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An effective pharmacological management of postburn hypertrophic scar pain.

Jain A, Agarwal A, Shamshery C - J Anaesthesiol Clin Pharmacol (2014)

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

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Sir, The pain associated with burn injuries is intense, unremitting, chronic and often debilitating... Second degree burns during the healing phase may be complicated by hypertrophic scars (HS)... Patient presented to us with severe burning pain in the HS... The pain was worse particularly in the summers and relatively better in the winters... Application of menthol talc decreased the symptoms for some time... Patient was kept on a fortnightly follow-up... Patient showed a significant improvement in symptoms within 5 days with progressive improvement in symptoms as the treatment proceeded... Neuropathic pain has always been a difficult to treat in comparison with the nociceptive pain... Diabetic neuropathy and neuropathic pain associated with it has been the basis of treatment of the neuropathic pain in other disorders... We propose that systemic medical therapy using standard anti-neuropathic medications may be effective in treating pain in HS... Pregabalin by binding to the α2δ subunit of the voltage-dependent calcium channel in the central nervous system decreases the release of neurotransmitters including glutamate, noradrenaline, substance P and calcitonin gene-related peptide... Although pharmacotherapy is essential for management of HS pain, the role of psychotherapy in the form of a variety of cognitive-behavioral therapies including distraction, imagery, biofeedback or hypnotic analgesia provided by trained staff cannot be underemphasized.

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Related in: MedlinePlus

Patient with extensive post burn hypertrophic scar
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Figure 1: Patient with extensive post burn hypertrophic scar

Mentions: Patient being discussed is a 25-year-old male patient who had suffered extensive burn injury due to explosion of a domestic liquefied petroleum gas cylinder [Figure 1]. The burn had occurred approximately 18 months back. The medical records of primary care revealed that the burn was 35% and grade 2. The recovery care had been performed at a local district hospital. The later part of recovery was complicated by development of HS with associated burning pain.


An effective pharmacological management of postburn hypertrophic scar pain.

Jain A, Agarwal A, Shamshery C - J Anaesthesiol Clin Pharmacol (2014)

Patient with extensive post burn hypertrophic scar
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927273&req=5

Figure 1: Patient with extensive post burn hypertrophic scar
Mentions: Patient being discussed is a 25-year-old male patient who had suffered extensive burn injury due to explosion of a domestic liquefied petroleum gas cylinder [Figure 1]. The burn had occurred approximately 18 months back. The medical records of primary care revealed that the burn was 35% and grade 2. The recovery care had been performed at a local district hospital. The later part of recovery was complicated by development of HS with associated burning pain.

View Article: PubMed Central - PubMed

Affiliation: Department of Anesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

AUTOMATICALLY GENERATED EXCERPT
Please rate it.

Sir, The pain associated with burn injuries is intense, unremitting, chronic and often debilitating... Second degree burns during the healing phase may be complicated by hypertrophic scars (HS)... Patient presented to us with severe burning pain in the HS... The pain was worse particularly in the summers and relatively better in the winters... Application of menthol talc decreased the symptoms for some time... Patient was kept on a fortnightly follow-up... Patient showed a significant improvement in symptoms within 5 days with progressive improvement in symptoms as the treatment proceeded... Neuropathic pain has always been a difficult to treat in comparison with the nociceptive pain... Diabetic neuropathy and neuropathic pain associated with it has been the basis of treatment of the neuropathic pain in other disorders... We propose that systemic medical therapy using standard anti-neuropathic medications may be effective in treating pain in HS... Pregabalin by binding to the α2δ subunit of the voltage-dependent calcium channel in the central nervous system decreases the release of neurotransmitters including glutamate, noradrenaline, substance P and calcitonin gene-related peptide... Although pharmacotherapy is essential for management of HS pain, the role of psychotherapy in the form of a variety of cognitive-behavioral therapies including distraction, imagery, biofeedback or hypnotic analgesia provided by trained staff cannot be underemphasized.

No MeSH data available.


Related in: MedlinePlus