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Plasma fibrinogen degradation products in betel nut chewers - with and without oral submucous fibrosis.

Kiran G, Muni Sekhar M, Hunasgi S, Ahmed SA, Suri C, Krishna A - J Oral Maxillofac Pathol (2013)

Bottom Line: All the betel nut chewers with OSMF showed the presence of plasma FDP.However, controls and subjects with habit, but without OSMF did not show FDP in the plasma.Spearman's rank correlation was used to find the association between the clinical and histological grades and it was not statistically significant (P = 0.910) and the correlation being 0.020.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, Hyderabad, India.

ABSTRACT

Context: Oral submucous fibrosis (OSMF) has a multifactorial etiology. Recent studies have shown that there is an increased level of fibrinogen degradation products (FDP) in plasma of OSMF patients suggesting its possible role in etiopathogenesis of OSMF.

Aims: To detect the presence of FDP in the plasma of betel nut chewers with and without OSMF and in normal subjects without any habits, to correlate these levels with respect to the clinical and histological grading of OSMF and whether it can be used as a nonsurgical diagnostic aid in detection of suspected OSMF cases.

Materials and methods: Study comprised of 35 cases of betel nut chewers with OSMF, 10 patients with betel nut chewing habit but having apparently normal oral mucosa, and 10 normal patients without any habits. The patients were evaluated for plasma FDP levels.

Results: All the betel nut chewers with OSMF showed the presence of plasma FDP. However, controls and subjects with habit, but without OSMF did not show FDP in the plasma. Spearman's rank correlation was used to find the association between the clinical and histological grades and it was not statistically significant (P = 0.910) and the correlation being 0.020.

Conclusion: Since only those patients with OSMF have showed the presence of FDP in plasma, we suggest that our test can be utilized as a nonsurgical diagnostic aid in suspected OSMF patients.

No MeSH data available.


Related in: MedlinePlus

Number and percentage of patients in different clinical grades of oral submucous fibrosis
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Figure 1: Number and percentage of patients in different clinical grades of oral submucous fibrosis

Mentions: Plasma FDP levels were detected (>200 ng/ml) in all Group A patients and the same was not detected in Group B and C patients. Since all the FDP values were same in Group A patients, no inferential statistical tests could be performed. We found that most of the Group A patients were in clinical grade II [Table 1, and Figure 1] and advanced histological grade [Table 2 and Figure 2]. We also found a trend that as clinical grade increased, more number of patients were in advanced histological grade [Table 3 and Figure 3]. Spearman's rank correlation was used to find the association between the clinical and histological grades and it was not statistically significant (P = 0.910) [Table 3 and Figure 3], the Spearman's rank correlation being 0.020. Statistical product and service solutions (SPSS) version 14.0 was used for computation of statistical tests.


Plasma fibrinogen degradation products in betel nut chewers - with and without oral submucous fibrosis.

Kiran G, Muni Sekhar M, Hunasgi S, Ahmed SA, Suri C, Krishna A - J Oral Maxillofac Pathol (2013)

Number and percentage of patients in different clinical grades of oral submucous fibrosis
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927329&req=5

Figure 1: Number and percentage of patients in different clinical grades of oral submucous fibrosis
Mentions: Plasma FDP levels were detected (>200 ng/ml) in all Group A patients and the same was not detected in Group B and C patients. Since all the FDP values were same in Group A patients, no inferential statistical tests could be performed. We found that most of the Group A patients were in clinical grade II [Table 1, and Figure 1] and advanced histological grade [Table 2 and Figure 2]. We also found a trend that as clinical grade increased, more number of patients were in advanced histological grade [Table 3 and Figure 3]. Spearman's rank correlation was used to find the association between the clinical and histological grades and it was not statistically significant (P = 0.910) [Table 3 and Figure 3], the Spearman's rank correlation being 0.020. Statistical product and service solutions (SPSS) version 14.0 was used for computation of statistical tests.

Bottom Line: All the betel nut chewers with OSMF showed the presence of plasma FDP.However, controls and subjects with habit, but without OSMF did not show FDP in the plasma.Spearman's rank correlation was used to find the association between the clinical and histological grades and it was not statistically significant (P = 0.910) and the correlation being 0.020.

View Article: PubMed Central - PubMed

Affiliation: Department of Oral and Maxillofacial Pathology, Government Dental College and Hospital, Hyderabad, India.

ABSTRACT

Context: Oral submucous fibrosis (OSMF) has a multifactorial etiology. Recent studies have shown that there is an increased level of fibrinogen degradation products (FDP) in plasma of OSMF patients suggesting its possible role in etiopathogenesis of OSMF.

Aims: To detect the presence of FDP in the plasma of betel nut chewers with and without OSMF and in normal subjects without any habits, to correlate these levels with respect to the clinical and histological grading of OSMF and whether it can be used as a nonsurgical diagnostic aid in detection of suspected OSMF cases.

Materials and methods: Study comprised of 35 cases of betel nut chewers with OSMF, 10 patients with betel nut chewing habit but having apparently normal oral mucosa, and 10 normal patients without any habits. The patients were evaluated for plasma FDP levels.

Results: All the betel nut chewers with OSMF showed the presence of plasma FDP. However, controls and subjects with habit, but without OSMF did not show FDP in the plasma. Spearman's rank correlation was used to find the association between the clinical and histological grades and it was not statistically significant (P = 0.910) and the correlation being 0.020.

Conclusion: Since only those patients with OSMF have showed the presence of FDP in plasma, we suggest that our test can be utilized as a nonsurgical diagnostic aid in suspected OSMF patients.

No MeSH data available.


Related in: MedlinePlus