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Is midazolam superior to triclofos and hydroxyzine as premedicant in children?

Chaudhary S, Jindal R, Girotra G, Salhotra R, Rautela RS, Sethi AK - J Anaesthesiol Clin Pharmacol (2014)

Bottom Line: Hydroxyzine was found to have lesser sedative effect as compared to both midazolam and triclofos.No major adverse effects were observed.Midazolam was found to be a better premedicant in terms of sedation, anxiolysis and safety.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.

ABSTRACT

Background: Search for an ideal premedicant drug for children is still on. A prospective, randomized trial was conducted to compare the efficacy of midazolam, triclofos and hydroxyzine as premedication in children undergoing lower abdominal surgeries.

Materials and methods: Sixty American Society of Anesthesiologists I or II patients 2-8 years of age, scheduled for elective lower abdominal surgery were included. The patients were randomly divided into three groups M, T and H of 20 children each who received midazolam 0.5 mg/kg, triclofos 75 mg/kg and hydroxyzine 0.5 mg/kg respectively, orally 60 min before surgery. The acceptability of drugs, level of sedation, anxiety during separation and on mask application was assessed.

Results: The acceptability of midazolam and hydroxyzine was better than triclofos. Hydroxyzine was found to have lesser sedative effect as compared to both midazolam and triclofos. No major adverse effects were observed.

Conclusion: Midazolam was found to be a better premedicant in terms of sedation, anxiolysis and safety.

No MeSH data available.


Related in: MedlinePlus

Compliance score (at time of drug administration) (1 = Good – readily takes medicine, 2 = Fair – accepts medicine with persuasion, 3 = Poor – unwilling to take medicine or spits it out, 4 = Refuses medicine)
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Figure 1: Compliance score (at time of drug administration) (1 = Good – readily takes medicine, 2 = Fair – accepts medicine with persuasion, 3 = Poor – unwilling to take medicine or spits it out, 4 = Refuses medicine)

Mentions: Greater percentage (95%) of children were compliant and accepted midazolam and hydroxyzine (Group M and H) as compared to triclofos (65%) [Figure 1]. However, there was statistically insignificant difference between the three groups (P = 0.16).


Is midazolam superior to triclofos and hydroxyzine as premedicant in children?

Chaudhary S, Jindal R, Girotra G, Salhotra R, Rautela RS, Sethi AK - J Anaesthesiol Clin Pharmacol (2014)

Compliance score (at time of drug administration) (1 = Good – readily takes medicine, 2 = Fair – accepts medicine with persuasion, 3 = Poor – unwilling to take medicine or spits it out, 4 = Refuses medicine)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927293&req=5

Figure 1: Compliance score (at time of drug administration) (1 = Good – readily takes medicine, 2 = Fair – accepts medicine with persuasion, 3 = Poor – unwilling to take medicine or spits it out, 4 = Refuses medicine)
Mentions: Greater percentage (95%) of children were compliant and accepted midazolam and hydroxyzine (Group M and H) as compared to triclofos (65%) [Figure 1]. However, there was statistically insignificant difference between the three groups (P = 0.16).

Bottom Line: Hydroxyzine was found to have lesser sedative effect as compared to both midazolam and triclofos.No major adverse effects were observed.Midazolam was found to be a better premedicant in terms of sedation, anxiolysis and safety.

View Article: PubMed Central - PubMed

Affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences & Guru Teg Bahadur Hospital, Dilshad Garden, New Delhi, India.

ABSTRACT

Background: Search for an ideal premedicant drug for children is still on. A prospective, randomized trial was conducted to compare the efficacy of midazolam, triclofos and hydroxyzine as premedication in children undergoing lower abdominal surgeries.

Materials and methods: Sixty American Society of Anesthesiologists I or II patients 2-8 years of age, scheduled for elective lower abdominal surgery were included. The patients were randomly divided into three groups M, T and H of 20 children each who received midazolam 0.5 mg/kg, triclofos 75 mg/kg and hydroxyzine 0.5 mg/kg respectively, orally 60 min before surgery. The acceptability of drugs, level of sedation, anxiety during separation and on mask application was assessed.

Results: The acceptability of midazolam and hydroxyzine was better than triclofos. Hydroxyzine was found to have lesser sedative effect as compared to both midazolam and triclofos. No major adverse effects were observed.

Conclusion: Midazolam was found to be a better premedicant in terms of sedation, anxiolysis and safety.

No MeSH data available.


Related in: MedlinePlus