focus of chronic inflammation consisting of a microscopic aggregation of macrophages surrounded by a collar of lymphocytes and plasma cells. In this article, we present a case of granuloma formation with multiple Langhans giant cells along with an overview of the differential diagnoses, which include mycobacterium diseases, other bacterial infections, fungal infections, protozoal infections, and other granulomatous diseases.

No MeSH data available.


Related in: MedlinePlus