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Overcoming recruitment barriers revealed high readiness to participate and low dropout rate among people with schizophrenia in a randomized controlled trial testing the effect of a Guided Self-Determination intervention.

Jørgensen R, Munk-Jørgensen P, Lysaker PH, Buck KD, Hansson L, Zoffmann V - BMC Psychiatry (2014)

Bottom Line: GSD is a shared decision-making and mutual problem-solving method using reflection sheets, which was developed in diabetes care and adjusted for this study and utilized by patients with schizophrenia.These challenges were overcome through: 1) extension of time, 2) expansion of the clinical recruitment area and 3) encouragement of professionals to invite patients to the study.Through overcoming these challenges, we identified a remarkably high patient-readiness to take part (101 of 120 asked accepted) and a low dropout rate (8%).

View Article: PubMed Central - HTML - PubMed

Affiliation: Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg University Hospital, Mølleparkvej 10, 9000 Aalborg, Denmark. rijo@rn.dk.

ABSTRACT

Background: Recruitment is one of the most serious challenges in performing randomized controlled trials. Often clinical trials with participants diagnosed with schizophrenia are terminated prematurely because of recruitment challenges resulting in a considerable waste of resources in the form of time, funding, and the participants' efforts. Dropout rates in schizophrenia trials are also high.Recruitment challenges are often due to patients not wanting to participate in research but can also be due to clinicians' concerns regarding individuals diagnosed with schizophrenia as participants in research. This paper reports how overcoming recruitment challenges not related to patients revealed high readiness to take part and low dropout rates in a one year long randomized controlled trial testing Guided Self-Determination (GSD) among outpatients with schizophrenia receiving treatment in Assertive Outreach Teams in the northern part of Denmark.

Methods: GSD is a shared decision-making and mutual problem-solving method using reflection sheets, which was developed in diabetes care and adjusted for this study and utilized by patients with schizophrenia. Descriptive data on strategies to overcome recruitment challenges were derived from notes and observations made during the randomized controlled trial testing of GSD in six outpatient teams.

Results: Three types of recruitment challenges not related to patients were identified and met during the trial: 1) organizational challenges, 2) challenges with finding eligible participants and 3) challenges with having professionals invite patients to participate. These challenges were overcome through: 1) extension of time, 2) expansion of the clinical recruitment area and 3) encouragement of professionals to invite patients to the study. Through overcoming these challenges, we identified a remarkably high patient-readiness to take part (101 of 120 asked accepted) and a low dropout rate (8%).

Conclusion: Distinction between recruitment challenges was important in discovering the readiness among patients with schizophrenia to take part in and complete a trial with the GSD-intervention.

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Overcoming recruitment challenges not related to patients revealed a high patient-readiness.
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Figure 1: Overcoming recruitment challenges not related to patients revealed a high patient-readiness.

Mentions: In the trial, barriers not related to patients were encountered. Three types of recruitment challenges not related to patients were identified: 1) organizational challenges, 2) challenges with finding eligible participants, and 3) challenges with having professionals invite patients. These challenges were overcome through: 1) extension of time, 2) expansion of the clinical recruitment area, and 3) encouragement of professionals to invite patients to the trial. Identifying and overcoming challenges not related to patients disclosed remarkably high patient-readiness to take part in the trial and a remarkably a low dropout rate (Figure 1: Overcoming recruitment challenges not related to patients revealed a high patient readiness).


Overcoming recruitment barriers revealed high readiness to participate and low dropout rate among people with schizophrenia in a randomized controlled trial testing the effect of a Guided Self-Determination intervention.

Jørgensen R, Munk-Jørgensen P, Lysaker PH, Buck KD, Hansson L, Zoffmann V - BMC Psychiatry (2014)

Overcoming recruitment challenges not related to patients revealed a high patient-readiness.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC3927263&req=5

Figure 1: Overcoming recruitment challenges not related to patients revealed a high patient-readiness.
Mentions: In the trial, barriers not related to patients were encountered. Three types of recruitment challenges not related to patients were identified: 1) organizational challenges, 2) challenges with finding eligible participants, and 3) challenges with having professionals invite patients. These challenges were overcome through: 1) extension of time, 2) expansion of the clinical recruitment area, and 3) encouragement of professionals to invite patients to the trial. Identifying and overcoming challenges not related to patients disclosed remarkably high patient-readiness to take part in the trial and a remarkably a low dropout rate (Figure 1: Overcoming recruitment challenges not related to patients revealed a high patient readiness).

Bottom Line: GSD is a shared decision-making and mutual problem-solving method using reflection sheets, which was developed in diabetes care and adjusted for this study and utilized by patients with schizophrenia.These challenges were overcome through: 1) extension of time, 2) expansion of the clinical recruitment area and 3) encouragement of professionals to invite patients to the study.Through overcoming these challenges, we identified a remarkably high patient-readiness to take part (101 of 120 asked accepted) and a low dropout rate (8%).

View Article: PubMed Central - HTML - PubMed

Affiliation: Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg University Hospital, Mølleparkvej 10, 9000 Aalborg, Denmark. rijo@rn.dk.

ABSTRACT

Background: Recruitment is one of the most serious challenges in performing randomized controlled trials. Often clinical trials with participants diagnosed with schizophrenia are terminated prematurely because of recruitment challenges resulting in a considerable waste of resources in the form of time, funding, and the participants' efforts. Dropout rates in schizophrenia trials are also high.Recruitment challenges are often due to patients not wanting to participate in research but can also be due to clinicians' concerns regarding individuals diagnosed with schizophrenia as participants in research. This paper reports how overcoming recruitment challenges not related to patients revealed high readiness to take part and low dropout rates in a one year long randomized controlled trial testing Guided Self-Determination (GSD) among outpatients with schizophrenia receiving treatment in Assertive Outreach Teams in the northern part of Denmark.

Methods: GSD is a shared decision-making and mutual problem-solving method using reflection sheets, which was developed in diabetes care and adjusted for this study and utilized by patients with schizophrenia. Descriptive data on strategies to overcome recruitment challenges were derived from notes and observations made during the randomized controlled trial testing of GSD in six outpatient teams.

Results: Three types of recruitment challenges not related to patients were identified and met during the trial: 1) organizational challenges, 2) challenges with finding eligible participants and 3) challenges with having professionals invite patients to participate. These challenges were overcome through: 1) extension of time, 2) expansion of the clinical recruitment area and 3) encouragement of professionals to invite patients to the study. Through overcoming these challenges, we identified a remarkably high patient-readiness to take part (101 of 120 asked accepted) and a low dropout rate (8%).

Conclusion: Distinction between recruitment challenges was important in discovering the readiness among patients with schizophrenia to take part in and complete a trial with the GSD-intervention.

Show MeSH
Related in: MedlinePlus