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Primary oral myeloid sarcoma: Report of a case.

Kurdoğlu B, Oztemel A, Barış E, Sengüven B - J Oral Maxillofac Pathol (2013)

Bottom Line: These tumors are considered as specific lesions of acute myeloid leukemia.We present a case of a myeloid sarcoma of the upper vestibular gingiva in a 29-year-old woman who has no hematologic disease history.Multiple metastases were found in floor of the nasal cavity, left breast, and left lacrimal gland 12 months after primary diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.

ABSTRACT
Myeloid sarcoma is defined as a tumor mass of immature myeloid cells that may be observed in a variety of locations including bone, skin, lymph nodes and soft tissues. However, oral involvement of myeloid sarcoma is extremely rare. These tumors are considered as specific lesions of acute myeloid leukemia. We present a case of a myeloid sarcoma of the upper vestibular gingiva in a 29-year-old woman who has no hematologic disease history. Multiple metastases were found in floor of the nasal cavity, left breast, and left lacrimal gland 12 months after primary diagnosis.

No MeSH data available.


Related in: MedlinePlus

(a) Axial PET scan clearly depicts the tumor of the left mandible and floor of the nasal cavity. (b) Coronal PET scan view of the patient
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Figure 4: (a) Axial PET scan clearly depicts the tumor of the left mandible and floor of the nasal cavity. (b) Coronal PET scan view of the patient

Mentions: In PET/CT (Positron emission tomography/computed tomography) scans, tumor masses were apparent in mandible and on the floor of nasal cavity [Figure 4a]. The patient received combination of idarubicin and ARA-C (cytosine arabinoside) chemotherapy regimen at first treatment phase. Because of the enlargement of the masses and development of AML, in second chemotherapy session 3-5-7 (daunorubicin, etoposide, ARA-C) regimen was performed. Bone marrow transplantation was planned after the fourth chemotherapy session but during this hold on period other aggressive tumor masses were found in left lacrimal gland and left breast [Figure 4b]. Histopathological diagnoses of the new lesions were also MS. Unfortunately, the patient died waiting for the appropriate bone marrow transplant and after 15 months of first diagnosis of MS.


Primary oral myeloid sarcoma: Report of a case.

Kurdoğlu B, Oztemel A, Barış E, Sengüven B - J Oral Maxillofac Pathol (2013)

(a) Axial PET scan clearly depicts the tumor of the left mandible and floor of the nasal cavity. (b) Coronal PET scan view of the patient
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927345&req=5

Figure 4: (a) Axial PET scan clearly depicts the tumor of the left mandible and floor of the nasal cavity. (b) Coronal PET scan view of the patient
Mentions: In PET/CT (Positron emission tomography/computed tomography) scans, tumor masses were apparent in mandible and on the floor of nasal cavity [Figure 4a]. The patient received combination of idarubicin and ARA-C (cytosine arabinoside) chemotherapy regimen at first treatment phase. Because of the enlargement of the masses and development of AML, in second chemotherapy session 3-5-7 (daunorubicin, etoposide, ARA-C) regimen was performed. Bone marrow transplantation was planned after the fourth chemotherapy session but during this hold on period other aggressive tumor masses were found in left lacrimal gland and left breast [Figure 4b]. Histopathological diagnoses of the new lesions were also MS. Unfortunately, the patient died waiting for the appropriate bone marrow transplant and after 15 months of first diagnosis of MS.

Bottom Line: These tumors are considered as specific lesions of acute myeloid leukemia.We present a case of a myeloid sarcoma of the upper vestibular gingiva in a 29-year-old woman who has no hematologic disease history.Multiple metastases were found in floor of the nasal cavity, left breast, and left lacrimal gland 12 months after primary diagnosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Gazi University, Ankara, Turkey.

ABSTRACT
Myeloid sarcoma is defined as a tumor mass of immature myeloid cells that may be observed in a variety of locations including bone, skin, lymph nodes and soft tissues. However, oral involvement of myeloid sarcoma is extremely rare. These tumors are considered as specific lesions of acute myeloid leukemia. We present a case of a myeloid sarcoma of the upper vestibular gingiva in a 29-year-old woman who has no hematologic disease history. Multiple metastases were found in floor of the nasal cavity, left breast, and left lacrimal gland 12 months after primary diagnosis.

No MeSH data available.


Related in: MedlinePlus